Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891805717> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2891805717 endingPage "33701" @default.
- W2891805717 startingPage "33694" @default.
- W2891805717 abstract "// Joshua N. Kellner 1 , Eric Yvon 3 and Simrit Parmar 1, 2 1 Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 2 Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 3 Department of Medicine, Hematology and Oncology, George Washington University School of Medicine, Washington, D.C, USA Correspondence to: Joshua N. Kellner, email: jnkellner@mdanderson.org Keywords: regulatory T cells; immunotherapy; cell therapy; ex vivo expansion; cord blood Received: June 19, 2018 Accepted: August 20, 2018 Published: September 14, 2018 ABSTRACT Regulatory T cells (Tregs) are an important component of the immune system involved in regulation of immune cell proliferation and inflammatory responses and preventing autoimmune diseases. The use of Tregs in cellular therapy has recently been explored in clinical trials specifically evaluating the role of ex vivo expanded Tregs in the prevention of graft-versus-host disease during stem cell transplantation. The possibility of Treg use in the clinic requires clinical grade expansion of Tregs for development of cell therapy protocols and proper homing of Tregs to the intended target. Here we demonstrate a novel medium composition to expand CB Tregs, specifically upregulation the homing and activation markers CD62L and cutaneous lymphocyte antigen (CLA). CLA expression was uniquely acquired during activation of Tregs with subsequent loss or lack of expression with media change. This finding highlights the importance of proper growth conditions unique to Tregs that can alter expression of proteins and establishes a baseline for expanding marker specific Tregs that home and target unique tissues." @default.
- W2891805717 created "2018-09-27" @default.
- W2891805717 creator A5026422612 @default.
- W2891805717 creator A5038451446 @default.
- W2891805717 creator A5082887496 @default.
- W2891805717 date "2018-09-14" @default.
- W2891805717 modified "2023-10-18" @default.
- W2891805717 title "<i>Ex vivo</i> generation of umbilical cord blood T regulatory cells expressing the homing markers CD62L and cutaneous lymphocyte antigen" @default.
- W2891805717 cites W1902927666 @default.
- W2891805717 cites W1974728044 @default.
- W2891805717 cites W1993310853 @default.
- W2891805717 cites W2006348119 @default.
- W2891805717 cites W2011593628 @default.
- W2891805717 cites W2025743850 @default.
- W2891805717 cites W2029200807 @default.
- W2891805717 cites W2039958325 @default.
- W2891805717 cites W2044696138 @default.
- W2891805717 cites W2045360347 @default.
- W2891805717 cites W2080967693 @default.
- W2891805717 cites W2086030126 @default.
- W2891805717 cites W2090807791 @default.
- W2891805717 cites W2107631420 @default.
- W2891805717 cites W2145353379 @default.
- W2891805717 cites W2153534792 @default.
- W2891805717 cites W2173141813 @default.
- W2891805717 cites W2332517313 @default.
- W2891805717 cites W2337931770 @default.
- W2891805717 cites W2563389621 @default.
- W2891805717 cites W2781864149 @default.
- W2891805717 cites W2799492286 @default.
- W2891805717 doi "https://doi.org/10.18632/oncotarget.26097" @default.
- W2891805717 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6154753" @default.
- W2891805717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30263095" @default.
- W2891805717 hasPublicationYear "2018" @default.
- W2891805717 type Work @default.
- W2891805717 sameAs 2891805717 @default.
- W2891805717 citedByCount "2" @default.
- W2891805717 countsByYear W28918057172023 @default.
- W2891805717 crossrefType "journal-article" @default.
- W2891805717 hasAuthorship W2891805717A5026422612 @default.
- W2891805717 hasAuthorship W2891805717A5038451446 @default.
- W2891805717 hasAuthorship W2891805717A5082887496 @default.
- W2891805717 hasBestOaLocation W28918057171 @default.
- W2891805717 hasConcept C150903083 @default.
- W2891805717 hasConcept C151872237 @default.
- W2891805717 hasConcept C18903297 @default.
- W2891805717 hasConcept C194409129 @default.
- W2891805717 hasConcept C203014093 @default.
- W2891805717 hasConcept C207001950 @default.
- W2891805717 hasConcept C26291073 @default.
- W2891805717 hasConcept C2776090121 @default.
- W2891805717 hasConcept C2777701055 @default.
- W2891805717 hasConcept C28328180 @default.
- W2891805717 hasConcept C502942594 @default.
- W2891805717 hasConcept C54355233 @default.
- W2891805717 hasConcept C71924100 @default.
- W2891805717 hasConcept C86803240 @default.
- W2891805717 hasConcept C8891405 @default.
- W2891805717 hasConceptScore W2891805717C150903083 @default.
- W2891805717 hasConceptScore W2891805717C151872237 @default.
- W2891805717 hasConceptScore W2891805717C18903297 @default.
- W2891805717 hasConceptScore W2891805717C194409129 @default.
- W2891805717 hasConceptScore W2891805717C203014093 @default.
- W2891805717 hasConceptScore W2891805717C207001950 @default.
- W2891805717 hasConceptScore W2891805717C26291073 @default.
- W2891805717 hasConceptScore W2891805717C2776090121 @default.
- W2891805717 hasConceptScore W2891805717C2777701055 @default.
- W2891805717 hasConceptScore W2891805717C28328180 @default.
- W2891805717 hasConceptScore W2891805717C502942594 @default.
- W2891805717 hasConceptScore W2891805717C54355233 @default.
- W2891805717 hasConceptScore W2891805717C71924100 @default.
- W2891805717 hasConceptScore W2891805717C86803240 @default.
- W2891805717 hasConceptScore W2891805717C8891405 @default.
- W2891805717 hasIssue "72" @default.
- W2891805717 hasLocation W28918057171 @default.
- W2891805717 hasLocation W28918057172 @default.
- W2891805717 hasLocation W28918057173 @default.
- W2891805717 hasLocation W28918057174 @default.
- W2891805717 hasOpenAccess W2891805717 @default.
- W2891805717 hasPrimaryLocation W28918057171 @default.
- W2891805717 hasRelatedWork W1996150995 @default.
- W2891805717 hasRelatedWork W2023771859 @default.
- W2891805717 hasRelatedWork W2049552043 @default.
- W2891805717 hasRelatedWork W2088855571 @default.
- W2891805717 hasRelatedWork W2106314840 @default.
- W2891805717 hasRelatedWork W2114785263 @default.
- W2891805717 hasRelatedWork W2165882786 @default.
- W2891805717 hasRelatedWork W2279727045 @default.
- W2891805717 hasRelatedWork W2380021556 @default.
- W2891805717 hasRelatedWork W3031281572 @default.
- W2891805717 hasVolume "9" @default.
- W2891805717 isParatext "false" @default.
- W2891805717 isRetracted "false" @default.
- W2891805717 magId "2891805717" @default.
- W2891805717 workType "article" @default.