Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891800928> ?p ?o ?g. }
- W2891800928 abstract "Abstract Brain mechanisms responsible for errors during cognitive tasks are poorly understood, particularly in adolescents with attention-deficit hyperactivity disorder (ADHD). Using subject-specific multimodal imaging (EEG, MRI, behavior) during flanker task performance by a sample of 94 human adolescents (mean age = 15.5 years, 50% female) with varying degrees of ADHD symptomatology, we examined the degree to which amplitudes of source-resolved event-related potentials (ERPs) from brain independent components within a critical (but often ignored) period in the action selection process, the stimulus-response interval, predicted motor response errors (across trials) and error rates (across individuals). Reduced amplitudes of Frontocentral P3 (peaking at approximately 390 milliseconds in stimulus-locked ERPs) and Pre-Movement Positivity (PMP, peaking at approximately 110 milliseconds pre-response in response-locked ERPs) in projections from posterior medial frontal cortex (pMFC) predicted erroneous responses, and reduced amplitude of PMP predicted a larger participant error rate. After regressing stimulus-from response-locked ERPs, we concluded that errors primarily depended upon response selection processes reflected in PMP amplitude. Finally, mediation analyses showed that smaller PMPs on correct response trials was associated with the higher frequency of errors committed by adolescents with more ADHD symptoms. These results bolster the importance of pMFC in action selection and support the possible value of using PMP as an intervention target to remediate performance deficits in ADHD." @default.
- W2891800928 created "2018-09-27" @default.
- W2891800928 creator A5012933125 @default.
- W2891800928 creator A5039999379 @default.
- W2891800928 creator A5053345339 @default.
- W2891800928 creator A5082589963 @default.
- W2891800928 date "2018-09-09" @default.
- W2891800928 modified "2023-09-26" @default.
- W2891800928 title "Reduced Medial Frontal Positivity During the Stimulus-Response Interval Precedes Action Errors and Explains Task Deficits in Attention-Deficit Hyperactivity Disorder" @default.
- W2891800928 cites W1042512276 @default.
- W2891800928 cites W1195547771 @default.
- W2891800928 cites W1483092065 @default.
- W2891800928 cites W1490419602 @default.
- W2891800928 cites W1506091216 @default.
- W2891800928 cites W1529954550 @default.
- W2891800928 cites W1572058604 @default.
- W2891800928 cites W1650692308 @default.
- W2891800928 cites W1769300437 @default.
- W2891800928 cites W1838028311 @default.
- W2891800928 cites W1900233909 @default.
- W2891800928 cites W1963719351 @default.
- W2891800928 cites W1964741907 @default.
- W2891800928 cites W1966003128 @default.
- W2891800928 cites W1967970656 @default.
- W2891800928 cites W1976104061 @default.
- W2891800928 cites W1983276750 @default.
- W2891800928 cites W1991491984 @default.
- W2891800928 cites W1991911667 @default.
- W2891800928 cites W1997027149 @default.
- W2891800928 cites W2000544704 @default.
- W2891800928 cites W2007024003 @default.
- W2891800928 cites W2028017636 @default.
- W2891800928 cites W2029386843 @default.
- W2891800928 cites W2034614101 @default.
- W2891800928 cites W2036056692 @default.
- W2891800928 cites W2036686623 @default.
- W2891800928 cites W2039854165 @default.
- W2891800928 cites W2039948107 @default.
- W2891800928 cites W2044950395 @default.
- W2891800928 cites W2055414800 @default.
- W2891800928 cites W2056964351 @default.
- W2891800928 cites W2058046532 @default.
- W2891800928 cites W2058317558 @default.
- W2891800928 cites W2060919139 @default.
- W2891800928 cites W2060971324 @default.
- W2891800928 cites W2062689759 @default.
- W2891800928 cites W2063473805 @default.
- W2891800928 cites W2063536906 @default.
- W2891800928 cites W2064103507 @default.
- W2891800928 cites W2064794011 @default.
- W2891800928 cites W2069758018 @default.
- W2891800928 cites W2072170505 @default.
- W2891800928 cites W2081288663 @default.
- W2891800928 cites W2081722843 @default.
- W2891800928 cites W2085677001 @default.
- W2891800928 cites W2093250994 @default.
- W2891800928 cites W2093839933 @default.
- W2891800928 cites W2094583499 @default.
- W2891800928 cites W2098069002 @default.
- W2891800928 cites W2101126957 @default.
- W2891800928 cites W2102758885 @default.
- W2891800928 cites W2104057213 @default.
- W2891800928 cites W2107762576 @default.
- W2891800928 cites W2108214672 @default.
- W2891800928 cites W2108456626 @default.
- W2891800928 cites W2117140276 @default.
- W2891800928 cites W2119117306 @default.
- W2891800928 cites W2120730087 @default.
- W2891800928 cites W2128495200 @default.
- W2891800928 cites W2130514477 @default.
- W2891800928 cites W2132340226 @default.
- W2891800928 cites W2134012732 @default.
- W2891800928 cites W2137158682 @default.
- W2891800928 cites W2137598348 @default.
- W2891800928 cites W2145758129 @default.
- W2891800928 cites W2148582387 @default.
- W2891800928 cites W2155658404 @default.
- W2891800928 cites W2156390139 @default.
- W2891800928 cites W2157042985 @default.
- W2891800928 cites W2160107924 @default.
- W2891800928 cites W2162454311 @default.
- W2891800928 cites W2165453886 @default.
- W2891800928 cites W2169209827 @default.
- W2891800928 cites W2171746332 @default.
- W2891800928 cites W2172031239 @default.
- W2891800928 cites W2290314769 @default.
- W2891800928 cites W2296103515 @default.
- W2891800928 cites W2302993934 @default.
- W2891800928 cites W2418629403 @default.
- W2891800928 cites W2495861132 @default.
- W2891800928 cites W2503208244 @default.
- W2891800928 cites W2517665055 @default.
- W2891800928 cites W2774486220 @default.
- W2891800928 cites W2810187604 @default.
- W2891800928 cites W4206439534 @default.
- W2891800928 cites W4234217706 @default.
- W2891800928 cites W4234802248 @default.
- W2891800928 cites W4235215772 @default.
- W2891800928 cites W4247671683 @default.
- W2891800928 doi "https://doi.org/10.1101/412494" @default.