Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891784070> ?p ?o ?g. }
- W2891784070 endingPage "189" @default.
- W2891784070 startingPage "179" @default.
- W2891784070 abstract "After recent outbreaks, Zika virus (ZIKV) was linked to severe neurological diseases including Guillain‐Barré syndrome in adults and microcephaly in newborns. The severities of pathological manifestations have been associated with different ZIKV strains. To better understand the tropism of ZIKV, we infected 10 human and four nonhuman cell lines (types) with two African (IbH30656 and MR766) and two Asian (PRVABC59 and H/FP/2013) ZIKV strains. Cell susceptibility to ZIKV infection was determined by examining viral titers, synthesis of viral proteins, and replication of positive and negative strands of viral genome. Among nonhuman cell lines, only Vero cells were efficiently infected by ZIKV. Among human cell lines, all were permissive to ZIKV infection. However, 293T and HeLa cells showed differential susceptibility towards African strains. In 293T cells, the NS1 protein was expressed at the high level by African strains but was almost not expressed by Asian strains though there was no obvious difference in viral genome replication, suggesting that the differential susceptibility might be controlled at the stage of viral protein translation. This study provides comprehensive results of the permissiveness of different cell types to both African and Asian ZIKV strains, which might help clarify their different pathogenesis." @default.
- W2891784070 created "2018-09-27" @default.
- W2891784070 creator A5007680995 @default.
- W2891784070 creator A5010896860 @default.
- W2891784070 creator A5040405172 @default.
- W2891784070 creator A5054150116 @default.
- W2891784070 creator A5067689954 @default.
- W2891784070 date "2018-10-09" @default.
- W2891784070 modified "2023-10-14" @default.
- W2891784070 title "Efficiencies and kinetics of infection in different cell types/lines by African and Asian strains of Zika virus" @default.
- W2891784070 cites W1545235721 @default.
- W2891784070 cites W1558143285 @default.
- W2891784070 cites W1857453373 @default.
- W2891784070 cites W1973619678 @default.
- W2891784070 cites W1975120587 @default.
- W2891784070 cites W1979001015 @default.
- W2891784070 cites W1981093311 @default.
- W2891784070 cites W2042530028 @default.
- W2891784070 cites W2053992388 @default.
- W2891784070 cites W2071467437 @default.
- W2891784070 cites W2077335256 @default.
- W2891784070 cites W2117649585 @default.
- W2891784070 cites W2122349387 @default.
- W2891784070 cites W2285713692 @default.
- W2891784070 cites W2288486409 @default.
- W2891784070 cites W2289704315 @default.
- W2891784070 cites W2294075455 @default.
- W2891784070 cites W2297318611 @default.
- W2891784070 cites W2300374904 @default.
- W2891784070 cites W2301346873 @default.
- W2891784070 cites W2316180691 @default.
- W2891784070 cites W2323221424 @default.
- W2891784070 cites W2327959547 @default.
- W2891784070 cites W2333018296 @default.
- W2891784070 cites W2337314156 @default.
- W2891784070 cites W2338618665 @default.
- W2891784070 cites W2339774778 @default.
- W2891784070 cites W2340156030 @default.
- W2891784070 cites W2343657527 @default.
- W2891784070 cites W2344122858 @default.
- W2891784070 cites W2345638947 @default.
- W2891784070 cites W2356757232 @default.
- W2891784070 cites W2360131028 @default.
- W2891784070 cites W2405496925 @default.
- W2891784070 cites W2473741889 @default.
- W2891784070 cites W2500723462 @default.
- W2891784070 cites W2508596867 @default.
- W2891784070 cites W2519646798 @default.
- W2891784070 cites W2520824982 @default.
- W2891784070 cites W2527686797 @default.
- W2891784070 cites W2559721763 @default.
- W2891784070 cites W2569913531 @default.
- W2891784070 cites W2578521629 @default.
- W2891784070 cites W2586343602 @default.
- W2891784070 cites W2588984569 @default.
- W2891784070 cites W2592541537 @default.
- W2891784070 cites W2597478663 @default.
- W2891784070 cites W2597508443 @default.
- W2891784070 cites W2597659832 @default.
- W2891784070 cites W2604643294 @default.
- W2891784070 cites W2742550402 @default.
- W2891784070 cites W2750045360 @default.
- W2891784070 cites W2768854167 @default.
- W2891784070 cites W2771181960 @default.
- W2891784070 cites W2777458426 @default.
- W2891784070 cites W2778774452 @default.
- W2891784070 cites W2781472954 @default.
- W2891784070 cites W3022354856 @default.
- W2891784070 cites W4205879768 @default.
- W2891784070 cites W4210694709 @default.
- W2891784070 cites W4210967474 @default.
- W2891784070 doi "https://doi.org/10.1002/jmv.25306" @default.
- W2891784070 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6294704" @default.
- W2891784070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30192399" @default.
- W2891784070 hasPublicationYear "2018" @default.
- W2891784070 type Work @default.
- W2891784070 sameAs 2891784070 @default.
- W2891784070 citedByCount "17" @default.
- W2891784070 countsByYear W28917840702019 @default.
- W2891784070 countsByYear W28917840702020 @default.
- W2891784070 countsByYear W28917840702021 @default.
- W2891784070 countsByYear W28917840702022 @default.
- W2891784070 countsByYear W28917840702023 @default.
- W2891784070 crossrefType "journal-article" @default.
- W2891784070 hasAuthorship W2891784070A5007680995 @default.
- W2891784070 hasAuthorship W2891784070A5010896860 @default.
- W2891784070 hasAuthorship W2891784070A5040405172 @default.
- W2891784070 hasAuthorship W2891784070A5054150116 @default.
- W2891784070 hasAuthorship W2891784070A5067689954 @default.
- W2891784070 hasBestOaLocation W28917840701 @default.
- W2891784070 hasConcept C104317684 @default.
- W2891784070 hasConcept C140704245 @default.
- W2891784070 hasConcept C141231307 @default.
- W2891784070 hasConcept C159047783 @default.
- W2891784070 hasConcept C174510640 @default.
- W2891784070 hasConcept C2522874641 @default.
- W2891784070 hasConcept C2776395126 @default.
- W2891784070 hasConcept C2777053367 @default.