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• W2891806227 abstract "ABSTRACT Recent studies have revealed immunological memory of NK cells. Short-term in vitro cytokine stimulation also induces NK cell memory, but heterogeneous cell subsets within the cytokine-induced memory-like (CIML) NK cells has not been elucidated. Here we found that the dominant cell subset in human CIML NK cells are immature CD56 bright CD62L + cells, and they were selectively expanded CD56 bright CD16 - CD62L + NK cells. Although these cells acquired KIR expression after the cytokine stimulation, sustained NKG2A expression inhibits cytotoxicity against HLA-E + target cells. In contrast, another checkpoint molecule LAG-3 is induced mainly on KIR + NKG2C + minor CIML NK cells. Our findings imply targeting NKG2A and LAG-3 should be considered for CIML NK cell-based immunotherapy." @default.
• W2891806227 created "2018-09-27" @default.
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• W2891806227 date "2018-09-09" @default.
• W2891806227 modified "2023-10-18" @default.
• W2891806227 title "The CD56bright CD62L+ NKG2A+ immature cell subset is dominantly expanded in human cytokine-induced memory-like NK cells" @default.
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• W2891806227 doi "https://doi.org/10.1101/405134" @default.
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