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- W2891815450 abstract "e19035 Background: HSTL is a very rare neoplasm accounting for less than one percent of non- Hodgkin lymphomas. The most common presentation of the patient with HSTL is marked hepatosplenomegaly and thrombocytopenia without lymphadenopathy. We performed SEER data analysis for the patients with HSTL to investigate the socio-economic factors and survival outcomes for this rare disease. Methods: Data from 92 adult patients registered in the SEER data with diagnosis of HSTL, between year 1998-2012 and follow up through 2013 were analyzed. Impact of patient demographics (sex, age, and race, year of diagnosis, family income, education, unemployment) and treatment characteristics (delivery of radiotherapy and tumor directed surgery) on survival were evaluated via univariate analysis. Results: The mean age of diagnosis 40.4 ± 18 years (see table). The education, income and employment are zip code level based on 2000 census data. The annual income is cost of living adjusted median family income. The education is the percentage of people in patient’s zip code with college education. The median survival was 13 months. Out of the factors analyzed only surgery and radiation affected survival. The median survival for the patient who got tumor specific surgery was 20 months , compared to 8 months for those who did not get tumor specific surgery(p = 0.04). Conclusions: HSTL is more common in younger population with majority of patient less than 64 years of age. Also, it is more common in males. Age, sex, race, income, employment, education and year of diagnosis do not affect survival. Unfortunately, SEER database does not have details about chemotherapy or bone marrow transplant. Previous literature in form of case reports and case series has suggested splenectomy for management of HSTL. Our data suggest that pts who underwent tumor specific surgery had improved outcomes. [Table: see text]" @default.
- W2891815450 created "2018-09-27" @default.
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- W2891815450 date "2017-05-20" @default.
- W2891815450 modified "2023-09-27" @default.
- W2891815450 title "Hepatosplenic T-cell lymphoma (HSTL): A SEER data analysis." @default.
- W2891815450 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.e19035" @default.
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