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• W2891794985 abstract "Maternal overnutrition has been associated with increased susceptibility to develop obesity and neurological disorders later in life. Most epidemiological as well as experimental studies have focused on the metabolic consequences across generations following an early developmental nutritional insult. Recently, it has been shown that maternal high-fat diet (HFD) affects third-generation female body mass via the paternal lineage. We showed here that the offspring born to HFD ancestors displayed addictive-like behaviors as well as obesity and insulin resistance up to the third generation in the absence of any further exposure to HFD. These findings, implicate that the male germ line is a major player in transferring phenotypic traits. These behavioral and physiological alterations were paralleled by reduced striatal dopamine levels and increased dopamine 2 receptor density. Interestingly, by the third generation a clear gender segregation emerged, where females showed addictive-like behaviors while male HFD offspring showed an obesogenic phenotype. However, methylome profiling of F1 and F2 sperm revealed no significant difference between the offspring groups, suggesting that the sperm methylome might not be the major carrier for the transmission of the phenotypes observed in our mouse model. Together, our study for the first time demonstrates that maternal HFD insult causes sustained alterations of the mesolimbic dopaminergic system suggestive of a predisposition to develop obesity and addictive-like behaviors across multiple generations." @default.
• W2891794985 created "2018-09-27" @default.
• W2891794985 creator A5007014214 @default.
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• W2891794985 date "2018-10-12" @default.
• W2891794985 modified "2023-10-17" @default.
• W2891794985 title "Transgenerational transmission of hedonic behaviors and metabolic phenotypes induced by maternal overnutrition" @default.
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• W2891794985 doi "https://doi.org/10.1038/s41398-018-0243-2" @default.
• W2891794985 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6185972" @default.
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• W2891794985 hasPublicationYear "2018" @default.
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