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• W2891789425 endingPage "231" @default.
• W2891789425 startingPage "231" @default.
• W2891789425 abstract "The role of prophylactic antibiotics for laparoscopic cholecystectomy in low-risk patients is still unclear. This study aimed to verify the conclusion of previous meta-analyses concerning the effectiveness of antibiotic prophylaxis for elective laparoscopic cholecystectomy in low-risk patients.Comprehensive literature searches were performed on electric databases and manual searches. Randomized controlled trials (RCTs), prospective studies, and retrospective studies comparing antibiotic prophylaxis to placebo or no antibiotics in low-risk elective laparoscopic cholecystectomy were included.This study included 28 RCTs, three prospective studies, and three retrospective studies. In RCTs, prophylactic antibiotics did not prevent deep surgical site infections (SSI) (RR 1.10, 95% confidence interval [CI] [0.45-2.69], p=0.84) but reduced SSI (RR 0.70, 95% CI [0.53-0.94], p=0.02), and superficial SSI (RR 0.58, 95% CI [0.42-0.82], p=0.01). Prospective studies showed prophylactic antibiotics did not reduce superficial SSI (RR 0.35, 95% CI [0.01-8.40], p=0.52) but reduced SSI (RR 0.12, 95% CI [0.04-0.35], p=0.0001). In retrospective studies, antibiotic prophylaxis did not reduce SSI (RR 1.59, 95% CI [0.30-8.32], p=0.58). The pooled data (12121 patients) including RCTs and prospective and retrospective studies showed that prophylactic antibiotics were not effective in preventing deep SSI (RR 1.01 95% CI [0.46-2.21], p=0.98) but effective in reducing SSI (RR 0.67, 95% CI [0.51-0.88], p=0.003) and superficial SSI (RR 0.61, 95% CI [0.45-0.83], p=0.002).The use of prophylactic antibiotics is effective for reducing the incidence of SSI and superficial SSI but is not effective for preventing deep SSI in low-risk patients who underwent elective laparoscopic cholecystectomy." @default.
• W2891789425 created "2018-09-27" @default.
• W2891789425 creator A5000869364 @default.
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• W2891789425 creator A5033727868 @default.
• W2891789425 date "2018-01-01" @default.
• W2891789425 modified "2023-10-13" @default.
• W2891789425 title "Role of prophylactic antibiotics in elective laparoscopic cholecystectomy: A systematic review and meta-analysis" @default.
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• W2891789425 doi "https://doi.org/10.14701/ahbps.2018.22.3.231" @default.
• W2891789425 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6125276" @default.
• W2891789425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30215045" @default.
• W2891789425 hasPublicationYear "2018" @default.
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