Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891781481> ?p ?o ?g. }
- W2891781481 abstract "People with neuropathic bladder (NB) secondary to spinal cord injury (SCI) are at risk for multiple genitourinary complications, the most frequent of which is urinary tract infection (UTI). Despite the high frequency with which UTI occurs, our understanding of the role of urinary microbes in health and disease is limited. In this paper, we present the first prospective case study integrating symptom reporting, urinalysis, urine cultivation, and 16S ribosomal ribonucleic acid (rRNA) sequencing of the urine microbiome.A 55-year-old male with NB secondary to SCI contributed 12 urine samples over an 8-month period during asymptomatic, symptomatic, and postantibiotic periods. All bacteria identified on culture were present on 16S rRNA sequencing, however, 16S rRNA sequencing revealed the presence of bacteria not isolated on culture. In particular, Burkholderia fungorum was present in three samples during both asymptomatic and symptomatic periods. White blood cells of ≥5-10/high power field and leukocyte esterase ≥2 on urinalysis was associated with the presence of symptoms.In this patient, there was a predominance of pathogenic bacteria and a lack of putative probiotic bacteria during both symptomatic and asymptomatic states. Urinalysis-defined inflammatory markers were present to a greater extent during symptomatic periods compared to the asymptomatic state, which may underscore a role for urinalysis or other inflammatory markers in differentiating asymptomatic bacteriuria from UTI in patients with NB. The finding of potentially pathogenic bacteria identified by sequencing but not cultivation, suggests a need for greater understanding of the relationships amongst bacterial species in the bacteriuric neuropathic bladder." @default.
- W2891781481 created "2018-09-27" @default.
- W2891781481 creator A5000357991 @default.
- W2891781481 creator A5005192036 @default.
- W2891781481 creator A5006849587 @default.
- W2891781481 creator A5014377525 @default.
- W2891781481 creator A5015086773 @default.
- W2891781481 creator A5015939038 @default.
- W2891781481 creator A5023048261 @default.
- W2891781481 creator A5052125958 @default.
- W2891781481 creator A5053453174 @default.
- W2891781481 date "2018-09-21" @default.
- W2891781481 modified "2023-10-12" @default.
- W2891781481 title "Identification of Burkholderia fungorum in the urine of an individual with spinal cord injury and augmentation cystoplasty using 16S sequencing: copathogen or innocent bystander?" @default.
- W2891781481 cites W140969232 @default.
- W2891781481 cites W1505136191 @default.
- W2891781481 cites W1974731862 @default.
- W2891781481 cites W1987882175 @default.
- W2891781481 cites W1989170406 @default.
- W2891781481 cites W1995615226 @default.
- W2891781481 cites W2004595656 @default.
- W2891781481 cites W2015458288 @default.
- W2891781481 cites W2026124863 @default.
- W2891781481 cites W2032255989 @default.
- W2891781481 cites W2033653181 @default.
- W2891781481 cites W2046249204 @default.
- W2891781481 cites W2096278211 @default.
- W2891781481 cites W2120088134 @default.
- W2891781481 cites W2125202832 @default.
- W2891781481 cites W2167327074 @default.
- W2891781481 cites W2169732340 @default.
- W2891781481 cites W2170360325 @default.
- W2891781481 cites W2326562314 @default.
- W2891781481 cites W2395463648 @default.
- W2891781481 cites W2498998695 @default.
- W2891781481 cites W2515833647 @default.
- W2891781481 cites W2606015934 @default.
- W2891781481 cites W2768502696 @default.
- W2891781481 cites W3174485034 @default.
- W2891781481 cites W4241303348 @default.
- W2891781481 doi "https://doi.org/10.1038/s41394-018-0115-2" @default.
- W2891781481 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6155001" @default.
- W2891781481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30275977" @default.
- W2891781481 hasPublicationYear "2018" @default.
- W2891781481 type Work @default.
- W2891781481 sameAs 2891781481 @default.
- W2891781481 citedByCount "9" @default.
- W2891781481 countsByYear W28917814812018 @default.
- W2891781481 countsByYear W28917814812019 @default.
- W2891781481 countsByYear W28917814812020 @default.
- W2891781481 countsByYear W28917814812021 @default.
- W2891781481 crossrefType "journal-article" @default.
- W2891781481 hasAuthorship W2891781481A5000357991 @default.
- W2891781481 hasAuthorship W2891781481A5005192036 @default.
- W2891781481 hasAuthorship W2891781481A5006849587 @default.
- W2891781481 hasAuthorship W2891781481A5014377525 @default.
- W2891781481 hasAuthorship W2891781481A5015086773 @default.
- W2891781481 hasAuthorship W2891781481A5015939038 @default.
- W2891781481 hasAuthorship W2891781481A5023048261 @default.
- W2891781481 hasAuthorship W2891781481A5052125958 @default.
- W2891781481 hasAuthorship W2891781481A5053453174 @default.
- W2891781481 hasBestOaLocation W28917814811 @default.
- W2891781481 hasConcept C118552586 @default.
- W2891781481 hasConcept C126322002 @default.
- W2891781481 hasConcept C203014093 @default.
- W2891781481 hasConcept C2777910003 @default.
- W2891781481 hasConcept C2778334475 @default.
- W2891781481 hasConcept C2779225474 @default.
- W2891781481 hasConcept C2780026642 @default.
- W2891781481 hasConcept C2780775167 @default.
- W2891781481 hasConcept C71924100 @default.
- W2891781481 hasConcept C77411442 @default.
- W2891781481 hasConcept C90924648 @default.
- W2891781481 hasConceptScore W2891781481C118552586 @default.
- W2891781481 hasConceptScore W2891781481C126322002 @default.
- W2891781481 hasConceptScore W2891781481C203014093 @default.
- W2891781481 hasConceptScore W2891781481C2777910003 @default.
- W2891781481 hasConceptScore W2891781481C2778334475 @default.
- W2891781481 hasConceptScore W2891781481C2779225474 @default.
- W2891781481 hasConceptScore W2891781481C2780026642 @default.
- W2891781481 hasConceptScore W2891781481C2780775167 @default.
- W2891781481 hasConceptScore W2891781481C71924100 @default.
- W2891781481 hasConceptScore W2891781481C77411442 @default.
- W2891781481 hasConceptScore W2891781481C90924648 @default.
- W2891781481 hasIssue "1" @default.
- W2891781481 hasLocation W28917814811 @default.
- W2891781481 hasLocation W28917814812 @default.
- W2891781481 hasLocation W28917814813 @default.
- W2891781481 hasLocation W28917814814 @default.
- W2891781481 hasOpenAccess W2891781481 @default.
- W2891781481 hasPrimaryLocation W28917814811 @default.
- W2891781481 hasRelatedWork W2092835313 @default.
- W2891781481 hasRelatedWork W2164156897 @default.
- W2891781481 hasRelatedWork W2319223091 @default.
- W2891781481 hasRelatedWork W2343608215 @default.
- W2891781481 hasRelatedWork W2399722855 @default.
- W2891781481 hasRelatedWork W2401977168 @default.
- W2891781481 hasRelatedWork W2971700887 @default.
- W2891781481 hasRelatedWork W3012038943 @default.
- W2891781481 hasRelatedWork W4205644260 @default.