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- W2891812307 abstract "Soft materials that swell or change shape in response to external stimuli show extensive promise in regenerative medicine, targeted therapeutics, and soft robotics. Generally, a stimulus for shape change must interact directly with the material, limiting the types of stimuli that may be used and necessitating high stimulus concentrations. Here, we show how DNA strand-displacement controllers within hydrogels can mediate size change by interpreting, amplifying, and integrating stimuli and releasing signals that direct the response. These controllers tune the time scale and degree of DNA-crosslinked hydrogel swelling and can actuate dramatic material size change in response to <100 nM of a specific biomolecular input. Controllers can also direct swelling in response to small molecules or perform logic. The integration of these stimuli-responsive materials with biomolecular circuits is a major step towards autonomous soft robotic systems in which sensing and actuation are implemented by biomolecular reaction networks." @default.
- W2891812307 created "2018-09-27" @default.
- W2891812307 creator A5007284033 @default.
- W2891812307 creator A5062069511 @default.
- W2891812307 date "2018-09-14" @default.
- W2891812307 modified "2023-10-14" @default.
- W2891812307 title "Modular DNA strand-displacement controllers for directing material expansion" @default.
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- W2891812307 doi "https://doi.org/10.1038/s41467-018-06218-w" @default.
- W2891812307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6138645" @default.
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