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• W2891822641 abstract "Natural or full-length hammerhead ribozymes are up to 1000-fold more active than their minimal counterparts that lack a complex tertiary interaction that pre-organizes and stabilizes the ribozyme active site, positioning RNA functional groups to facilitate acid-base catalysis. The recent discovery that a single tertiary contact (an AU Hoogsteen pair) between Stems I and II confers essentially all of the enhanced activity greatly simplifies our understanding of the structural requirements for hammerhead ribozyme activity. In contrast, the simplest mechanistic interpretations are challenged with the presentation of more complex alternatives. These alternatives are elucidated and critically analyzed in the context of several of the active hammerhead ribozyme structures now available." @default.
• W2891822641 created "2018-09-27" @default.
• W2891822641 creator A5037878942 @default.
• W2891822641 creator A5090007432 @default.
• W2891822641 date "2018-01-01" @default.
• W2891822641 modified "2023-09-23" @default.
• W2891822641 title "Structural Simplicity and Mechanistic Complexity in the Hammerhead Ribozyme" @default.
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• W2891822641 doi "https://doi.org/10.1016/bs.pmbts.2018.07.006" @default.
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