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• W2891817517 abstract "There are multiple copies of mitochondrial DNA (mtDNA) present in each cell type, and they are strictly regulated in a cell-specific manner by a group of nuclear-encoded mtDNA-specific replication factors. This strict regulation of mtDNA copy number is mediated by cell-specific DNA methylation of these replication factors. Glioblastoma multiforme, HSR-GBM1, cells are hyper-methylated and maintain low mtDNA copy number to support their tumorigenic status. We have previously shown that when HSR-GBM1 cells with 50% of their original mtDNA content were inoculated into mice, tumours grew more aggressively than non-depleted cells. However, when the cells possessed only 3% and 0.2% of their original mtDNA content, tumour formation was less frequent and the initiation of tumorigenesis was significantly delayed. Importantly, the process of tumorigenesis was dependent on mtDNA copy number being restored to pre-depletion levels. By performing whole genome MeDIP-Seq and RNA-Seq on tumours generated from cells possessing 100%, 50%, 0.3% and 0.2% of their original mtDNA content, we determined that restoration of mtDNA copy number caused significant changes to both the nuclear methylome and its transcriptome for each tumour type. The affected genes were specifically associated with gene networks and pathways involving behaviour, nervous system development, cell differentiation and regulation of transcription and cellular processes. The mtDNA-specific replication factors were also modulated. Our results highlight the bidirectional control of the nuclear and mitochondrial genomes through modulation of DNA methylation to control mtDNA copy number, which, in turn, modulates nuclear gene expression during tumorigenesis." @default.
• W2891817517 created "2018-09-27" @default.
• W2891817517 creator A5062672772 @default.
• W2891817517 creator A5074531047 @default.
• W2891817517 date "2018-09-12" @default.
• W2891817517 modified "2023-10-16" @default.
• W2891817517 title "Modulation of mitochondrial DNA copy number in a model of glioblastoma induces changes to DNA methylation and gene expression of the nuclear genome in tumours" @default.
• W2891817517 cites W1605945811 @default.
• W2891817517 cites W1801560648 @default.
• W2891817517 cites W1887760836 @default.
• W2891817517 cites W1960148369 @default.
• W2891817517 cites W1964767412 @default.
• W2891817517 cites W1970060454 @default.
• W2891817517 cites W1970857726 @default.
• W2891817517 cites W1971674000 @default.
• W2891817517 cites W1978422652 @default.
• W2891817517 cites W1988657398 @default.
• W2891817517 cites W1988756388 @default.
• W2891817517 cites W1988876420 @default.
• W2891817517 cites W1989925906 @default.
• W2891817517 cites W1993605227 @default.
• W2891817517 cites W1996052541 @default.
• W2891817517 cites W2001076497 @default.
• W2891817517 cites W2011747578 @default.
• W2891817517 cites W2013304964 @default.
• W2891817517 cites W2016923091 @default.
• W2891817517 cites W2019195029 @default.
• W2891817517 cites W2026050615 @default.
• W2891817517 cites W2026243411 @default.
• W2891817517 cites W2030637794 @default.
• W2891817517 cites W2036791811 @default.
• W2891817517 cites W2049415878 @default.
• W2891817517 cites W2051125954 @default.
• W2891817517 cites W2055986128 @default.
• W2891817517 cites W2068134440 @default.
• W2891817517 cites W2075204347 @default.
• W2891817517 cites W2077517552 @default.
• W2891817517 cites W2078972833 @default.
• W2891817517 cites W2080740457 @default.
• W2891817517 cites W2081360068 @default.
• W2891817517 cites W2090341757 @default.
• W2891817517 cites W2099343472 @default.
• W2891817517 cites W2101259235 @default.
• W2891817517 cites W2102619694 @default.
• W2891817517 cites W2103441770 @default.
• W2891817517 cites W2107883924 @default.
• W2891817517 cites W2109291482 @default.
• W2891817517 cites W2112305736 @default.
• W2891817517 cites W2115387230 @default.
• W2891817517 cites W2118983368 @default.
• W2891817517 cites W2124078079 @default.
• W2891817517 cites W2126817554 @default.
• W2891817517 cites W2129842345 @default.
• W2891817517 cites W2131187320 @default.
• W2891817517 cites W2134066544 @default.
• W2891817517 cites W2134728059 @default.
• W2891817517 cites W2136430672 @default.
• W2891817517 cites W2136888738 @default.
• W2891817517 cites W2145750252 @default.
• W2891817517 cites W2147734470 @default.
• W2891817517 cites W2152467392 @default.
• W2891817517 cites W2156295197 @default.
• W2891817517 cites W2158030172 @default.
• W2891817517 cites W2158088166 @default.
• W2891817517 cites W2163176001 @default.
• W2891817517 cites W2164813466 @default.
• W2891817517 cites W2170818431 @default.
• W2891817517 cites W2170830174 @default.
• W2891817517 cites W2176574121 @default.
• W2891817517 cites W2247766769 @default.
• W2891817517 cites W2266716830 @default.
• W2891817517 cites W2281867871 @default.
• W2891817517 cites W2314664365 @default.
• W2891817517 cites W2342891481 @default.
• W2891817517 cites W2405688533 @default.
• W2891817517 cites W2485678552 @default.
• W2891817517 cites W2507387671 @default.
• W2891817517 cites W2524175750 @default.
• W2891817517 cites W2559466477 @default.
• W2891817517 cites W2588488505 @default.
• W2891817517 cites W2620446315 @default.
• W2891817517 cites W2756196902 @default.
• W2891817517 cites W2766405334 @default.
• W2891817517 cites W2769101421 @default.
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• W2891817517 doi "https://doi.org/10.1186/s13072-018-0223-z" @default.
• W2891817517 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6136172" @default.
• W2891817517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30208958" @default.
• W2891817517 hasPublicationYear "2018" @default.
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