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• W2891830118 startingPage "869" @default.
• W2891830118 abstract "Introduction: The main regulatory subunits of Class IA phosphatidylinositol 3-kinase (PI3K), p85α and p85β, initiate diverse cellular activities independent of binding to the catalytic subunit p110. Several of these signaling processes directly or indirectly contribute to a regulation of PI3K and could become targets for therapeutic efforts.Areas covered: This review will highlight two general areas of p85 activity: (1) direct interaction with regulatory proteins and with determinants of the cytoskeleton, and (2) a genetic analysis by deletion and domain switches identifying new functions for p85 domains.Expert Opinion: Isoform-specific activities of regulatory subunits have long been at the periphery of the PI3K field. Our understanding of these unique functions of the regulatory subunits is fragmentary and raises many important questions. At this time, there is insufficient information to translate this knowledge into the clinic, but some tempting targets have emerged that could move the field forward with the help of novel technologies in drug design and identification." @default.
• W2891830118 created "2018-09-27" @default.
• W2891830118 creator A5001267309 @default.
• W2891830118 creator A5010679975 @default.
• W2891830118 creator A5030737227 @default.
• W2891830118 date "2018-09-24" @default.
• W2891830118 modified "2023-10-12" @default.
• W2891830118 title "Isoform-specific activities of the regulatory subunits of phosphatidylinositol 3-kinases – potentially novel therapeutic targets" @default.
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• W2891830118 doi "https://doi.org/10.1080/14728222.2018.1522302" @default.
• W2891830118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6197473" @default.
• W2891830118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30205700" @default.
• W2891830118 hasPublicationYear "2018" @default.
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