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- W2891806980 abstract "A hallmark of heart failure is mitochondrial dysfunction leading to a bioenergetics imbalance in the myocardium. Consequently, there is much interest in targeting mitochondrial abnormalities to attenuate the pathogenesis of heart failure. This review discusses (i) how electron microscopy (EM) techniques have been fundamental for the current understanding of mitochondrial structure–function, (ii) the paradigm shift in resolutions now achievable by 3‐D EM techniques due to the introduction of direct detection devices and phase plate technology, and (iii) the application of EM for unravelling mitochondrial pathological remodelling in heart failure. We further consider the tremendous potential of multi‐scale EM techniques for the development of therapeutics, structure‐based ligand design and for delineating how a drug elicits nanostructural effects at the molecular, organelle and cellular levels. In conclusion, 3‐D EM techniques have entered a new era of structural biology and are poised to play a pivotal role in discovering new therapies targeting mitochondria for treating heart failure. Linked Articles This article is part of a themed section on Mitochondrial Pharmacology: Featured Mechanisms and Approaches for Therapy Translation. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.22/issuetoc" @default.
- W2891806980 created "2018-09-27" @default.
- W2891806980 creator A5016975298 @default.
- W2891806980 creator A5031128645 @default.
- W2891806980 creator A5047439475 @default.
- W2891806980 date "2018-10-25" @default.
- W2891806980 modified "2023-10-05" @default.
- W2891806980 title "Three‐dimensional electron microscopy techniques for unravelling mitochondrial dysfunction in heart failure and identification of new pharmacological targets" @default.
- W2891806980 cites W1480391127 @default.
- W2891806980 cites W1526441935 @default.
- W2891806980 cites W1627266444 @default.
- W2891806980 cites W1804633940 @default.
- W2891806980 cites W1963950126 @default.
- W2891806980 cites W1965109791 @default.
- W2891806980 cites W1965586048 @default.
- W2891806980 cites W1965637518 @default.
- W2891806980 cites W1966140207 @default.
- W2891806980 cites W1966316346 @default.
- W2891806980 cites W1971411282 @default.
- W2891806980 cites W1971743321 @default.
- W2891806980 cites W1976770854 @default.
- W2891806980 cites W1977748495 @default.
- W2891806980 cites W1985754511 @default.
- W2891806980 cites W1986248905 @default.
- W2891806980 cites W1986542470 @default.
- W2891806980 cites W1986996580 @default.
- W2891806980 cites W1991774783 @default.
- W2891806980 cites W1996623427 @default.
- W2891806980 cites W1996739007 @default.
- W2891806980 cites W1997317213 @default.
- W2891806980 cites W2001807631 @default.
- W2891806980 cites W2001923477 @default.
- W2891806980 cites W2003773845 @default.
- W2891806980 cites W2004277164 @default.
- W2891806980 cites W2009909952 @default.
- W2891806980 cites W2015650234 @default.
- W2891806980 cites W2019087987 @default.
- W2891806980 cites W2019186061 @default.
- W2891806980 cites W2021129026 @default.
- W2891806980 cites W2025681990 @default.
- W2891806980 cites W2026540198 @default.
- W2891806980 cites W2031972450 @default.
- W2891806980 cites W2032720768 @default.
- W2891806980 cites W2034282653 @default.
- W2891806980 cites W2038665424 @default.
- W2891806980 cites W2039276913 @default.
- W2891806980 cites W2049312885 @default.
- W2891806980 cites W2049325063 @default.
- W2891806980 cites W2051925784 @default.
- W2891806980 cites W2055996630 @default.
- W2891806980 cites W2057582542 @default.
- W2891806980 cites W2059009119 @default.
- W2891806980 cites W2060453644 @default.
- W2891806980 cites W2064270413 @default.
- W2891806980 cites W2067635405 @default.
- W2891806980 cites W2068049531 @default.
- W2891806980 cites W2069717173 @default.
- W2891806980 cites W2070390686 @default.
- W2891806980 cites W2072670197 @default.
- W2891806980 cites W2074052524 @default.
- W2891806980 cites W2074505930 @default.
- W2891806980 cites W2075046972 @default.
- W2891806980 cites W2077686023 @default.
- W2891806980 cites W2080859880 @default.
- W2891806980 cites W2085229930 @default.
- W2891806980 cites W2085367705 @default.
- W2891806980 cites W2094837989 @default.
- W2891806980 cites W2095344236 @default.
- W2891806980 cites W2097049860 @default.
- W2891806980 cites W2099837354 @default.
- W2891806980 cites W2101500875 @default.
- W2891806980 cites W2103309568 @default.
- W2891806980 cites W2103972113 @default.
- W2891806980 cites W2113959582 @default.
- W2891806980 cites W2115322996 @default.
- W2891806980 cites W2116048591 @default.
- W2891806980 cites W2116562304 @default.
- W2891806980 cites W2120521980 @default.
- W2891806980 cites W2121580924 @default.
- W2891806980 cites W2125798809 @default.
- W2891806980 cites W2127185496 @default.
- W2891806980 cites W2129632684 @default.
- W2891806980 cites W2130758099 @default.
- W2891806980 cites W2131226021 @default.
- W2891806980 cites W2131386049 @default.
- W2891806980 cites W2132629607 @default.
- W2891806980 cites W2133232243 @default.
- W2891806980 cites W2136045787 @default.
- W2891806980 cites W2136864660 @default.
- W2891806980 cites W2138760860 @default.
- W2891806980 cites W2142344615 @default.
- W2891806980 cites W2149108521 @default.
- W2891806980 cites W2151602360 @default.
- W2891806980 cites W2152674951 @default.
- W2891806980 cites W2152865365 @default.
- W2891806980 cites W2160660790 @default.
- W2891806980 cites W2165016093 @default.
- W2891806980 cites W2172127581 @default.