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• W2891800436 abstract "The most widespread childhood cancer located outside of the brain is neuroblastoma (NB). It accounts for 12% of all childhood cancer-related deaths and affects 10.5 million children annually, usually in infants younger than five. Toxic rounds of surgery, chemotherapy, and radiation still fail to provide relapse-free survival in high-risk children.  In addition to tumor reduction, the more severe methods obliterate the child’s protective immune system. Patient’s hematopoietic stem cells (harvested from the bone marrow or cytokine-mobilized blood) is therefore collected before treatment and saved to allow for later re-engraftment of immune stem cells. One continuing concern is that the autologous transplant samples harbor contaminating NB cells. We are currently testing oncolytic virotherapy as a self-replicating and easily administered tool to remove any residual cancer cells from the auto-transplant sample. Myxoma Virus (MYXV) has already been proven naturally selective for the purging of other classes of cancer cells from bone marrow samples. MYXV also lacks the ability to productively infect normal primary CD34+ hematopoietic stem cells.  The current study shows that MYXV can infect and kill the human neuroblastoma cell line, SK-N-AS, in vitro. In addition, when cells are treated with MYXV prior to tail vein injection into NSG mice, we observe a decrease in tumor engraftment in vivo,and this is accompanied by reduced disease phenotypes. Results from this study also provide insight to suggestions for increasing MYXV treatment efficiency. We have established a xenograft model to test for the ex vivo purging of contaminating neuroblastoma cells from transplant samples. We support the continued investigation of MYXV as a potential therapeutic strategy for the treatment of the pediatric disease neuroblastoma. ( en )" @default.
• W2891800436 created "2018-09-27" @default.
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• W2891800436 date "2013-01-01" @default.
• W2891800436 modified "2023-09-27" @default.
• W2891800436 title "Myxoma Virus Therapy for Neuroblastoma" @default.
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