Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891785668> ?p ?o ?g. }
- W2891785668 abstract "It is well known that pregnancy is under the constant influence of hormonal, metabolic and immunological factors and this may impact the oral microbiota towards pregnancy gingivitis. However, it is still not clear how the oral microbial dysbiosis can modulate oral diseases as oral microbiome during pregnancy is very poorly characterised. In addition, the recent revelation that placental microbiome is akin to oral microbiome further potentiates the importance of oral dysbiosis in adverse pregnancy outcomes. Hence, leveraging on the 16S rRNA gene sequencing technology, we present a snapshot of the variations in the oral microbial composition with the progression of pregnancy and in the postpartum period and its association with pregnancy gingivitis. Despite the stability of oral microbial diversity during pregnancy and postpartum period, we observed that the microbiome makes a pathogenic shift during pregnancy and reverts back to a healthy microbiome during the postpartum period. Co-occurrence network analysis provided a mechanistic explanation of the pathogenicity of the microbiome during pregnancy and predicted taxa at hubs of interaction. Targeting the taxa which form the ecological guilds in the underlying microbiome would help to modulate the microbial pathogenicity during pregnancy, thereby alleviating risk for oral diseases and adverse pregnancy outcomes. Our study has also uncovered the possibility of novel species in subgingival plaque and saliva as the key players in the causation of pregnancy gingivitis. The keystone species hold the potential to open up avenues for designing microbiome modulation strategies to improve host health during pregnancy." @default.
- W2891785668 created "2018-09-27" @default.
- W2891785668 creator A5007367790 @default.
- W2891785668 creator A5011331709 @default.
- W2891785668 creator A5029359087 @default.
- W2891785668 creator A5032519495 @default.
- W2891785668 creator A5072324020 @default.
- W2891785668 creator A5083567626 @default.
- W2891785668 creator A5084709436 @default.
- W2891785668 creator A5086679643 @default.
- W2891785668 date "2018-10-09" @default.
- W2891785668 modified "2023-10-13" @default.
- W2891785668 title "Keystone Species in Pregnancy Gingivitis: A Snapshot of Oral Microbiome During Pregnancy and Postpartum Period" @default.
- W2891785668 cites W1539534894 @default.
- W2891785668 cites W1594088758 @default.
- W2891785668 cites W1604633600 @default.
- W2891785668 cites W1909810669 @default.
- W2891785668 cites W1930591173 @default.
- W2891785668 cites W1966916702 @default.
- W2891785668 cites W1970418020 @default.
- W2891785668 cites W1981959283 @default.
- W2891785668 cites W1995875735 @default.
- W2891785668 cites W2007110604 @default.
- W2891785668 cites W2007843797 @default.
- W2891785668 cites W2021792184 @default.
- W2891785668 cites W2025019766 @default.
- W2891785668 cites W2037162110 @default.
- W2891785668 cites W2037234222 @default.
- W2891785668 cites W2040475339 @default.
- W2891785668 cites W2043248182 @default.
- W2891785668 cites W2046118138 @default.
- W2891785668 cites W2061252665 @default.
- W2891785668 cites W2064189633 @default.
- W2891785668 cites W2064522421 @default.
- W2891785668 cites W2088297260 @default.
- W2891785668 cites W2090711340 @default.
- W2891785668 cites W2091433858 @default.
- W2891785668 cites W2092238574 @default.
- W2891785668 cites W2095566926 @default.
- W2891785668 cites W2098988048 @default.
- W2891785668 cites W2103912979 @default.
- W2891785668 cites W2115699469 @default.
- W2891785668 cites W2119082754 @default.
- W2891785668 cites W2121748291 @default.
- W2891785668 cites W2131307186 @default.
- W2891785668 cites W2133264800 @default.
- W2891785668 cites W2136850043 @default.
- W2891785668 cites W2146554670 @default.
- W2891785668 cites W2159675211 @default.
- W2891785668 cites W2161632373 @default.
- W2891785668 cites W2166194480 @default.
- W2891785668 cites W2170196186 @default.
- W2891785668 cites W2172095976 @default.
- W2891785668 cites W2269529075 @default.
- W2891785668 cites W2400716300 @default.
- W2891785668 cites W2474696439 @default.
- W2891785668 cites W2522284601 @default.
- W2891785668 cites W2523457784 @default.
- W2891785668 cites W2573528553 @default.
- W2891785668 cites W2794046657 @default.
- W2891785668 cites W2794205287 @default.
- W2891785668 doi "https://doi.org/10.3389/fmicb.2018.02360" @default.
- W2891785668 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6189292" @default.
- W2891785668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30356676" @default.
- W2891785668 hasPublicationYear "2018" @default.
- W2891785668 type Work @default.
- W2891785668 sameAs 2891785668 @default.
- W2891785668 citedByCount "50" @default.
- W2891785668 countsByYear W28917856682019 @default.
- W2891785668 countsByYear W28917856682020 @default.
- W2891785668 countsByYear W28917856682021 @default.
- W2891785668 countsByYear W28917856682022 @default.
- W2891785668 countsByYear W28917856682023 @default.
- W2891785668 crossrefType "journal-article" @default.
- W2891785668 hasAuthorship W2891785668A5007367790 @default.
- W2891785668 hasAuthorship W2891785668A5011331709 @default.
- W2891785668 hasAuthorship W2891785668A5029359087 @default.
- W2891785668 hasAuthorship W2891785668A5032519495 @default.
- W2891785668 hasAuthorship W2891785668A5072324020 @default.
- W2891785668 hasAuthorship W2891785668A5083567626 @default.
- W2891785668 hasAuthorship W2891785668A5084709436 @default.
- W2891785668 hasAuthorship W2891785668A5086679643 @default.
- W2891785668 hasBestOaLocation W28917856681 @default.
- W2891785668 hasConcept C104317684 @default.
- W2891785668 hasConcept C143121216 @default.
- W2891785668 hasConcept C15151743 @default.
- W2891785668 hasConcept C199343813 @default.
- W2891785668 hasConcept C2777165150 @default.
- W2891785668 hasConcept C2779234561 @default.
- W2891785668 hasConcept C2780791200 @default.
- W2891785668 hasConcept C2910160754 @default.
- W2891785668 hasConcept C3018745865 @default.
- W2891785668 hasConcept C42407357 @default.
- W2891785668 hasConcept C54355233 @default.
- W2891785668 hasConcept C60644358 @default.
- W2891785668 hasConcept C71924100 @default.
- W2891785668 hasConcept C86803240 @default.
- W2891785668 hasConceptScore W2891785668C104317684 @default.
- W2891785668 hasConceptScore W2891785668C143121216 @default.
- W2891785668 hasConceptScore W2891785668C15151743 @default.