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- W2891810721 abstract "Endothelial-to-mesenchymal transition (EndMT) is a process in which endothelial cells lose their properties and transform into fibroblast-like cells. This transition process contributes to cardiac fibrosis, a common feature of patients with chronic heart failure. To date, no specific therapies to halt or reverse cardiac fibrosis are available, so knowledge of the underlying mechanisms of cardiac fibrosis is urgently needed. In addition, EndMT contributes to other cardiovascular pathologies such as atherosclerosis and pulmonary hypertension, but also to cancer and organ fibrosis. Remarkably, the molecular mechanisms driving EndMT are largely unknown. Epigenetics play an important role in regulating gene transcription and translation and have been implicated in the EndMT process. Therefore, epigenetics might be the missing link in unraveling the underlying mechanisms of EndMT. Here, we review the involvement of epigenetic regulators during EndMT in the context of cardiac fibrosis. The role of DNA methylation, histone modifications (acetylation and methylation), and noncoding RNAs (microRNAs, long noncoding RNAs, and circular RNAs) in the facilitation and inhibition of EndMT are discussed, and potential therapeutic epigenetic targets will be highlighted." @default.
- W2891810721 created "2018-09-27" @default.
- W2891810721 creator A5025662877 @default.
- W2891810721 creator A5030899657 @default.
- W2891810721 creator A5042273614 @default.
- W2891810721 creator A5045540833 @default.
- W2891810721 date "2018-09-01" @default.
- W2891810721 modified "2023-10-18" @default.
- W2891810721 title "Epigenetic Regulation of Endothelial-to-Mesenchymal Transition in Chronic Heart Disease" @default.
- W2891810721 cites W1503867489 @default.
- W2891810721 cites W1519629411 @default.
- W2891810721 cites W1761848048 @default.
- W2891810721 cites W1820063374 @default.
- W2891810721 cites W1925892179 @default.
- W2891810721 cites W1943962033 @default.
- W2891810721 cites W1954145299 @default.
- W2891810721 cites W1955424421 @default.
- W2891810721 cites W1966411071 @default.
- W2891810721 cites W1966557314 @default.
- W2891810721 cites W1967430005 @default.
- W2891810721 cites W1967536798 @default.
- W2891810721 cites W1969774671 @default.
- W2891810721 cites W1970242689 @default.
- W2891810721 cites W1972170164 @default.
- W2891810721 cites W1973549360 @default.
- W2891810721 cites W1974747095 @default.
- W2891810721 cites W1974848384 @default.
- W2891810721 cites W1980455524 @default.
- W2891810721 cites W1980691914 @default.
- W2891810721 cites W1981463058 @default.
- W2891810721 cites W1997453048 @default.
- W2891810721 cites W2002870320 @default.
- W2891810721 cites W2007343355 @default.
- W2891810721 cites W2007613133 @default.
- W2891810721 cites W2008978345 @default.
- W2891810721 cites W2015416439 @default.
- W2891810721 cites W2015863218 @default.
- W2891810721 cites W2022022817 @default.
- W2891810721 cites W2022774712 @default.
- W2891810721 cites W2031137884 @default.
- W2891810721 cites W2036848594 @default.
- W2891810721 cites W2037475514 @default.
- W2891810721 cites W2053648326 @default.
- W2891810721 cites W2053758959 @default.
- W2891810721 cites W2054589289 @default.
- W2891810721 cites W2057079071 @default.
- W2891810721 cites W2058835062 @default.
- W2891810721 cites W2063369009 @default.
- W2891810721 cites W2072466432 @default.
- W2891810721 cites W2073235331 @default.
- W2891810721 cites W2074125093 @default.
- W2891810721 cites W2078234036 @default.
- W2891810721 cites W2083245183 @default.
- W2891810721 cites W2084175844 @default.
- W2891810721 cites W2089288158 @default.
- W2891810721 cites W2089812396 @default.
- W2891810721 cites W2091228398 @default.
- W2891810721 cites W2092589295 @default.
- W2891810721 cites W2094247278 @default.
- W2891810721 cites W2095382041 @default.
- W2891810721 cites W2098615353 @default.
- W2891810721 cites W2100825082 @default.
- W2891810721 cites W2103328690 @default.
- W2891810721 cites W2104593525 @default.
- W2891810721 cites W2104927733 @default.
- W2891810721 cites W2106256269 @default.
- W2891810721 cites W2107387191 @default.
- W2891810721 cites W2114880343 @default.
- W2891810721 cites W2115542035 @default.
- W2891810721 cites W2115898766 @default.
- W2891810721 cites W2116934022 @default.
- W2891810721 cites W2118891188 @default.
- W2891810721 cites W2123034349 @default.
- W2891810721 cites W2129375421 @default.
- W2891810721 cites W2130275173 @default.
- W2891810721 cites W2131977410 @default.
- W2891810721 cites W2132093971 @default.
- W2891810721 cites W2134723973 @default.
- W2891810721 cites W2134873717 @default.
- W2891810721 cites W2144137532 @default.
- W2891810721 cites W2151868383 @default.
- W2891810721 cites W2155912199 @default.
- W2891810721 cites W2158421326 @default.
- W2891810721 cites W2161918376 @default.
- W2891810721 cites W2163028543 @default.
- W2891810721 cites W2163769371 @default.
- W2891810721 cites W2164717367 @default.
- W2891810721 cites W2168602111 @default.
- W2891810721 cites W2169018059 @default.
- W2891810721 cites W2171703621 @default.
- W2891810721 cites W2186518561 @default.
- W2891810721 cites W2191906041 @default.
- W2891810721 cites W2256609637 @default.
- W2891810721 cites W2263152329 @default.
- W2891810721 cites W2278300339 @default.
- W2891810721 cites W2279137994 @default.
- W2891810721 cites W2281286478 @default.
- W2891810721 cites W2285299655 @default.