FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891785857> ?p ?o ?g. }

• W2891785857 abstract "e15155 Background: The SACURA trial is a phase III study to evaluate the superiority of 1-year adjuvant treatment with oral tegafur-uracil (UFT) to surgery alone for stage II colon cancer. Superiority of adjuvant treatment with UFT to surgery alone was not demonstrated (ASCO2016 abst#3617). In an additional translational study, we assessed microsatellite instability (MSI) status of cancer tissues and prospectively examined the association of MSI with prognosis in stage II colon cancer patients. Methods: Formalin-fixed, paraffin-embedded samples were prospectively collected from 1026 patients enrolled in the SACURA trial. MSI was evaluated using 5 markers; BAT25, BAT26, D2S123, D5S346, and D17S250. MSI-high (MSI-H) was defined as the presence of instability in more than 20% of the markers. Median follow-up time was 69.6 months. Results: MSI-H, MSI-low (MSI-L) and microsatellite-stable (MSS) was observed in 74 (7.2%), 24 (2.3%), and 928 (90.5%) samples, respectively. Patients with MSI-H was significantly frequent in female, right-sided colon cancers, > 5cm tumors, poor histological type, and elevated CEA. Relapse rate for MSI-H patients (4.1%) was significantly lower than that for MSI-L/MSS cancer (13.4%, p = 0.02). Relapse free survival (RFS) in MSI-H patients was significantly better than in MSI-L/MSS patients (hazard ratio: 0.40, 95%CI: 0.17-0.98, p = 0.045), as well as adjusted results by prognostic factors. The 5-year RFS rates in MSI-H and MSI-L/MSS patients were 92.9% and 84.1%, respectively. Although there was no statistical significance, the 5-year RFS rate in MSI-H patients was tended to be better than that in MSI-L/MSS patients in the surgery alone group (94.3% vs. 83.1%, p = 0.086) as well as in the UFT group (91.7% vs. 85.1%, p = 0.233). Conclusions: MSI was an independent prognostic factor in stage II colon cancers. By considering their favorable RFS, adjuvant chemotherapy for stage II colon cancer patients with MSI-H may be unnecessary. Clinical trial information: NCT00392899." @default.
• W2891785857 created "2018-09-27" @default.
• W2891785857 creator A5016215778 @default.
• W2891785857 creator A5017811687 @default.
• W2891785857 creator A5018138745 @default.
• W2891785857 creator A5020304167 @default.
• W2891785857 creator A5024247368 @default.
• W2891785857 creator A5025399736 @default.
• W2891785857 creator A5027999029 @default.
• W2891785857 creator A5030447469 @default.
• W2891785857 creator A5033008284 @default.
• W2891785857 creator A5053378428 @default.
• W2891785857 creator A5054771200 @default.
• W2891785857 creator A5056915467 @default.
• W2891785857 creator A5065433705 @default.
• W2891785857 creator A5082836616 @default.
• W2891785857 creator A5084276407 @default.
• W2891785857 date "2017-05-20" @default.
• W2891785857 modified "2023-10-02" @default.
• W2891785857 title "Prognostic impact of MSI in stage II colon cancers: An additional translational study of the SACURA trial." @default.
• W2891785857 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.e15155" @default.
• W2891785857 hasPublicationYear "2017" @default.
• W2891785857 type Work @default.
• W2891785857 sameAs 2891785857 @default.
• W2891785857 citedByCount "0" @default.
• W2891785857 crossrefType "journal-article" @default.
• W2891785857 hasAuthorship W2891785857A5016215778 @default.
• W2891785857 hasAuthorship W2891785857A5017811687 @default.
• W2891785857 hasAuthorship W2891785857A5018138745 @default.
• W2891785857 hasAuthorship W2891785857A5020304167 @default.
• W2891785857 hasAuthorship W2891785857A5024247368 @default.
• W2891785857 hasAuthorship W2891785857A5025399736 @default.
• W2891785857 hasAuthorship W2891785857A5027999029 @default.
• W2891785857 hasAuthorship W2891785857A5030447469 @default.
• W2891785857 hasAuthorship W2891785857A5033008284 @default.
• W2891785857 hasAuthorship W2891785857A5053378428 @default.
• W2891785857 hasAuthorship W2891785857A5054771200 @default.
• W2891785857 hasAuthorship W2891785857A5056915467 @default.
• W2891785857 hasAuthorship W2891785857A5065433705 @default.
• W2891785857 hasAuthorship W2891785857A5082836616 @default.
• W2891785857 hasAuthorship W2891785857A5084276407 @default.
• W2891785857 hasConcept C121608353 @default.
• W2891785857 hasConcept C126322002 @default.
• W2891785857 hasConcept C143998085 @default.
• W2891785857 hasConcept C146357865 @default.
• W2891785857 hasConcept C151730666 @default.
• W2891785857 hasConcept C526805850 @default.
• W2891785857 hasConcept C71924100 @default.
• W2891785857 hasConcept C86803240 @default.
• W2891785857 hasConceptScore W2891785857C121608353 @default.
• W2891785857 hasConceptScore W2891785857C126322002 @default.
• W2891785857 hasConceptScore W2891785857C143998085 @default.
• W2891785857 hasConceptScore W2891785857C146357865 @default.
• W2891785857 hasConceptScore W2891785857C151730666 @default.
• W2891785857 hasConceptScore W2891785857C526805850 @default.
• W2891785857 hasConceptScore W2891785857C71924100 @default.
• W2891785857 hasConceptScore W2891785857C86803240 @default.
• W2891785857 hasLocation W28917858571 @default.
• W2891785857 hasOpenAccess W2891785857 @default.
• W2891785857 hasPrimaryLocation W28917858571 @default.
• W2891785857 isParatext "false" @default.
• W2891785857 isRetracted "false" @default.
• W2891785857 magId "2891785857" @default.
• W2891785857 workType "article" @default.