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• W2891783321 endingPage "2393" @default.
• W2891783321 startingPage "2393" @default.
• W2891783321 abstract "Six new metabolites, actinofuranones D-I (compounds 1–6), were isolated together with three known compounds—JBIR-108 (7), E-975 (8), and E-492 (9)—from a fermentation broth of Streptomyces gramineus derived from the lichen Leptogium trichophorum. The structures of the new compounds 1–6 were established using comprehensive NMR spectroscopic data analysis, as well as UV, IR, and MS data. The anti-inflammatory activity of these isolated compounds were evaluated by examining their ability to inhibit nitric oxide (NO) production in LPS-stimulated RAW 264.7 macrophage cells. Compounds 4, 5, 8, and 9 attenuated the production of NO due to the suppression of the expression of nitric oxide synthase (iNOS) in LPS-induced RAW 264.7 cells. Moreover, 4, 5, 8, and 9 also inhibited LPS-induced release of proinflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α)." @default.
• W2891783321 created "2018-09-27" @default.
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• W2891783321 date "2018-09-18" @default.
• W2891783321 modified "2023-09-27" @default.
• W2891783321 title "Actinofuranones D-I from a Lichen-Associated Actinomycetes, Streptomyces gramineus, and Their Anti-Inflammatory Effects" @default.
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• W2891783321 doi "https://doi.org/10.3390/molecules23092393" @default.
• W2891783321 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6225470" @default.
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• W2891783321 hasPublicationYear "2018" @default.
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