Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891811374> ?p ?o ?g. }
- W2891811374 endingPage "259" @default.
- W2891811374 startingPage "244" @default.
- W2891811374 abstract "Colorectal carcinogenesis (CRC) imposes a major health burden in developing countries. It is the third major cause of cancer deaths. Despite several treatment strategies, novel drugs are warranted to reduce the severity of this disease. Adenomatous polyps in the colon are the major culprits in CRC and found in 45% of cancers, especially in patients 60 years of age. Inflammatory polyps are currently gaining attention in CRC, and a growing body of evidence denotes the role of inflammation in CRC. Several experimental models are being employed to investigate CRC in animals, which include the APCmin/+ mouse model, Azoxymethane, Dimethyl hydrazine, and a combination of Dextran sodium sulphate and dimethyl hydrazine. During CRC progression, several signal transduction pathways are activated. Among the major signal transduction pathways are p53, Transforming growth factor beta, Wnt/β-catenin, Delta Notch, Hippo signalling, nuclear factor erythroid 2-related factor 2 and Kelch-like ECH-associated protein 1 pathways. These signalling pathways collaborate with cell death mechanisms, which include apoptosis, necroptosis and autophagy, to determine cell fate. Extensive research has been carried out in our laboratory to investigate these signal transduction and cell death mechanistic pathways in CRC. This review summarizes CRC pathogenesis and the related cell death and signal transduction pathways." @default.
- W2891811374 created "2018-09-27" @default.
- W2891811374 creator A5016785458 @default.
- W2891811374 creator A5023330047 @default.
- W2891811374 creator A5036054545 @default.
- W2891811374 creator A5042728365 @default.
- W2891811374 creator A5076805273 @default.
- W2891811374 creator A5080183961 @default.
- W2891811374 date "2018-09-15" @default.
- W2891811374 modified "2023-10-01" @default.
- W2891811374 title "Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review" @default.
- W2891811374 cites W1107410486 @default.
- W2891811374 cites W1539412927 @default.
- W2891811374 cites W1544269624 @default.
- W2891811374 cites W1568284676 @default.
- W2891811374 cites W1666932156 @default.
- W2891811374 cites W1760215417 @default.
- W2891811374 cites W1804809977 @default.
- W2891811374 cites W1830146239 @default.
- W2891811374 cites W1849822941 @default.
- W2891811374 cites W1870102877 @default.
- W2891811374 cites W1886063157 @default.
- W2891811374 cites W1903736299 @default.
- W2891811374 cites W1914451604 @default.
- W2891811374 cites W1946878013 @default.
- W2891811374 cites W1963272969 @default.
- W2891811374 cites W1964081206 @default.
- W2891811374 cites W1965050683 @default.
- W2891811374 cites W1966689985 @default.
- W2891811374 cites W1969192247 @default.
- W2891811374 cites W1970936808 @default.
- W2891811374 cites W197322975 @default.
- W2891811374 cites W1974175131 @default.
- W2891811374 cites W1974257634 @default.
- W2891811374 cites W1974941717 @default.
- W2891811374 cites W1977095715 @default.
- W2891811374 cites W1977644273 @default.
- W2891811374 cites W1978976996 @default.
- W2891811374 cites W1979312360 @default.
- W2891811374 cites W1982909507 @default.
- W2891811374 cites W1985812680 @default.
- W2891811374 cites W1986412893 @default.
- W2891811374 cites W1988331499 @default.
- W2891811374 cites W1988360179 @default.
- W2891811374 cites W1990606472 @default.
- W2891811374 cites W1992171392 @default.
- W2891811374 cites W1995654099 @default.
- W2891811374 cites W1996019069 @default.
- W2891811374 cites W1996362044 @default.
- W2891811374 cites W1998304525 @default.
- W2891811374 cites W1998558839 @default.
- W2891811374 cites W1998728654 @default.
- W2891811374 cites W1999131998 @default.
- W2891811374 cites W1999718232 @default.
- W2891811374 cites W2000655317 @default.
- W2891811374 cites W2008558830 @default.
- W2891811374 cites W2009497053 @default.
- W2891811374 cites W2011134747 @default.
- W2891811374 cites W2012656458 @default.
- W2891811374 cites W2015975359 @default.
- W2891811374 cites W2017414538 @default.
- W2891811374 cites W2017971377 @default.
- W2891811374 cites W2020611733 @default.
- W2891811374 cites W2020625439 @default.
- W2891811374 cites W2031777569 @default.
- W2891811374 cites W2031777771 @default.
- W2891811374 cites W2032580087 @default.
- W2891811374 cites W2032825860 @default.
- W2891811374 cites W2041285713 @default.
- W2891811374 cites W2041337734 @default.
- W2891811374 cites W2043539979 @default.
- W2891811374 cites W2043854938 @default.
- W2891811374 cites W2044962228 @default.
- W2891811374 cites W2048359072 @default.
- W2891811374 cites W2054613638 @default.
- W2891811374 cites W2055971882 @default.
- W2891811374 cites W2056120723 @default.
- W2891811374 cites W2057794983 @default.
- W2891811374 cites W2061071136 @default.
- W2891811374 cites W2067228085 @default.
- W2891811374 cites W2067472269 @default.
- W2891811374 cites W2072573412 @default.
- W2891811374 cites W2075497099 @default.
- W2891811374 cites W2077353205 @default.
- W2891811374 cites W2083798214 @default.
- W2891811374 cites W2085653208 @default.
- W2891811374 cites W2086320165 @default.
- W2891811374 cites W2087699943 @default.
- W2891811374 cites W2089669933 @default.
- W2891811374 cites W2094147176 @default.
- W2891811374 cites W2097689183 @default.
- W2891811374 cites W2099005238 @default.
- W2891811374 cites W2099937870 @default.
- W2891811374 cites W2103031848 @default.
- W2891811374 cites W2104141293 @default.
- W2891811374 cites W2104825362 @default.
- W2891811374 cites W2105637242 @default.
- W2891811374 cites W2106649529 @default.