Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891812619> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2891812619 endingPage "27" @default.
- W2891812619 startingPage "19" @default.
- W2891812619 abstract "Statins reduce cholesterol levels, mainly due to the impact on its synthesis in the liver. But the rate and completeness of absorption of cholesterol in the intestine are also affect the lipid spectrum of blood. Ezetimibe is one of the first drugs that block this process. The objective of this work — to examine the safety and efficacy of low-dose combined lipid-lowering therapy compared with aggressive statin therapy in patients with acute myocardial infarction. A total of 70 patients with acute myocardial infarction admitted to hospital within the first 24 hours (mean 5.2 ± 1.0 h) after symptoms onset. Patients were randomized into two groups: first one — 35 patients receiving low-dose combination of atorvastatin 10 mg and ezetimibe 10 mg (A10/E10), second one — 35 patients treated with atorvastatin 40 mg (A40) on the background of basic therapy. Combined therapy was similar to atorvastatin monotherapy by lipid-lowering efficacy, but both regimens made it possible to achieve the recommended reduction of low-density lipoprotein cholesterol level less than 2.6 mmol/l only in approximately 75 % of patients, and less than 1.8 mmol/l — only in 1/3 of patients. More significant decrease in serum triglyceride level was noted in patients treated with combined therapy (35 % A10/E10 vs 19.5 % A40, respectively; p < 0.05). A10/E10 combination has anti-inflammatory effect similar to that of A40 and advantages over A40 monotherapy in the effect on the endothelium function. A10/E10 application was associated with a trend to endothelial function improvement already after 7 days of treatment, and after 90 days of treatment increase in brachial artery diameter in this group of patients was significantly higher than in atorvastatin monotherapy (12.19 ± 1.09 A10/E10 vs 9.25 ± 1.16 A40; p < 0.05). Groups did not differ in the incidence of major complications in hospital and early posthospital periods of the disease." @default.
- W2891812619 created "2018-09-27" @default.
- W2891812619 creator A5000677608 @default.
- W2891812619 creator A5026721387 @default.
- W2891812619 creator A5028193672 @default.
- W2891812619 creator A5036345642 @default.
- W2891812619 creator A5086945524 @default.
- W2891812619 date "2014-01-01" @default.
- W2891812619 modified "2023-09-28" @default.
- W2891812619 title "Efficacy and Safety of Combined Lipid-Lowering Therapy with Ezetemibe and Atorvastatin in Patients with Acute Myocardial Infarction" @default.
- W2891812619 hasPublicationYear "2014" @default.
- W2891812619 type Work @default.
- W2891812619 sameAs 2891812619 @default.
- W2891812619 citedByCount "0" @default.
- W2891812619 crossrefType "journal-article" @default.
- W2891812619 hasAuthorship W2891812619A5000677608 @default.
- W2891812619 hasAuthorship W2891812619A5026721387 @default.
- W2891812619 hasAuthorship W2891812619A5028193672 @default.
- W2891812619 hasAuthorship W2891812619A5036345642 @default.
- W2891812619 hasAuthorship W2891812619A5086945524 @default.
- W2891812619 hasConcept C126322002 @default.
- W2891812619 hasConcept C164705383 @default.
- W2891812619 hasConcept C2776839432 @default.
- W2891812619 hasConcept C2776999253 @default.
- W2891812619 hasConcept C2777482532 @default.
- W2891812619 hasConcept C2778163477 @default.
- W2891812619 hasConcept C2778657065 @default.
- W2891812619 hasConcept C2778913445 @default.
- W2891812619 hasConcept C500558357 @default.
- W2891812619 hasConcept C71924100 @default.
- W2891812619 hasConcept C90924648 @default.
- W2891812619 hasConceptScore W2891812619C126322002 @default.
- W2891812619 hasConceptScore W2891812619C164705383 @default.
- W2891812619 hasConceptScore W2891812619C2776839432 @default.
- W2891812619 hasConceptScore W2891812619C2776999253 @default.
- W2891812619 hasConceptScore W2891812619C2777482532 @default.
- W2891812619 hasConceptScore W2891812619C2778163477 @default.
- W2891812619 hasConceptScore W2891812619C2778657065 @default.
- W2891812619 hasConceptScore W2891812619C2778913445 @default.
- W2891812619 hasConceptScore W2891812619C500558357 @default.
- W2891812619 hasConceptScore W2891812619C71924100 @default.
- W2891812619 hasConceptScore W2891812619C90924648 @default.
- W2891812619 hasOpenAccess W2891812619 @default.
- W2891812619 hasRelatedWork W1394974 @default.
- W2891812619 hasRelatedWork W1996129469 @default.
- W2891812619 hasRelatedWork W2064821745 @default.
- W2891812619 hasRelatedWork W2074207405 @default.
- W2891812619 hasRelatedWork W2082559134 @default.
- W2891812619 hasRelatedWork W2274273731 @default.
- W2891812619 hasRelatedWork W2352357141 @default.
- W2891812619 hasRelatedWork W2353146178 @default.
- W2891812619 hasRelatedWork W2357647624 @default.
- W2891812619 hasRelatedWork W2364195378 @default.
- W2891812619 hasRelatedWork W2384064605 @default.
- W2891812619 hasRelatedWork W2384885205 @default.
- W2891812619 hasRelatedWork W2399216047 @default.
- W2891812619 hasRelatedWork W2410049808 @default.
- W2891812619 hasRelatedWork W2415291601 @default.
- W2891812619 hasRelatedWork W2606701238 @default.
- W2891812619 hasRelatedWork W3046195923 @default.
- W2891812619 hasRelatedWork W3155692460 @default.
- W2891812619 hasRelatedWork W58784264 @default.
- W2891812619 hasRelatedWork W2188374185 @default.
- W2891812619 isParatext "false" @default.
- W2891812619 isRetracted "false" @default.
- W2891812619 magId "2891812619" @default.
- W2891812619 workType "article" @default.