Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891793313> ?p ?o ?g. }
- W2891793313 abstract "Calmodulin (CaM) serves as a pervasive regulatory subunit of CaV1, CaV2, and NaV1 channels, exploiting a functionally conserved carboxy-tail element to afford dynamic Ca2+-feedback of cellular excitability in neurons and cardiomyocytes. Yet this modularity counters functional adaptability, as global changes in ambient CaM indiscriminately alter its targets. Here, we demonstrate that two structurally unrelated proteins, SH3 and cysteine-rich domain (stac) and fibroblast growth factor homologous factors (fhf) selectively diminish Ca2+/CaM-regulation of CaV1 and NaV1 families, respectively. The two proteins operate on allosteric sites within upstream portions of respective channel carboxy-tails, distinct from the CaM-binding interface. Generalizing this mechanism, insertion of a short RxxK binding motif into CaV1.3 carboxy-tail confers synthetic switching of CaM regulation by Mona SH3 domain. Overall, our findings identify a general class of auxiliary proteins that modify Ca2+/CaM signaling to individual targets allowing spatial and temporal orchestration of feedback, and outline strategies for engineering Ca2+/CaM signaling to individual targets." @default.
- W2891793313 created "2018-09-27" @default.
- W2891793313 creator A5006064421 @default.
- W2891793313 creator A5009404984 @default.
- W2891793313 creator A5038005619 @default.
- W2891793313 creator A5045137391 @default.
- W2891793313 creator A5058840388 @default.
- W2891793313 creator A5070207038 @default.
- W2891793313 creator A5073140592 @default.
- W2891793313 creator A5088597105 @default.
- W2891793313 date "2018-09-10" @default.
- W2891793313 modified "2023-10-06" @default.
- W2891793313 title "Allosteric regulators selectively prevent Ca2+-feedback of CaV and NaV channels" @default.
- W2891793313 cites W1496192961 @default.
- W2891793313 cites W1504047759 @default.
- W2891793313 cites W1510439895 @default.
- W2891793313 cites W1523938232 @default.
- W2891793313 cites W1599277155 @default.
- W2891793313 cites W1601108103 @default.
- W2891793313 cites W1625435902 @default.
- W2891793313 cites W173935235 @default.
- W2891793313 cites W1877667838 @default.
- W2891793313 cites W1894020854 @default.
- W2891793313 cites W1964152667 @default.
- W2891793313 cites W1964639783 @default.
- W2891793313 cites W1965543460 @default.
- W2891793313 cites W1967803454 @default.
- W2891793313 cites W1970857342 @default.
- W2891793313 cites W1972880122 @default.
- W2891793313 cites W1975414553 @default.
- W2891793313 cites W1976471735 @default.
- W2891793313 cites W1979756389 @default.
- W2891793313 cites W1979881112 @default.
- W2891793313 cites W1984409904 @default.
- W2891793313 cites W1984987102 @default.
- W2891793313 cites W1991054672 @default.
- W2891793313 cites W1991203132 @default.
- W2891793313 cites W1995946312 @default.
- W2891793313 cites W1997424855 @default.
- W2891793313 cites W1997777027 @default.
- W2891793313 cites W1997925229 @default.
- W2891793313 cites W2001594716 @default.
- W2891793313 cites W2005143680 @default.
- W2891793313 cites W2005843441 @default.
- W2891793313 cites W2010469248 @default.
- W2891793313 cites W2010770575 @default.
- W2891793313 cites W2012179510 @default.
- W2891793313 cites W2012803142 @default.
- W2891793313 cites W2013076639 @default.
- W2891793313 cites W2015426350 @default.
- W2891793313 cites W2015593651 @default.
- W2891793313 cites W2019916099 @default.
- W2891793313 cites W2020020519 @default.
- W2891793313 cites W2024567284 @default.
- W2891793313 cites W2025357000 @default.
- W2891793313 cites W2030926410 @default.
- W2891793313 cites W2032781518 @default.
- W2891793313 cites W2036145275 @default.
- W2891793313 cites W2038397615 @default.
- W2891793313 cites W2039358114 @default.
- W2891793313 cites W2042210724 @default.
- W2891793313 cites W2045858112 @default.
- W2891793313 cites W2047253203 @default.
- W2891793313 cites W2048900664 @default.
- W2891793313 cites W2053330127 @default.
- W2891793313 cites W2054904696 @default.
- W2891793313 cites W2057269307 @default.
- W2891793313 cites W2057785882 @default.
- W2891793313 cites W2061321767 @default.
- W2891793313 cites W2064894346 @default.
- W2891793313 cites W2065033398 @default.
- W2891793313 cites W2066290601 @default.
- W2891793313 cites W2067901022 @default.
- W2891793313 cites W2069860553 @default.
- W2891793313 cites W2069955906 @default.
- W2891793313 cites W2072433937 @default.
- W2891793313 cites W2075622623 @default.
- W2891793313 cites W2082105256 @default.
- W2891793313 cites W2082277627 @default.
- W2891793313 cites W2084765139 @default.
- W2891793313 cites W2087062865 @default.
- W2891793313 cites W2087902062 @default.
- W2891793313 cites W2094711023 @default.
- W2891793313 cites W2095345152 @default.
- W2891793313 cites W2095470391 @default.
- W2891793313 cites W2096264533 @default.
- W2891793313 cites W2097979065 @default.
- W2891793313 cites W2098486791 @default.
- W2891793313 cites W2102922842 @default.
- W2891793313 cites W2110260167 @default.
- W2891793313 cites W2114635190 @default.
- W2891793313 cites W2116234307 @default.
- W2891793313 cites W2120096061 @default.
- W2891793313 cites W2121234157 @default.
- W2891793313 cites W2122892477 @default.
- W2891793313 cites W2123347941 @default.
- W2891793313 cites W2130151244 @default.
- W2891793313 cites W2132926880 @default.
- W2891793313 cites W2141479114 @default.
- W2891793313 cites W2149905147 @default.