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- W2891801441 abstract "The Helicobacter pylori (H. pylori) infection is a determinant factor in gastric cancer (GC) development. However, the infection outcomes are variable and depend on both host and bacterial characteristics. Some host cytokines such as interleukin (IL)-1β, IL-1Ra, IL-8, IL-10 and tumor necrosis factor-α play important roles in the host immune system response to the pathogen, in the development of gastric mucosal lesions and in cell malignant transformation. Therefore, these host factors are crucial in neoplastic processes. Certain polymorphisms in genes that encode these cytokines have been associated with an increased risk of GC. On the other hand, various virulence factors found in distinct H. pylori bacterial strains, including cytotoxin-associated antigen A, vacuolating cytotoxin, duodenal ulcer promoting gene A protein, outer inflammatory protein and blood group antigen binding adhesin, have been associated with the pathogenesis of different gastric diseases. The virulent factors mentioned above allow the successful infection by the bacterium and play crucial roles in gastric mucosa lesions, including malignant transformation. Moreover, the role of host polymorphisms and bacterial virulence factors in gastric carcinogenesis seems to vary among different countries and populations. The identification of host and bacterium factors that are associated with an increased risk of GC development may be useful in determining the prognosis of infection in patients, what could help in clinical decision-making and in providing of an optimized clinical approach." @default.
- W2891801441 created "2018-09-27" @default.
- W2891801441 creator A5049714540 @default.
- W2891801441 creator A5075054907 @default.
- W2891801441 creator A5081651823 @default.
- W2891801441 date "2018-09-14" @default.
- W2891801441 modified "2023-09-27" @default.
- W2891801441 title "Role of polymorphisms in genes that encode cytokines and Helicobacter pylori virulence factors in gastric carcinogenesis" @default.
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- W2891801441 doi "https://doi.org/10.5306/wjco.v9.i5.83" @default.
- W2891801441 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6153128" @default.
- W2891801441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30254963" @default.
- W2891801441 hasPublicationYear "2018" @default.
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