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• W2891822000 abstract "Platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) are promising tools for muscular-skeletal regeneration. However, increasing evidence has demonstrated controversial effects of PRP on the tissue regeneration. To obtain optimum PRP concentrations for MSC expansion and to accurately control osteogenic, adipocytic, and chondrogenic differentiation, MSCs were exposed to PRP alone or in combination with induction medium. We found that PRPs with the platelet concentration beyond 1500 × 109 pl/L were preferable to promote MSC proliferation. In addition, PRPs ranging from 200 × 109 to 3000 × 109 pl/L were capable of augmenting MSC osteogenesis, and PRP with 1500 × 109 pl/L was most effective for MSC osteogenic differentiation. Furthermore, PRPs in low platelet concentration range just slightly promoted MSC adipogenesis, and only when the platelet concentration was beyond 1800 × 109 pl/L, the promoted effects were evident. Moreover, PRP range from 1000 to 3000 × 109 pl/L significantly enhanced chondrogenesis of MSCs in the absence and presence of chondrogenic induction medium, and PRP with 2000 × 109 pl/L was more effective for MSC chondrogenesis. Furthermore, we explored the mechanisms of PRP-induced MSC differentiation, showing that the growth factors played a major role in this process while other unknown factors may also be involved in it. At last, we measured the levels of cytokines to learn that PRP treatment suppressed the secretion of interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α, but favored the production of IL-10 by MSCs. In summary, our findings demonstrated that PRPs with different concentrations of platelets exerted different effects on proliferation and differentiation of MSCs, which indicated that preparing appropriate PRPs may be a precise and efficient strategy for improving MSC-based tissue regeneration. In the current study, we screened the effects of different concentrations of platelet-rich plasma (PRP) on the mesenchymal stem cell (MSC) proliferation and differentiation. Our data demonstrated that concentrated PRP exerted different effects on cell proliferation and on the osteogenic, adipogenic, and chondrogenic differentiation of human bone marrow-derived MSCs. Meanwhile, we optimized PRP concentrations for each of these lineage differentiation and MSC expansion and, thus, suggested several promising clinical strategies for different kinds of diseases. These findings may help explain the controversial effects of PRP on MSCs and improve the progress in precise applications of PRP-based regenerative strategies." @default.
• W2891822000 created "2018-09-27" @default.
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• W2891822000 date "2019-03-01" @default.
• W2891822000 modified "2023-10-12" @default.
• W2891822000 title "Optimization of the Platelet-Rich Plasma Concentration for Mesenchymal Stem Cell Applications" @default.
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• W2891822000 doi "https://doi.org/10.1089/ten.tea.2018.0091" @default.
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