FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891835498> ?p ?o ?g. }

• W2891835498 endingPage "1214" @default.
• W2891835498 startingPage "1206" @default.
• W2891835498 abstract "Abstract On the basis of multiple experiments demonstrating that high resistance to stress is associated with long lifespan, it has been proposed that stress resistance is a key determinant of longevity. However, the extent to which high resistance to stress is necessary or sufficient for long life is currently unclear. In this work, we use a genetic approach to disrupt different stress response pathways and examine the resulting effect on the longevity of the long-lived insulin-like growth factor 1 (IGF1) receptor mutant daf-2. Although mutation of the heat shock factor gene hsf-1, deletion of sod genes, deletion of the p38 MAPK kinase gene pmk-1, or deletion of the transcription factor gene egl-27 all resulted in decreased resistance to at least one form of stress and decreased lifespan, the magnitude of change in stress resistance did not correspond to the magnitude of change in lifespan. In addition, we found that deletion of the glycerol-3-phosphate dehydrogenase genes gpdh-1 and gpdh-2 or deletion of the DAF-16 cofactor gene nhl-1 also results in decreased resistance to at least one form of stress but increases lifespan. Overall, our results suggest that while increased stress resistance is associated with longevity, stress resistance, and lifespan can be experimentally dissociated." @default.
• W2891835498 created "2018-09-27" @default.
• W2891835498 creator A5008030766 @default.
• W2891835498 creator A5014599700 @default.
• W2891835498 creator A5047648680 @default.
• W2891835498 creator A5081957662 @default.
• W2891835498 date "2018-09-21" @default.
• W2891835498 modified "2023-10-10" @default.
• W2891835498 title "Resistance to Stress Can Be Experimentally Dissociated From Longevity" @default.
• W2891835498 cites W1847809821 @default.
• W2891835498 cites W1877188956 @default.
• W2891835498 cites W1938310987 @default.
• W2891835498 cites W1964274784 @default.
• W2891835498 cites W1965588810 @default.
• W2891835498 cites W1966453007 @default.
• W2891835498 cites W1976028803 @default.
• W2891835498 cites W1976654687 @default.
• W2891835498 cites W1982660847 @default.
• W2891835498 cites W1985905314 @default.
• W2891835498 cites W1989323843 @default.
• W2891835498 cites W1996054899 @default.
• W2891835498 cites W1997052628 @default.
• W2891835498 cites W2004256161 @default.
• W2891835498 cites W2011912518 @default.
• W2891835498 cites W2023431124 @default.
• W2891835498 cites W2043287965 @default.
• W2891835498 cites W2046913124 @default.
• W2891835498 cites W2046989794 @default.
• W2891835498 cites W2049349831 @default.
• W2891835498 cites W2052570011 @default.
• W2891835498 cites W2061195953 @default.
• W2891835498 cites W2074783650 @default.
• W2891835498 cites W2089071989 @default.
• W2891835498 cites W2093935763 @default.
• W2891835498 cites W2099008186 @default.
• W2891835498 cites W2101861123 @default.
• W2891835498 cites W2104818214 @default.
• W2891835498 cites W2119146677 @default.
• W2891835498 cites W2121867223 @default.
• W2891835498 cites W2122727672 @default.
• W2891835498 cites W2123703699 @default.
• W2891835498 cites W214549959 @default.
• W2891835498 cites W2147251959 @default.
• W2891835498 cites W2151160060 @default.
• W2891835498 cites W2155914183 @default.
• W2891835498 cites W2156058796 @default.
• W2891835498 cites W2162232168 @default.
• W2891835498 cites W2166855962 @default.
• W2891835498 cites W2170138349 @default.
• W2891835498 cites W2407890715 @default.
• W2891835498 cites W2605260824 @default.
• W2891835498 cites W2744241832 @default.
• W2891835498 cites W60943716 @default.
• W2891835498 doi "https://doi.org/10.1093/gerona/gly213" @default.
• W2891835498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6625593" @default.
• W2891835498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30247515" @default.
• W2891835498 hasPublicationYear "2018" @default.
• W2891835498 type Work @default.
• W2891835498 sameAs 2891835498 @default.
• W2891835498 citedByCount "34" @default.
• W2891835498 countsByYear W28918354982019 @default.
• W2891835498 countsByYear W28918354982020 @default.
• W2891835498 countsByYear W28918354982021 @default.
• W2891835498 countsByYear W28918354982022 @default.
• W2891835498 countsByYear W28918354982023 @default.
• W2891835498 crossrefType "journal-article" @default.
• W2891835498 hasAuthorship W2891835498A5008030766 @default.
• W2891835498 hasAuthorship W2891835498A5014599700 @default.
• W2891835498 hasAuthorship W2891835498A5047648680 @default.
• W2891835498 hasAuthorship W2891835498A5081957662 @default.
• W2891835498 hasBestOaLocation W28918354981 @default.
• W2891835498 hasConcept C104317684 @default.
• W2891835498 hasConcept C143065580 @default.
• W2891835498 hasConcept C2776759703 @default.
• W2891835498 hasConcept C54355233 @default.
• W2891835498 hasConcept C86339819 @default.
• W2891835498 hasConcept C86803240 @default.
• W2891835498 hasConcept C95444343 @default.
• W2891835498 hasConceptScore W2891835498C104317684 @default.
• W2891835498 hasConceptScore W2891835498C143065580 @default.
• W2891835498 hasConceptScore W2891835498C2776759703 @default.
• W2891835498 hasConceptScore W2891835498C54355233 @default.
• W2891835498 hasConceptScore W2891835498C86339819 @default.
• W2891835498 hasConceptScore W2891835498C86803240 @default.
• W2891835498 hasConceptScore W2891835498C95444343 @default.
• W2891835498 hasFunder F4320332161 @default.
• W2891835498 hasFunder F4320337354 @default.
• W2891835498 hasIssue "8" @default.
• W2891835498 hasLocation W28918354981 @default.
• W2891835498 hasLocation W28918354982 @default.
• W2891835498 hasLocation W28918354983 @default.
• W2891835498 hasLocation W28918354984 @default.
• W2891835498 hasOpenAccess W2891835498 @default.
• W2891835498 hasPrimaryLocation W28918354981 @default.
• W2891835498 hasRelatedWork W1983725845 @default.
• W2891835498 hasRelatedWork W2009416280 @default.
• W2891835498 hasRelatedWork W2016097750 @default.
• W2891835498 hasRelatedWork W2101920100 @default.

• next