FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891788986> ?p ?o ?g. }

• W2891788986 abstract "Abstract The efficacy of targeted MAPK signalling pathway inhibitors (MAPKi) in metastatic melanoma therapy is limited by the development of resistance mechanisms that results in disease relapse. This situation still requires treatment alternatives for melanoma patients with acquired resistance to targeted therapy. We found that melanoma cells, which developed resistance towards MAPKi show an enhanced susceptibility to platinum-based drugs, such as cisplatin and carboplatin. We found that this enhanced susceptibility inversely correlates with the expression level of the p53 family member TAp73. We show that the lower expression of the TAp73 isoform in MAPKi-resistant melanoma cells enhances accumulation of DNA double-strand breaks upon cisplatin and carboplatin treatment by reducing the efficiency of nucleotide excision repair. These data suggest that a subgroup of melanoma patients with acquired resistance to MAPKi treatment and low TAp73 expression can benefit from chemotherapy with platinum-based drugs as a second-line therapy." @default.
• W2891788986 created "2018-09-27" @default.
• W2891788986 creator A5001548963 @default.
• W2891788986 creator A5004823373 @default.
• W2891788986 creator A5011429266 @default.
• W2891788986 creator A5027968676 @default.
• W2891788986 creator A5029443722 @default.
• W2891788986 creator A5053679261 @default.
• W2891788986 creator A5080628640 @default.
• W2891788986 creator A5083713436 @default.
• W2891788986 date "2018-09-11" @default.
• W2891788986 modified "2023-10-14" @default.
• W2891788986 title "Melanoma cells resistant towards MAPK inhibitors exhibit reduced TAp73 expression mediating enhanced sensitivity to platinum-based drugs" @default.
• W2891788986 cites W1482719134 @default.
• W2891788986 cites W1620980074 @default.
• W2891788986 cites W1800754688 @default.
• W2891788986 cites W1834835434 @default.
• W2891788986 cites W1939117974 @default.
• W2891788986 cites W1956067208 @default.
• W2891788986 cites W1965480120 @default.
• W2891788986 cites W1976776826 @default.
• W2891788986 cites W1984247920 @default.
• W2891788986 cites W1984960790 @default.
• W2891788986 cites W1986076152 @default.
• W2891788986 cites W1997452749 @default.
• W2891788986 cites W1997909925 @default.
• W2891788986 cites W2004479656 @default.
• W2891788986 cites W2007106796 @default.
• W2891788986 cites W2014966556 @default.
• W2891788986 cites W2019607817 @default.
• W2891788986 cites W2024828955 @default.
• W2891788986 cites W2026203131 @default.
• W2891788986 cites W2032211985 @default.
• W2891788986 cites W2032822844 @default.
• W2891788986 cites W2040622041 @default.
• W2891788986 cites W2041052361 @default.
• W2891788986 cites W2051808614 @default.
• W2891788986 cites W2060371289 @default.
• W2891788986 cites W2062181317 @default.
• W2891788986 cites W2066717393 @default.
• W2891788986 cites W2068346944 @default.
• W2891788986 cites W2068445514 @default.
• W2891788986 cites W2068944057 @default.
• W2891788986 cites W2074416370 @default.
• W2891788986 cites W2100610935 @default.
• W2891788986 cites W2103557568 @default.
• W2891788986 cites W2105660237 @default.
• W2891788986 cites W2106355114 @default.
• W2891788986 cites W2112396116 @default.
• W2891788986 cites W2118118849 @default.
• W2891788986 cites W2121186077 @default.
• W2891788986 cites W2139248078 @default.
• W2891788986 cites W2152315800 @default.
• W2891788986 cites W2155104279 @default.
• W2891788986 cites W2155594628 @default.
• W2891788986 cites W2155988062 @default.
• W2891788986 cites W2168143310 @default.
• W2891788986 cites W2328243002 @default.
• W2891788986 cites W2344214299 @default.
• W2891788986 cites W2585122966 @default.
• W2891788986 doi "https://doi.org/10.1038/s41419-018-0952-8" @default.
• W2891788986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6133963" @default.
• W2891788986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30206212" @default.
• W2891788986 hasPublicationYear "2018" @default.
• W2891788986 type Work @default.
• W2891788986 sameAs 2891788986 @default.
• W2891788986 citedByCount "13" @default.
• W2891788986 countsByYear W28917889862019 @default.
• W2891788986 countsByYear W28917889862020 @default.
• W2891788986 countsByYear W28917889862021 @default.
• W2891788986 countsByYear W28917889862022 @default.
• W2891788986 countsByYear W28917889862023 @default.
• W2891788986 crossrefType "journal-article" @default.
• W2891788986 hasAuthorship W2891788986A5001548963 @default.
• W2891788986 hasAuthorship W2891788986A5004823373 @default.
• W2891788986 hasAuthorship W2891788986A5011429266 @default.
• W2891788986 hasAuthorship W2891788986A5027968676 @default.
• W2891788986 hasAuthorship W2891788986A5029443722 @default.
• W2891788986 hasAuthorship W2891788986A5053679261 @default.
• W2891788986 hasAuthorship W2891788986A5080628640 @default.
• W2891788986 hasAuthorship W2891788986A5083713436 @default.
• W2891788986 hasBestOaLocation W28917889861 @default.
• W2891788986 hasConcept C104317684 @default.
• W2891788986 hasConcept C104451858 @default.
• W2891788986 hasConcept C143425029 @default.
• W2891788986 hasConcept C2776694085 @default.
• W2891788986 hasConcept C2777658100 @default.
• W2891788986 hasConcept C2778239845 @default.
• W2891788986 hasConcept C2781451048 @default.
• W2891788986 hasConcept C502942594 @default.
• W2891788986 hasConcept C53345823 @default.
• W2891788986 hasConcept C54355233 @default.
• W2891788986 hasConcept C552990157 @default.
• W2891788986 hasConcept C57074206 @default.
• W2891788986 hasConcept C62478195 @default.
• W2891788986 hasConcept C86803240 @default.
• W2891788986 hasConceptScore W2891788986C104317684 @default.
• W2891788986 hasConceptScore W2891788986C104451858 @default.
• W2891788986 hasConceptScore W2891788986C143425029 @default.
• W2891788986 hasConceptScore W2891788986C2776694085 @default.

• next