FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891820530> ?p ?o ?g. }

• W2891820530 endingPage "A0070" @default.
• W2891820530 startingPage "A0070" @default.
• W2891820530 abstract "Oligonucleotide-based therapeutics such as antisense oligonucleotides, small interfering RNAs (siRNAs), decoy and aptamer have been extensively developed. To investigate the pharmacokinetics of oligonucleotide therapeutics, it is common to label a radioisotope in a nucleic acid and visualize it. However, if the labeled terminal nucleotide is decomposed by a nuclease in vivo, only the labeled nucleotide is detected, and it is impossible to observe the nucleic acid exhibiting the drug effect. The distribution of biomolecules, such as phospholipids, proteins, and glycolipids, can be obtained and visualized without labeling using matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS). MALDI-IMS is also used in pharmacokinetic analysis to visualize a parent drug and its metabolites simultaneously. In this study, we reported a methodology for oligonucleotides analysis by MALDI-IMS. When phosphorothioate antisense oligonucleotide was administered into the eyeball of rats, it reached the retina after 30 min without undergoing decomposition by nucleases." @default.
• W2891820530 created "2018-09-27" @default.
• W2891820530 creator A5000457572 @default.
• W2891820530 creator A5007914982 @default.
• W2891820530 date "2018-09-11" @default.
• W2891820530 modified "2023-10-12" @default.
• W2891820530 title "Distribution of Antisense Oligonucleotides in Rat Eyeballs Using MALDI Imaging Mass Spectrometry" @default.
• W2891820530 cites W1611419331 @default.
• W2891820530 cites W1871736812 @default.
• W2891820530 cites W1965007922 @default.
• W2891820530 cites W1968949098 @default.
• W2891820530 cites W1971597849 @default.
• W2891820530 cites W2016313425 @default.
• W2891820530 cites W2033278243 @default.
• W2891820530 cites W2039121911 @default.
• W2891820530 cites W2047898183 @default.
• W2891820530 cites W2051010056 @default.
• W2891820530 cites W2059254076 @default.
• W2891820530 cites W2071598883 @default.
• W2891820530 cites W2113117576 @default.
• W2891820530 cites W2115450619 @default.
• W2891820530 cites W2122685117 @default.
• W2891820530 cites W2123173680 @default.
• W2891820530 cites W2132289754 @default.
• W2891820530 cites W2148320915 @default.
• W2891820530 cites W2152083346 @default.
• W2891820530 cites W2165553407 @default.
• W2891820530 cites W2500377063 @default.
• W2891820530 cites W2560666578 @default.
• W2891820530 cites W2600519390 @default.
• W2891820530 cites W2664012875 @default.
• W2891820530 cites W2746311786 @default.
• W2891820530 cites W2785220350 @default.
• W2891820530 cites W2785883179 @default.
• W2891820530 cites W2790635169 @default.
• W2891820530 cites W2792292549 @default.
• W2891820530 cites W2795531081 @default.
• W2891820530 cites W2797978148 @default.
• W2891820530 cites W2801424838 @default.
• W2891820530 cites W2801513916 @default.
• W2891820530 cites W2801654755 @default.
• W2891820530 cites W2803981458 @default.
• W2891820530 cites W2952510860 @default.
• W2891820530 doi "https://doi.org/10.5702/massspectrometry.a0070" @default.
• W2891820530 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6131115" @default.
• W2891820530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30214850" @default.
• W2891820530 hasPublicationYear "2018" @default.
• W2891820530 type Work @default.
• W2891820530 sameAs 2891820530 @default.
• W2891820530 citedByCount "15" @default.
• W2891820530 countsByYear W28918205302019 @default.
• W2891820530 countsByYear W28918205302020 @default.
• W2891820530 countsByYear W28918205302021 @default.
• W2891820530 countsByYear W28918205302022 @default.
• W2891820530 countsByYear W28918205302023 @default.
• W2891820530 crossrefType "journal-article" @default.
• W2891820530 hasAuthorship W2891820530A5000457572 @default.
• W2891820530 hasAuthorship W2891820530A5007914982 @default.
• W2891820530 hasBestOaLocation W28918205301 @default.
• W2891820530 hasConcept C104317684 @default.
• W2891820530 hasConcept C128972844 @default.
• W2891820530 hasConcept C129312508 @default.
• W2891820530 hasConcept C150394285 @default.
• W2891820530 hasConcept C153911025 @default.
• W2891820530 hasConcept C162356407 @default.
• W2891820530 hasConcept C162711632 @default.
• W2891820530 hasConcept C178790620 @default.
• W2891820530 hasConcept C185592680 @default.
• W2891820530 hasConcept C24066741 @default.
• W2891820530 hasConcept C24107716 @default.
• W2891820530 hasConcept C2777271071 @default.
• W2891820530 hasConcept C43617362 @default.
• W2891820530 hasConcept C512185932 @default.
• W2891820530 hasConcept C552990157 @default.
• W2891820530 hasConcept C55493867 @default.
• W2891820530 hasConcept C67705224 @default.
• W2891820530 hasConcept C75280812 @default.
• W2891820530 hasConcept C86803240 @default.
• W2891820530 hasConceptScore W2891820530C104317684 @default.
• W2891820530 hasConceptScore W2891820530C128972844 @default.
• W2891820530 hasConceptScore W2891820530C129312508 @default.
• W2891820530 hasConceptScore W2891820530C150394285 @default.
• W2891820530 hasConceptScore W2891820530C153911025 @default.
• W2891820530 hasConceptScore W2891820530C162356407 @default.
• W2891820530 hasConceptScore W2891820530C162711632 @default.
• W2891820530 hasConceptScore W2891820530C178790620 @default.
• W2891820530 hasConceptScore W2891820530C185592680 @default.
• W2891820530 hasConceptScore W2891820530C24066741 @default.
• W2891820530 hasConceptScore W2891820530C24107716 @default.
• W2891820530 hasConceptScore W2891820530C2777271071 @default.
• W2891820530 hasConceptScore W2891820530C43617362 @default.
• W2891820530 hasConceptScore W2891820530C512185932 @default.
• W2891820530 hasConceptScore W2891820530C552990157 @default.
• W2891820530 hasConceptScore W2891820530C55493867 @default.
• W2891820530 hasConceptScore W2891820530C67705224 @default.
• W2891820530 hasConceptScore W2891820530C75280812 @default.
• W2891820530 hasConceptScore W2891820530C86803240 @default.
• W2891820530 hasIssue "1" @default.

• next