FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891791005> ?p ?o ?g. }

• W2891791005 endingPage "846" @default.
• W2891791005 startingPage "835" @default.
• W2891791005 abstract "More than 80,000 chemicals are in commercial use worldwide. Hepatic metabolism to toxic intermediates is often a key mechanism leading to tissue damage and organ dysfunction. Effective treatment requires prompt detection of hepatotoxicity, ideally with rapid, minimally invasive diagnostic assays. In this study, archetypal histologic features of chemically induced hepatic injury were compared with clinical chemistries (including liver enzymes) and serum concentrations of microRNA-122 (miR-122, the processed form miR-122-5p), a biomarker of liver injury. The hepatotoxicants 4,4’-methylenedianiline (4,4’-MDA), allyl alcohol (AA), or carbon tetrachloride (CCl 4 ) were orally administered to male Sprague-Dawley rats for 1, 5, 14, or 28 days to induce liver damage. Formalin-fixed, paraffin-embedded liver sections were evaluated histologically for inflammation, fibrosis, necrosis, and lipid accumulation. Liver enzymes were measured in serum, and serum miR-122 concentrations were assessed by quantitative polymerase chain reaction (qPCR). Histologic features of hepatic injury dose-dependently increased in both severity and frequency. Increases in liver enzymes and bilirubin were more pronounced in response to AA or 4,4’-MDA than to CCl 4 at early time points. Elevated serum miR-122 levels in animals administered CCl 4 , AA, or 4,4’-MDA were more strongly associated with degree of hepatic histopathology than with dosage. Given this sensitive expression pattern postexposure, liver-specific miR-122 may improve the diagnostic accuracy of early hepatic injury." @default.
• W2891791005 created "2018-09-27" @default.
• W2891791005 creator A5008040383 @default.
• W2891791005 creator A5008112244 @default.
• W2891791005 creator A5020076324 @default.
• W2891791005 creator A5029935997 @default.
• W2891791005 creator A5031124868 @default.
• W2891791005 creator A5038284765 @default.
• W2891791005 creator A5047493245 @default.
• W2891791005 creator A5080762719 @default.
• W2891791005 creator A5082106898 @default.
• W2891791005 creator A5090989884 @default.
• W2891791005 date "2018-09-11" @default.
• W2891791005 modified "2023-09-27" @default.
• W2891791005 title "Utility of Serum miR-122, Liver Enzymes, and Hepatic Histopathology in Response to Hepatotoxicants in Sprague-Dawley Rats" @default.
• W2891791005 cites W1463602523 @default.
• W2891791005 cites W1983973523 @default.
• W2891791005 cites W1992819762 @default.
• W2891791005 cites W1995932555 @default.
• W2891791005 cites W1996202645 @default.
• W2891791005 cites W2025501549 @default.
• W2891791005 cites W2026697437 @default.
• W2891791005 cites W2045376844 @default.
• W2891791005 cites W2051994750 @default.
• W2891791005 cites W2062811432 @default.
• W2891791005 cites W2101225650 @default.
• W2891791005 cites W2111848990 @default.
• W2891791005 cites W2127153014 @default.
• W2891791005 cites W2137638861 @default.
• W2891791005 cites W2142741880 @default.
• W2891791005 cites W2146653867 @default.
• W2891791005 cites W2179842400 @default.
• W2891791005 cites W2188699551 @default.
• W2891791005 cites W2255745755 @default.
• W2891791005 cites W2730938950 @default.
• W2891791005 cites W2792566653 @default.
• W2891791005 cites W4255712601 @default.
• W2891791005 doi "https://doi.org/10.1177/0192623318795435" @default.
• W2891791005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30205766" @default.
• W2891791005 hasPublicationYear "2018" @default.
• W2891791005 type Work @default.
• W2891791005 sameAs 2891791005 @default.
• W2891791005 citedByCount "6" @default.
• W2891791005 countsByYear W28917910052019 @default.
• W2891791005 countsByYear W28917910052020 @default.
• W2891791005 countsByYear W28917910052021 @default.
• W2891791005 countsByYear W28917910052022 @default.
• W2891791005 countsByYear W28917910052023 @default.
• W2891791005 crossrefType "journal-article" @default.
• W2891791005 hasAuthorship W2891791005A5008040383 @default.
• W2891791005 hasAuthorship W2891791005A5008112244 @default.
• W2891791005 hasAuthorship W2891791005A5020076324 @default.
• W2891791005 hasAuthorship W2891791005A5029935997 @default.
• W2891791005 hasAuthorship W2891791005A5031124868 @default.
• W2891791005 hasAuthorship W2891791005A5038284765 @default.
• W2891791005 hasAuthorship W2891791005A5047493245 @default.
• W2891791005 hasAuthorship W2891791005A5080762719 @default.
• W2891791005 hasAuthorship W2891791005A5082106898 @default.
• W2891791005 hasAuthorship W2891791005A5090989884 @default.
• W2891791005 hasConcept C126322002 @default.
• W2891791005 hasConcept C142724271 @default.
• W2891791005 hasConcept C178790620 @default.
• W2891791005 hasConcept C185592680 @default.
• W2891791005 hasConcept C203014093 @default.
• W2891791005 hasConcept C2522874641 @default.
• W2891791005 hasConcept C2776408679 @default.
• W2891791005 hasConcept C2776637226 @default.
• W2891791005 hasConcept C2776914184 @default.
• W2891791005 hasConcept C2777214474 @default.
• W2891791005 hasConcept C2777359374 @default.
• W2891791005 hasConcept C2780559512 @default.
• W2891791005 hasConcept C2993667909 @default.
• W2891791005 hasConcept C53673613 @default.
• W2891791005 hasConcept C544855455 @default.
• W2891791005 hasConcept C71924100 @default.
• W2891791005 hasConcept C98274493 @default.
• W2891791005 hasConceptScore W2891791005C126322002 @default.
• W2891791005 hasConceptScore W2891791005C142724271 @default.
• W2891791005 hasConceptScore W2891791005C178790620 @default.
• W2891791005 hasConceptScore W2891791005C185592680 @default.
• W2891791005 hasConceptScore W2891791005C203014093 @default.
• W2891791005 hasConceptScore W2891791005C2522874641 @default.
• W2891791005 hasConceptScore W2891791005C2776408679 @default.
• W2891791005 hasConceptScore W2891791005C2776637226 @default.
• W2891791005 hasConceptScore W2891791005C2776914184 @default.
• W2891791005 hasConceptScore W2891791005C2777214474 @default.
• W2891791005 hasConceptScore W2891791005C2777359374 @default.
• W2891791005 hasConceptScore W2891791005C2780559512 @default.
• W2891791005 hasConceptScore W2891791005C2993667909 @default.
• W2891791005 hasConceptScore W2891791005C53673613 @default.
• W2891791005 hasConceptScore W2891791005C544855455 @default.
• W2891791005 hasConceptScore W2891791005C71924100 @default.
• W2891791005 hasConceptScore W2891791005C98274493 @default.
• W2891791005 hasIssue "7" @default.
• W2891791005 hasLocation W28917910051 @default.
• W2891791005 hasLocation W28917910052 @default.
• W2891791005 hasOpenAccess W2891791005 @default.
• W2891791005 hasPrimaryLocation W28917910051 @default.

• next