FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891799091> ?p ?o ?g. }

• W2891799091 endingPage "191" @default.
• W2891799091 startingPage "181" @default.
• W2891799091 abstract "Obesity is a metabolic disorder that predisposes to numerous diseases and has become a major global public health concern. Cafeteria diet (CAF) is the animal model used for the study of obesity that more closely reflects Western diet habits. Previously, we described that CAF administration for 60 days induces obesity in female rats and their fetuses develop macrosomia. Given that, in our model, rats are not genetically modified and that obese mothers were fed standard chow during pregnancy, the aim of the current study was to test the hypothesis that obesity alters the intrauterine environment prior to pregnancy, and this may explain the exacerbated fetal weight gain. We found that uteri from obese rats during the estrous phase developed insulin resistance through mechanisms that involve the induction of uterine hypoxia and the down-regulation of the insulin receptor gene. Moreover, uterine cell proliferation was induced by obesity concomitantly with the reduction in the uterine contractile response to a β2 AR agonist, salbutamol, and this may be consequence of the down-regulation in the uterine β2 AR expression. We conclude that CAF-induced obesity alters the uterine environment in rats during the estrous phase and may cause the fetal macrosomia previously described by us in obese animals. The lower sensitivity of the uterus to a relaxation stimulus (salbutamol) is not a minor fact given that for implantation to occur the uterus must be relaxed for embryo nidation. Thus, the alteration in the uterine quiescence may impair implantation and, consequently, the foregoing pregnancy." @default.
• W2891799091 created "2018-09-27" @default.
• W2891799091 creator A5001653731 @default.
• W2891799091 creator A5006271172 @default.
• W2891799091 creator A5010007659 @default.
• W2891799091 creator A5041365887 @default.
• W2891799091 creator A5075935351 @default.
• W2891799091 date "2018-12-01" @default.
• W2891799091 modified "2023-10-18" @default.
• W2891799091 title "Obesity alters the uterine environment before pregnancy" @default.
• W2891799091 cites W1936932612 @default.
• W2891799091 cites W1973493239 @default.
• W2891799091 cites W1990483086 @default.
• W2891799091 cites W1991498411 @default.
• W2891799091 cites W1992846341 @default.
• W2891799091 cites W1992867238 @default.
• W2891799091 cites W1993812967 @default.
• W2891799091 cites W2001666774 @default.
• W2891799091 cites W2001768508 @default.
• W2891799091 cites W2009181620 @default.
• W2891799091 cites W2019759067 @default.
• W2891799091 cites W2033958147 @default.
• W2891799091 cites W2036939737 @default.
• W2891799091 cites W2052147623 @default.
• W2891799091 cites W2054410490 @default.
• W2891799091 cites W2054709028 @default.
• W2891799091 cites W2061877552 @default.
• W2891799091 cites W2066715281 @default.
• W2891799091 cites W2071529705 @default.
• W2891799091 cites W2072973008 @default.
• W2891799091 cites W2080024994 @default.
• W2891799091 cites W2088619192 @default.
• W2891799091 cites W2089984829 @default.
• W2891799091 cites W2097511872 @default.
• W2891799091 cites W2101715194 @default.
• W2891799091 cites W2104168724 @default.
• W2891799091 cites W2106381484 @default.
• W2891799091 cites W2109870736 @default.
• W2891799091 cites W2122628922 @default.
• W2891799091 cites W2124263946 @default.
• W2891799091 cites W2132664219 @default.
• W2891799091 cites W2135174928 @default.
• W2891799091 cites W2145323170 @default.
• W2891799091 cites W2154605956 @default.
• W2891799091 cites W2157301576 @default.
• W2891799091 cites W2166089648 @default.
• W2891799091 cites W2171904353 @default.
• W2891799091 cites W2182278065 @default.
• W2891799091 cites W2224640355 @default.
• W2891799091 cites W2259238639 @default.
• W2891799091 cites W2411596292 @default.
• W2891799091 cites W2539742027 @default.
• W2891799091 cites W2552500419 @default.
• W2891799091 cites W2559454040 @default.
• W2891799091 cites W2582925506 @default.
• W2891799091 cites W2620726325 @default.
• W2891799091 cites W2883533542 @default.
• W2891799091 cites W2884770885 @default.
• W2891799091 doi "https://doi.org/10.1016/j.jnutbio.2018.09.009" @default.
• W2891799091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30300837" @default.
• W2891799091 hasPublicationYear "2018" @default.
• W2891799091 type Work @default.
• W2891799091 sameAs 2891799091 @default.
• W2891799091 citedByCount "2" @default.
• W2891799091 countsByYear W28917990912022 @default.
• W2891799091 countsByYear W28917990912023 @default.
• W2891799091 crossrefType "journal-article" @default.
• W2891799091 hasAuthorship W2891799091A5001653731 @default.
• W2891799091 hasAuthorship W2891799091A5006271172 @default.
• W2891799091 hasAuthorship W2891799091A5010007659 @default.
• W2891799091 hasAuthorship W2891799091A5041365887 @default.
• W2891799091 hasAuthorship W2891799091A5075935351 @default.
• W2891799091 hasBestOaLocation W28917990912 @default.
• W2891799091 hasConcept C126322002 @default.
• W2891799091 hasConcept C134018914 @default.
• W2891799091 hasConcept C172680121 @default.
• W2891799091 hasConcept C1998276 @default.
• W2891799091 hasConcept C201614185 @default.
• W2891799091 hasConcept C2776042228 @default.
• W2891799091 hasConcept C2777394947 @default.
• W2891799091 hasConcept C2779066055 @default.
• W2891799091 hasConcept C2779234561 @default.
• W2891799091 hasConcept C511355011 @default.
• W2891799091 hasConcept C54355233 @default.
• W2891799091 hasConcept C71924100 @default.
• W2891799091 hasConcept C86803240 @default.
• W2891799091 hasConceptScore W2891799091C126322002 @default.
• W2891799091 hasConceptScore W2891799091C134018914 @default.
• W2891799091 hasConceptScore W2891799091C172680121 @default.
• W2891799091 hasConceptScore W2891799091C1998276 @default.
• W2891799091 hasConceptScore W2891799091C201614185 @default.
• W2891799091 hasConceptScore W2891799091C2776042228 @default.
• W2891799091 hasConceptScore W2891799091C2777394947 @default.
• W2891799091 hasConceptScore W2891799091C2779066055 @default.
• W2891799091 hasConceptScore W2891799091C2779234561 @default.
• W2891799091 hasConceptScore W2891799091C511355011 @default.
• W2891799091 hasConceptScore W2891799091C54355233 @default.
• W2891799091 hasConceptScore W2891799091C71924100 @default.

• next