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• W2891804893 abstract "Previous studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of CCL3/4 for centrocyte interactions with follicular T cells and regulation of humoral immunity is poorly understood. We found that CCL3 promotes chemotaxis of Tfr cells ex vivo. Two-photon imaging revealed that B cells-intrinsic production of CCL3 promotes their probing by follicular regulatory T cells (Tfr) within GCs of murine lymph nodes. Overall this study suggests that CCL3 facilitates direct interactions of foreign antigen-specific GC B cells and their negative regulation with Tfr cells in vivo." @default.
• W2891804893 created "2018-09-27" @default.
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• W2891804893 date "2018-09-13" @default.
• W2891804893 modified "2023-10-05" @default.
• W2891804893 title "CCL3 Promotes Germinal Center B Cells Sampling by Follicular Regulatory T Cells in Murine Lymph Nodes" @default.
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• W2891804893 doi "https://doi.org/10.3389/fimmu.2018.02044" @default.
• W2891804893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6146081" @default.
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