Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891808973> ?p ?o ?g. }
- W2891808973 endingPage "2722" @default.
- W2891808973 startingPage "2709" @default.
- W2891808973 abstract "The proper assembly of neural circuits depends on the process of synaptogenesis, or the formation of synapses between partner neurons. Using the dopaminergic PDE neurons in C. elegans, we developed an in vivo system to study the earliest steps of the formation of en passant presynaptic specializations behind an extending growth cone. We find that presynaptic materials coalesce into puncta in as little as a few minutes and that both synaptic vesicle (SV) and active zone (AZ) proteins arrive nearly simultaneously at the nascent sites of synapse formation. We show that precise regulation of UNC-104/Kinesin-3 determines the distribution of SV proteins along the axon. The localization of AZ proteins to en passant puncta, however, is largely independent of the major axonal kinesins: UNC-104/Kinesin-3 and UNC-116/Kinesin-1. Moreover, AZ proteins play a crucial role in recruiting and tethering SV precursors (SVPs)." @default.
- W2891808973 created "2018-09-27" @default.
- W2891808973 creator A5067304730 @default.
- W2891808973 creator A5079443430 @default.
- W2891808973 creator A5087904752 @default.
- W2891808973 date "2018-09-01" @default.
- W2891808973 modified "2023-10-12" @default.
- W2891808973 title "Rapid Assembly of Presynaptic Materials behind the Growth Cone in Dopaminergic Neurons Is Mediated by Precise Regulation of Axonal Transport" @default.
- W2891808973 cites W1521104469 @default.
- W2891808973 cites W1887408233 @default.
- W2891808973 cites W1963760943 @default.
- W2891808973 cites W1969600766 @default.
- W2891808973 cites W1971480441 @default.
- W2891808973 cites W1973160416 @default.
- W2891808973 cites W1973951644 @default.
- W2891808973 cites W1983542762 @default.
- W2891808973 cites W1999369847 @default.
- W2891808973 cites W2012855723 @default.
- W2891808973 cites W2015752601 @default.
- W2891808973 cites W2017957177 @default.
- W2891808973 cites W2019116271 @default.
- W2891808973 cites W2026899274 @default.
- W2891808973 cites W2029120000 @default.
- W2891808973 cites W2031787097 @default.
- W2891808973 cites W2035441746 @default.
- W2891808973 cites W2041733763 @default.
- W2891808973 cites W2042920344 @default.
- W2891808973 cites W2047250323 @default.
- W2891808973 cites W2049924082 @default.
- W2891808973 cites W2050692084 @default.
- W2891808973 cites W2060384627 @default.
- W2891808973 cites W2064226680 @default.
- W2891808973 cites W2071115662 @default.
- W2891808973 cites W2092326283 @default.
- W2891808973 cites W2093549646 @default.
- W2891808973 cites W2102548112 @default.
- W2891808973 cites W2108024591 @default.
- W2891808973 cites W2114512871 @default.
- W2891808973 cites W2115129558 @default.
- W2891808973 cites W2134076303 @default.
- W2891808973 cites W2151889253 @default.
- W2891808973 cites W2165554927 @default.
- W2891808973 cites W2287904753 @default.
- W2891808973 cites W2302615100 @default.
- W2891808973 cites W2344063409 @default.
- W2891808973 cites W2512669502 @default.
- W2891808973 cites W2518059955 @default.
- W2891808973 cites W2539080302 @default.
- W2891808973 cites W2607503492 @default.
- W2891808973 cites W2620802887 @default.
- W2891808973 cites W2756048632 @default.
- W2891808973 cites W2787582141 @default.
- W2891808973 cites W325692610 @default.
- W2891808973 doi "https://doi.org/10.1016/j.celrep.2018.07.096" @default.
- W2891808973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6179448" @default.
- W2891808973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30184504" @default.
- W2891808973 hasPublicationYear "2018" @default.
- W2891808973 type Work @default.
- W2891808973 sameAs 2891808973 @default.
- W2891808973 citedByCount "26" @default.
- W2891808973 countsByYear W28918089732019 @default.
- W2891808973 countsByYear W28918089732020 @default.
- W2891808973 countsByYear W28918089732021 @default.
- W2891808973 countsByYear W28918089732022 @default.
- W2891808973 countsByYear W28918089732023 @default.
- W2891808973 crossrefType "journal-article" @default.
- W2891808973 hasAuthorship W2891808973A5067304730 @default.
- W2891808973 hasAuthorship W2891808973A5079443430 @default.
- W2891808973 hasAuthorship W2891808973A5087904752 @default.
- W2891808973 hasBestOaLocation W28918089731 @default.
- W2891808973 hasConcept C127445978 @default.
- W2891808973 hasConcept C130316041 @default.
- W2891808973 hasConcept C135903288 @default.
- W2891808973 hasConcept C148785051 @default.
- W2891808973 hasConcept C169760540 @default.
- W2891808973 hasConcept C185592680 @default.
- W2891808973 hasConcept C187102610 @default.
- W2891808973 hasConcept C20418707 @default.
- W2891808973 hasConcept C2779530196 @default.
- W2891808973 hasConcept C2909795284 @default.
- W2891808973 hasConcept C41625074 @default.
- W2891808973 hasConcept C55493867 @default.
- W2891808973 hasConcept C59006786 @default.
- W2891808973 hasConcept C65232495 @default.
- W2891808973 hasConcept C70192387 @default.
- W2891808973 hasConcept C86803240 @default.
- W2891808973 hasConcept C95444343 @default.
- W2891808973 hasConceptScore W2891808973C127445978 @default.
- W2891808973 hasConceptScore W2891808973C130316041 @default.
- W2891808973 hasConceptScore W2891808973C135903288 @default.
- W2891808973 hasConceptScore W2891808973C148785051 @default.
- W2891808973 hasConceptScore W2891808973C169760540 @default.
- W2891808973 hasConceptScore W2891808973C185592680 @default.
- W2891808973 hasConceptScore W2891808973C187102610 @default.
- W2891808973 hasConceptScore W2891808973C20418707 @default.
- W2891808973 hasConceptScore W2891808973C2779530196 @default.
- W2891808973 hasConceptScore W2891808973C2909795284 @default.
- W2891808973 hasConceptScore W2891808973C41625074 @default.