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• W2891791754 abstract "Bifidobacterium breve (B. breve) may have a beneficial effect on allergic rhinitis (AR). The aim of the present study was to investigate whether microbial induction of regulatory T cells (Tregs) and adjustment of Th1 and Th2 responses by B. breve are associated with protection against allergic inflammation, and to identify a dose‑response association in a murine AR model. Ovalbumin (OVA)‑sensitized BALB/c mice were orally treated with different doses of B. breve [1010, 109, 107 and 105 colony forming units (CFU)]. Following nasal challenge with OVA, sneeze frequency, serum OVA‑specific immunoglobulin E (IgE) and cytokine concentrations [interleukin (IL)‑4, IL‑10, IL‑13 and interferon‑γ], splenic percentage of cluster of differentiation (CD)4+CD25+ Tregs, and morphology of the nasal mucosa were examined. Oral treatment with live B. breve at doses of 107 CFU or higher alleviated nasal mucosal injury and suppressed sneezing upon repeated administration over a 6‑week period. Furthermore, treatment with B. breve at these higher doses reduced the concentrations of serum OVA‑specific IgE, IL‑4 and IL‑10, and increased the splenic percentage of CD4+CD25+ Tregs in rhinitic mice compared with those who did not receive probiotics. In contrast, treatment with B. breve at a lower dose did not indicate any effect on sneezing frequency or mucosal morphology in this animal model, even though the splenic percentage of CD4+CD25+ Tregs increased and the concentrations of serum OVA‑specific IgE and IL‑10 declined. B. breve exerts its anti‑allergic effects by inhibiting type 2 helper T cell immune responses and enhancing CD4+CD25+ Treg activity. Sneezing was also reduced at a dose of 107 CFU or higher. The current study investigated the role of B. breve and aided in identifying the optimal dose of B. breve administration in the treatment of AR." @default.
• W2891791754 created "2018-09-27" @default.
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• W2891791754 date "2018-09-06" @default.
• W2891791754 modified "2023-10-16" @default.
• W2891791754 title "Immunomodulatory effect of Bifidobacterium�breve on experimental allergic rhinitis in BALB/c mice" @default.
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• W2891791754 doi "https://doi.org/10.3892/etm.2018.6704" @default.
• W2891791754 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6176161" @default.
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