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- W2891821120 endingPage "1094" @default.
- W2891821120 startingPage "1084" @default.
- W2891821120 abstract "Teriparatide (TPTD) and abaloparatide (ABL) are the only osteoanabolic drugs available, at this time, for treatment of osteoporosis. TPTD is a 34‐amino acid fragment that is identical in its primary sequence to the 34 amino acids of full‐length human parathyroid hormone [hPTH(1‐84)]. ABL is identical to parathyroid hormone‐related peptide (PTHrP) through the first 22 residues with significantly different amino acids inserted thereafter, between residues 22 and 34. The osteoanabolic actions of PTH are due directly to its effects on cells of the osteoblast lineage and indirectly by stimulating IGF‐I synthesis and suppressing sclerostin and associated enhancement of Wnt signalling. Both TPTD and ABL are ligands that bind to and activate the PTH receptor type 1 (PTHR1) receptor but they appear to do so differently: ABL favours the transient, more anabolic configuration of the receptor. Both TPTD and ABL reduce the risk of vertebral fractures and non‐vertebral fractures. Both drugs are administered for a maximum of 24 months, and should be followed by an antiresorptive agent to maintain gains in bone mineral density (BMD). Romosozumab, a monoclonal antibody that binds to and inhibits sclerostin, appears to have dual actions by stimulating bone formation and reducing bone resorption. In the pivotal clinical trial, romosozumab, administered as a 210 mg monthly subcutaneous dose, significantly reduced new vertebral fractures and in a subsequent study reduced both vertebral and non‐vertebral fractures." @default.
- W2891821120 created "2018-09-27" @default.
- W2891821120 creator A5013126573 @default.
- W2891821120 creator A5030690224 @default.
- W2891821120 date "2019-04-03" @default.
- W2891821120 modified "2023-10-14" @default.
- W2891821120 title "Osteoanabolic and dual action drugs" @default.
- W2891821120 cites W1554395215 @default.
- W2891821120 cites W1911703092 @default.
- W2891821120 cites W1947259556 @default.
- W2891821120 cites W1965296596 @default.
- W2891821120 cites W1972828099 @default.
- W2891821120 cites W1979462438 @default.
- W2891821120 cites W1981602322 @default.
- W2891821120 cites W1982398983 @default.
- W2891821120 cites W1988149299 @default.
- W2891821120 cites W1988801456 @default.
- W2891821120 cites W1989400609 @default.
- W2891821120 cites W1989880575 @default.
- W2891821120 cites W1992310701 @default.
- W2891821120 cites W1998642915 @default.
- W2891821120 cites W2015350578 @default.
- W2891821120 cites W2016251348 @default.
- W2891821120 cites W2028910660 @default.
- W2891821120 cites W2030192805 @default.
- W2891821120 cites W2032208190 @default.
- W2891821120 cites W2032850866 @default.
- W2891821120 cites W2040271062 @default.
- W2891821120 cites W2041050634 @default.
- W2891821120 cites W2041578222 @default.
- W2891821120 cites W2041598849 @default.
- W2891821120 cites W2042007405 @default.
- W2891821120 cites W2043450395 @default.
- W2891821120 cites W2050078279 @default.
- W2891821120 cites W2055344817 @default.
- W2891821120 cites W2062496249 @default.
- W2891821120 cites W2064390254 @default.
- W2891821120 cites W2073790420 @default.
- W2891821120 cites W2075876977 @default.
- W2891821120 cites W2077419222 @default.
- W2891821120 cites W2078245594 @default.
- W2891821120 cites W2080818296 @default.
- W2891821120 cites W2082817154 @default.
- W2891821120 cites W2086937931 @default.
- W2891821120 cites W2096303371 @default.
- W2891821120 cites W2096627331 @default.
- W2891821120 cites W2099028287 @default.
- W2891821120 cites W2101680622 @default.
- W2891821120 cites W2102177673 @default.
- W2891821120 cites W2103502150 @default.
- W2891821120 cites W2108106130 @default.
- W2891821120 cites W2111048208 @default.
- W2891821120 cites W2112292482 @default.
- W2891821120 cites W2127985847 @default.
- W2891821120 cites W2136148821 @default.
- W2891821120 cites W2138829214 @default.
- W2891821120 cites W2146195922 @default.
- W2891821120 cites W2166468389 @default.
- W2891821120 cites W2176994106 @default.
- W2891821120 cites W2275985167 @default.
- W2891821120 cites W2285090680 @default.
- W2891821120 cites W2295122297 @default.
- W2891821120 cites W2331946330 @default.
- W2891821120 cites W2335178464 @default.
- W2891821120 cites W2344107695 @default.
- W2891821120 cites W2516614130 @default.
- W2891821120 cites W2518062514 @default.
- W2891821120 cites W2520995084 @default.
- W2891821120 cites W2533066994 @default.
- W2891821120 cites W2547154847 @default.
- W2891821120 cites W2560207284 @default.
- W2891821120 cites W2583623004 @default.
- W2891821120 cites W2604795974 @default.
- W2891821120 cites W2605454354 @default.
- W2891821120 cites W2611457288 @default.
- W2891821120 cites W2617811370 @default.
- W2891821120 cites W2619207470 @default.
- W2891821120 cites W2647480660 @default.
- W2891821120 cites W2728709142 @default.
- W2891821120 cites W2729776149 @default.
- W2891821120 cites W2738136796 @default.
- W2891821120 cites W2740502056 @default.
- W2891821120 cites W2754720807 @default.
- W2891821120 cites W2765684626 @default.
- W2891821120 cites W2767671304 @default.
- W2891821120 cites W2769260297 @default.
- W2891821120 cites W2771328536 @default.
- W2891821120 cites W2772492141 @default.
- W2891821120 cites W2775903390 @default.
- W2891821120 cites W2791964189 @default.
- W2891821120 cites W2792853877 @default.
- W2891821120 cites W2793982131 @default.
- W2891821120 cites W2801382541 @default.
- W2891821120 cites W2801463953 @default.
- W2891821120 cites W2801829254 @default.
- W2891821120 cites W2803459905 @default.
- W2891821120 cites W2806991693 @default.
- W2891821120 cites W2808994945 @default.