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- W2891811021 abstract "Since their initial discovery, tRNAs have risen from sole adapter molecules during protein synthesis to pivotal modulators of gene expression. Through their many interactions with tRNA-associated protein factors, they play a central role in maintaining cell homeostasis, especially regarding the fine-tuning in response to a rapidly changing cellular environment. Here, we provide a perspective on current tRNA topics with a spotlight on the regulation of post-transcriptional shaping of tRNA molecules. First, we give an update on aberrant structural features that a yet functional fraction of mitochondrial tRNAs can exhibit. Then, we outline several aspects of the regulatory contribution of ribonucleases with a focus on tRNA processing versus tRNA elimination. We close with a comment on the possible consequences for the intracellular examination of nascent tRNA precursors regarding respective processing factors that have been shown to associate with the tRNA transcription machinery in alternative moonlighting functions." @default.
- W2891811021 created "2018-09-27" @default.
- W2891811021 creator A5065037321 @default.
- W2891811021 creator A5078035156 @default.
- W2891811021 date "2018-09-07" @default.
- W2891811021 modified "2023-09-24" @default.
- W2891811021 title "Post-Transcriptional Regulation of tRNA Pools To Govern the Central Dogma: A Perspective" @default.
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- W2891811021 doi "https://doi.org/10.1021/acs.biochem.8b00862" @default.
- W2891811021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30192518" @default.
- W2891811021 hasPublicationYear "2018" @default.
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