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- W2891790429 abstract "Abstract Regulation of gene expression is thought to play a major role in adaptation but the relative importance of cis - and trans -regulatory mechanisms in the early stages of adaptive divergence is unclear. Using RNAseq of threespine stickleback fish gill tissue from four independent marine-freshwater ecotype pairs and their F1 hybrids, we show that cis -acting (allele-specific) regulation consistently predominates gene expression divergence. Genes showing parallel marine-freshwater expression divergence are found near to adaptive genomic regions, show signatures of natural selection around their transcription start sites and are enriched for cis- regulatory control. For genes with parallel increased expression among freshwater fish, the quantitative degree of cis- and trans- regulation is also highly correlated across populations, suggesting a shared genetic basis. Compared to other forms of regulation, cis- regulation tends to show greater additivity and stability across different genetic and environmental contexts, making it a fertile substrate for the early stages of adaptive evolution." @default.
- W2891790429 created "2018-09-27" @default.
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- W2891790429 date "2018-09-10" @default.
- W2891790429 modified "2023-10-14" @default.
- W2891790429 title "Predominance of cis-regulatory changes in parallel expression divergence of sticklebacks" @default.
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- W2891790429 doi "https://doi.org/10.1101/412932" @default.
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