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• W2891817334 abstract "The purpose of this study was to analyze the effects of hypoxia-inducible factor (HIF) stabilizers on anemia in non-dialysis-dependent (NDD) and dialysis-dependent (DD) chronic kidney disease (CKD) patients.Published studies were extracted from PubMed, China Biological Medicine Database (CBM), Wanfang database, and Cochrane Library on March 10, 2018, and relevant studies were pooled and included in a meta-analysis. Data on hemoglobin (Hb), ferritin, and hepcidin levels, total iron-binding capacity (TIBC), and incidence of adverse events (AEs) were extracted and pooled using Review Manager Version 5.3.Data from nine selected studies were extracted. Meta-analysis of the included studies showed that HIF stabilizers reduced ferritin and hepcidin levels and increased Hb level and TIBC in NDD-CKD patients. However, HIF stabilizers only increased TIBC, and did not affect ferritin, hepcidin, and Hb levels in DD-CKD patients. Furthermore, no notable differences in AEs and severe AEs between NDD-CKD and DD-CKD patients were detected.HIF stabilizers are effective for the treatment of anemia in NDD-CKD patients and safe for short-term use." @default.
• W2891817334 created "2018-09-27" @default.
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• W2891817334 date "2018-09-01" @default.
• W2891817334 modified "2023-09-24" @default.
• W2891817334 title "The role of hypoxia-inducible factor stabilizers in the treatment of anemia in patients with chronic kidney disease" @default.
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• W2891817334 doi "https://doi.org/10.2147/dddt.s175887" @default.
• W2891817334 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6151102" @default.
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