FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891836041> ?p ?o ?g. }

• W2891836041 endingPage "97" @default.
• W2891836041 startingPage "97" @default.
• W2891836041 abstract "The aim of this work is to study, in an in vitro head and neck squamous cell carcinomas model the anti-angiogenic and anti-migratory properties of self-assembled polymeric nanoparticles (NPs) with demonstrated selective anticancer activity. The NPs are based on α-tocopheryl succinate (α-TOS) encapsulated in the hydrophobic core of the NPs. We analyzed the effect of the newly synthetized α-TOS-loaded NPs in proliferating endothelial cells and hypopharynx carcinoma squamous cells and measured markers of angiogenesis, apoptosis and reactive oxygen species (ROS). α-TOS-loaded NPs suppressed angiogenesis by inducing accumulation of ROS and inducing apoptosis of proliferating endothelial cells. These NPs also decrease the number and quality of capillary-like tubes in an in vitro three-dimensional (3D) experiment, decrease the production of the pro-angiogenic vascular endothelial growth factor and down-regulate the expression of its receptor. The anti-migratory efficacy of α-TOS is corroborated in hypopharynx carcinoma cells by decreasing the secretion of matrix metalloproteases 2 and 9 (MMP-2 and MMP-9) and inhibiting cell migration. These results confirm that α-TOS-based NPs not only present anticancer properties, but also antiangiogenic properties, therefore making them promising candidates for multi-active combinatorial anticancer therapy." @default.
• W2891836041 created "2018-09-27" @default.
• W2891836041 creator A5018438022 @default.
• W2891836041 creator A5029068179 @default.
• W2891836041 creator A5030403208 @default.
• W2891836041 creator A5036337517 @default.
• W2891836041 creator A5047811024 @default.
• W2891836041 creator A5055402437 @default.
• W2891836041 creator A5089665448 @default.
• W2891836041 date "2018-09-19" @default.
• W2891836041 modified "2023-10-17" @default.
• W2891836041 title "α-Tocopheryl Succinate-Based Polymeric Nanoparticles for the Treatment of Head and Neck Squamous Cell Carcinoma" @default.
• W2891836041 cites W1543678657 @default.
• W2891836041 cites W1984483611 @default.
• W2891836041 cites W1987711340 @default.
• W2891836041 cites W1990412352 @default.
• W2891836041 cites W1994440366 @default.
• W2891836041 cites W2000292756 @default.
• W2891836041 cites W2001071264 @default.
• W2891836041 cites W2002286451 @default.
• W2891836041 cites W2017692041 @default.
• W2891836041 cites W2022234182 @default.
• W2891836041 cites W2026841252 @default.
• W2891836041 cites W2028721376 @default.
• W2891836041 cites W2029155479 @default.
• W2891836041 cites W2038750765 @default.
• W2891836041 cites W2040231508 @default.
• W2891836041 cites W2047803864 @default.
• W2891836041 cites W2071062791 @default.
• W2891836041 cites W2081005846 @default.
• W2891836041 cites W2087912166 @default.
• W2891836041 cites W2099653180 @default.
• W2891836041 cites W2103433464 @default.
• W2891836041 cites W2121291860 @default.
• W2891836041 cites W2125301636 @default.
• W2891836041 cites W2136358086 @default.
• W2891836041 cites W2154502317 @default.
• W2891836041 cites W2155879201 @default.
• W2891836041 cites W2157354207 @default.
• W2891836041 cites W2159365184 @default.
• W2891836041 cites W2162317646 @default.
• W2891836041 cites W2189272099 @default.
• W2891836041 cites W2191460593 @default.
• W2891836041 cites W2327683973 @default.
• W2891836041 cites W2462900154 @default.
• W2891836041 cites W2530529985 @default.
• W2891836041 cites W2588828394 @default.
• W2891836041 cites W2793323124 @default.
• W2891836041 cites W4245635197 @default.
• W2891836041 doi "https://doi.org/10.3390/biom8030097" @default.
• W2891836041 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6164389" @default.
• W2891836041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30235821" @default.
• W2891836041 hasPublicationYear "2018" @default.
• W2891836041 type Work @default.
• W2891836041 sameAs 2891836041 @default.
• W2891836041 citedByCount "16" @default.
• W2891836041 countsByYear W28918360412019 @default.
• W2891836041 countsByYear W28918360412020 @default.
• W2891836041 countsByYear W28918360412021 @default.
• W2891836041 countsByYear W28918360412022 @default.
• W2891836041 countsByYear W28918360412023 @default.
• W2891836041 crossrefType "journal-article" @default.
• W2891836041 hasAuthorship W2891836041A5018438022 @default.
• W2891836041 hasAuthorship W2891836041A5029068179 @default.
• W2891836041 hasAuthorship W2891836041A5030403208 @default.
• W2891836041 hasAuthorship W2891836041A5036337517 @default.
• W2891836041 hasAuthorship W2891836041A5047811024 @default.
• W2891836041 hasAuthorship W2891836041A5055402437 @default.
• W2891836041 hasAuthorship W2891836041A5089665448 @default.
• W2891836041 hasBestOaLocation W28918360411 @default.
• W2891836041 hasConcept C109523444 @default.
• W2891836041 hasConcept C121608353 @default.
• W2891836041 hasConcept C126322002 @default.
• W2891836041 hasConcept C142724271 @default.
• W2891836041 hasConcept C1491633281 @default.
• W2891836041 hasConcept C167734588 @default.
• W2891836041 hasConcept C185592680 @default.
• W2891836041 hasConcept C190283241 @default.
• W2891836041 hasConcept C202751555 @default.
• W2891836041 hasConcept C2776530083 @default.
• W2891836041 hasConcept C2776833033 @default.
• W2891836041 hasConcept C2777025900 @default.
• W2891836041 hasConcept C2777546739 @default.
• W2891836041 hasConcept C2780394083 @default.
• W2891836041 hasConcept C2994491419 @default.
• W2891836041 hasConcept C48349386 @default.
• W2891836041 hasConcept C502942594 @default.
• W2891836041 hasConcept C55493867 @default.
• W2891836041 hasConcept C71924100 @default.
• W2891836041 hasConcept C86803240 @default.
• W2891836041 hasConceptScore W2891836041C109523444 @default.
• W2891836041 hasConceptScore W2891836041C121608353 @default.
• W2891836041 hasConceptScore W2891836041C126322002 @default.
• W2891836041 hasConceptScore W2891836041C142724271 @default.
• W2891836041 hasConceptScore W2891836041C1491633281 @default.
• W2891836041 hasConceptScore W2891836041C167734588 @default.
• W2891836041 hasConceptScore W2891836041C185592680 @default.
• W2891836041 hasConceptScore W2891836041C190283241 @default.

• next