Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891823402> ?p ?o ?g. }
- W2891823402 endingPage "1664" @default.
- W2891823402 startingPage "1664" @default.
- W2891823402 abstract "Calcium silicate-based cement has garnered huge interest in recent years, due to its versatility and potential in mass fabrication of a variety of bioceramics. For this study, the main objective was to fabricate functionalized calcium silicate (CS) powder integrated with a simple bio-inspired surface modification using polydopamine (PDA), to regulate cellular behaviors such as cellular adhesion, and subsequently cell differentiation and proliferation. For this study, scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) techniques were used to analyze the chemical compositions and observe the surface characteristics of our PDA coated CS cements. Such modifications were found to enhance Wharton Jelly’s mesenchymal stem cells (WJMSC) in various ways. Firstly, PDA-coated CS cements were found to significantly enhance cell adhesion with higher expressions of cell adhesion markers, such as focal adhesion kinase and integrins. This was further supported by morphology analysis of the cells. This enhanced cell adhesion, in turn, led to significantly higher secretion of extracellular matrix (ECM) proteins, such as collagen I and fibronectin, which directly promoted cell attachments and proliferation. In our osteogenesis assays, it was found that secretion and expression of osteogenesis related genes and proteins were significantly higher and were dependent on the PDA content. Therefore, these results demonstrated that such simple bio-inspired modification techniques of synthetic degradable CS cements can be applied as a future modification, to modify and convert inert surfaces of synthetic bone grafts to enhance and modulate the cell behaviors of WJMSCs. This in turn can be used as a potential alternative for further bioengineering research." @default.
- W2891823402 created "2018-09-27" @default.
- W2891823402 creator A5002525179 @default.
- W2891823402 creator A5017019111 @default.
- W2891823402 creator A5036555849 @default.
- W2891823402 creator A5047242707 @default.
- W2891823402 creator A5047594634 @default.
- W2891823402 creator A5073582577 @default.
- W2891823402 creator A5088880740 @default.
- W2891823402 date "2018-09-09" @default.
- W2891823402 modified "2023-10-03" @default.
- W2891823402 title "Surface Modification of Calcium Silicate via Mussel-Inspired Polydopamine and Effective Adsorption of Extracellular Matrix to Promote Osteogenesis Differentiation for Bone Tissue Engineering" @default.
- W2891823402 cites W1489372568 @default.
- W2891823402 cites W1498378898 @default.
- W2891823402 cites W1533693006 @default.
- W2891823402 cites W1770785006 @default.
- W2891823402 cites W1843989933 @default.
- W2891823402 cites W1846925491 @default.
- W2891823402 cites W1946269683 @default.
- W2891823402 cites W1990934483 @default.
- W2891823402 cites W1994369247 @default.
- W2891823402 cites W1994792869 @default.
- W2891823402 cites W1996833161 @default.
- W2891823402 cites W2000620469 @default.
- W2891823402 cites W2013647879 @default.
- W2891823402 cites W2036669971 @default.
- W2891823402 cites W2046132185 @default.
- W2891823402 cites W2057008414 @default.
- W2891823402 cites W2061310848 @default.
- W2891823402 cites W2063261010 @default.
- W2891823402 cites W2064371327 @default.
- W2891823402 cites W2069687878 @default.
- W2891823402 cites W2089364101 @default.
- W2891823402 cites W2090044461 @default.
- W2891823402 cites W2090380484 @default.
- W2891823402 cites W2135870432 @default.
- W2891823402 cites W2144494087 @default.
- W2891823402 cites W2171179595 @default.
- W2891823402 cites W2180130396 @default.
- W2891823402 cites W2250943496 @default.
- W2891823402 cites W2283335125 @default.
- W2891823402 cites W2315963230 @default.
- W2891823402 cites W2322562148 @default.
- W2891823402 cites W2323258862 @default.
- W2891823402 cites W2323647379 @default.
- W2891823402 cites W2342776507 @default.
- W2891823402 cites W2417855748 @default.
- W2891823402 cites W2423147219 @default.
- W2891823402 cites W2514623828 @default.
- W2891823402 cites W2517048036 @default.
- W2891823402 cites W2565929961 @default.
- W2891823402 cites W2566917612 @default.
- W2891823402 cites W2570590878 @default.
- W2891823402 cites W2605072510 @default.
- W2891823402 cites W2605587776 @default.
- W2891823402 cites W2610260527 @default.
- W2891823402 cites W2744451519 @default.
- W2891823402 cites W2745790665 @default.
- W2891823402 cites W2761641864 @default.
- W2891823402 cites W2777625939 @default.
- W2891823402 cites W2790983071 @default.
- W2891823402 cites W2793314973 @default.
- W2891823402 cites W2800035913 @default.
- W2891823402 cites W2805199677 @default.
- W2891823402 cites W2886696581 @default.
- W2891823402 cites W903904613 @default.
- W2891823402 doi "https://doi.org/10.3390/ma11091664" @default.
- W2891823402 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6165256" @default.
- W2891823402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30205589" @default.
- W2891823402 hasPublicationYear "2018" @default.
- W2891823402 type Work @default.
- W2891823402 sameAs 2891823402 @default.
- W2891823402 citedByCount "25" @default.
- W2891823402 countsByYear W28918234022019 @default.
- W2891823402 countsByYear W28918234022020 @default.
- W2891823402 countsByYear W28918234022021 @default.
- W2891823402 countsByYear W28918234022022 @default.
- W2891823402 countsByYear W28918234022023 @default.
- W2891823402 crossrefType "journal-article" @default.
- W2891823402 hasAuthorship W2891823402A5002525179 @default.
- W2891823402 hasAuthorship W2891823402A5017019111 @default.
- W2891823402 hasAuthorship W2891823402A5036555849 @default.
- W2891823402 hasAuthorship W2891823402A5047242707 @default.
- W2891823402 hasAuthorship W2891823402A5047594634 @default.
- W2891823402 hasAuthorship W2891823402A5073582577 @default.
- W2891823402 hasAuthorship W2891823402A5088880740 @default.
- W2891823402 hasBestOaLocation W28918234021 @default.
- W2891823402 hasConcept C115537861 @default.
- W2891823402 hasConcept C12554922 @default.
- W2891823402 hasConcept C136229726 @default.
- W2891823402 hasConcept C147789679 @default.
- W2891823402 hasConcept C1491633281 @default.
- W2891823402 hasConcept C150394285 @default.
- W2891823402 hasConcept C159985019 @default.
- W2891823402 hasConcept C171250308 @default.
- W2891823402 hasConcept C178790620 @default.
- W2891823402 hasConcept C185592680 @default.
- W2891823402 hasConcept C189165786 @default.