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- W2891828314 abstract "Expression of the Q5k gene was examined by northern blot analysis and polymerase chain reaction (PCR) in the AKR mouse and various cell lines, each of the H-2k haplotype. Our results show that Q5k mRNA is present during the whole postimplantational development of the AKR embryo/fetus (gestation day 6 to 15). In the juvenile mouse (week 2 to 4) transcription of the Q5k gene persisted in all organs examined. In contrast, in the adult animal expression of the Q5k gene was limited to the thymus and uterus of the pregnant mouse. Upon malignant transformation, the amount of Q5k-specific mRNA increased dramatically in thymus and could also be observed in the spleen of thymoma bearing animals. Expression of the Q5k gene was also detectable in several transformed mouse cell lines. Mitogen stimulation or treatment with cytokines induced Q5k expression in primary spleen cell cultures. A possible explanation for the tissue-restricted expression in the adult AKR mouse is discussed." @default.
- W2891828314 created "2018-09-27" @default.
- W2891828314 creator A5013132392 @default.
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- W2891828314 creator A5061684537 @default.
- W2891828314 creator A5074484140 @default.
- W2891828314 creator A5089500666 @default.
- W2891828314 date "1991-07-01" @default.
- W2891828314 modified "2023-09-23" @default.
- W2891828314 title "Developmental and tissue-specific expression of the Q5 k gene" @default.
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- W2891828314 doi "https://doi.org/10.1007/bf00212309" @default.
- W2891828314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1713191" @default.
- W2891828314 hasPublicationYear "1991" @default.
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