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- W2891830541 abstract "• Allostatic stress represents a challenge to emotion-related brain circuit regulatory mechanisms. • Stress alters function in all three stages of the addiction cycle. • Stress contributes to dysregulation of incentive salience/habits, negative emotional states, and executive function. • Stress-induced neurocircuitry dysregulation is involved in the transition to pathophysiology. Allostasis, or stability through change, has most often been linked with challenges to homeostasis, in which repeated challenges or stressors produce sufficient allostatic load to generate an allostatic state that can ultimately lead to a disease state. The present review argues that the impact of stress on drug addiction fits with an allostatic model and represents a challenge to brain circuit regulatory mechanisms that underlie the emotional state of the animal. The central thesis is that stress leads to changes in corticotropin-releasing factor in the brain that impact addiction. Stress is further argued to impact all three stages of the addiction cycle— binge/intoxication , withdrawal/negative affect , and preoccupation/anticipation— exposing the animal to an emotional allostatic load and allostatic state that forms the growing motivational pathology of addiction. Viewing addiction as an allostatic mechanism provides key insights into the ways in which dysregulated neurocircuitry that is involved in basic motivational systems can transition to pathophysiology." @default.
- W2891830541 created "2018-09-27" @default.
- W2891830541 creator A5028175101 @default.
- W2891830541 creator A5075246876 @default.
- W2891830541 date "2019-11-01" @default.
- W2891830541 modified "2023-10-16" @default.
- W2891830541 title "Addiction and stress: An allostatic view" @default.
- W2891830541 cites W1518117902 @default.
- W2891830541 cites W1594183867 @default.
- W2891830541 cites W1659240124 @default.
- W2891830541 cites W1730875209 @default.
- W2891830541 cites W1771301420 @default.
- W2891830541 cites W1789705209 @default.
- W2891830541 cites W1841579139 @default.
- W2891830541 cites W1891678001 @default.
- W2891830541 cites W1910403263 @default.
- W2891830541 cites W1966014889 @default.
- W2891830541 cites W1967265097 @default.
- W2891830541 cites W1967595526 @default.
- W2891830541 cites W1968346138 @default.
- W2891830541 cites W1971014321 @default.
- W2891830541 cites W1972408435 @default.
- W2891830541 cites W1972762203 @default.
- W2891830541 cites W1974467694 @default.
- W2891830541 cites W1975999231 @default.
- W2891830541 cites W1977102147 @default.
- W2891830541 cites W1977137145 @default.
- W2891830541 cites W1977216968 @default.
- W2891830541 cites W1978762354 @default.
- W2891830541 cites W1980637329 @default.
- W2891830541 cites W1981727048 @default.
- W2891830541 cites W1983708315 @default.
- W2891830541 cites W1984109440 @default.
- W2891830541 cites W1984631396 @default.
- W2891830541 cites W1985427696 @default.
- W2891830541 cites W1986079135 @default.
- W2891830541 cites W1988182239 @default.
- W2891830541 cites W1988650551 @default.
- W2891830541 cites W1989416066 @default.
- W2891830541 cites W1991055198 @default.
- W2891830541 cites W1991105264 @default.
- W2891830541 cites W1991666427 @default.
- W2891830541 cites W1991882455 @default.
- W2891830541 cites W1992221884 @default.
- W2891830541 cites W1994725667 @default.
- W2891830541 cites W1994867341 @default.
- W2891830541 cites W1995972738 @default.
- W2891830541 cites W1996108093 @default.
- W2891830541 cites W1996880759 @default.
- W2891830541 cites W2004987149 @default.
- W2891830541 cites W2005214102 @default.
- W2891830541 cites W2005774467 @default.
- W2891830541 cites W2007376383 @default.
- W2891830541 cites W2007791604 @default.
- W2891830541 cites W2008263329 @default.
- W2891830541 cites W2009073501 @default.
- W2891830541 cites W2010158373 @default.
- W2891830541 cites W2010455608 @default.
- W2891830541 cites W2010555262 @default.
- W2891830541 cites W2011682979 @default.
- W2891830541 cites W2015559939 @default.
- W2891830541 cites W2017889444 @default.
- W2891830541 cites W2018119432 @default.
- W2891830541 cites W2018514933 @default.
- W2891830541 cites W2019930104 @default.
- W2891830541 cites W2020065445 @default.
- W2891830541 cites W2020327987 @default.
- W2891830541 cites W2020969667 @default.
- W2891830541 cites W2023703027 @default.
- W2891830541 cites W2023872238 @default.
- W2891830541 cites W2025192622 @default.
- W2891830541 cites W2026803933 @default.
- W2891830541 cites W2031322724 @default.
- W2891830541 cites W2032643119 @default.
- W2891830541 cites W2033824845 @default.
- W2891830541 cites W2035768743 @default.
- W2891830541 cites W2036970657 @default.
- W2891830541 cites W2037249096 @default.
- W2891830541 cites W2037417281 @default.
- W2891830541 cites W2038120147 @default.
- W2891830541 cites W2038250999 @default.
- W2891830541 cites W2038357517 @default.
- W2891830541 cites W2038874217 @default.
- W2891830541 cites W2039389059 @default.
- W2891830541 cites W2042817255 @default.
- W2891830541 cites W2044676961 @default.
- W2891830541 cites W2046132702 @default.
- W2891830541 cites W2046986816 @default.
- W2891830541 cites W2047349915 @default.
- W2891830541 cites W2048199491 @default.
- W2891830541 cites W2049087748 @default.
- W2891830541 cites W2050301199 @default.
- W2891830541 cites W2050538748 @default.
- W2891830541 cites W2050642260 @default.
- W2891830541 cites W2050750919 @default.
- W2891830541 cites W2050857651 @default.
- W2891830541 cites W2053152793 @default.
- W2891830541 cites W2054684724 @default.