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• W2891838265 startingPage "2860" @default.
• W2891838265 abstract "Background: Peroxisome proliferator–activated receptor (PPAR) β/δ, a ligand-activated transcription factor, is involved in diverse biological processes including cell proliferation, cell differentiation, inflammation and energy homeostasis. Besides its well-established roles in metabolic disorders, PPARβ/δ has been linked to carcinogenesis and was reported to inhibit melanoma cell proliferation, anchorage-dependent clonogenicity and ectopic xenograft tumorigenicity. However, PPARβ/δ’s role in tumour progression and metastasis remains controversial. Methods: In the present studies, the consequence of PPARβ/δ inhibition either by global genetic deletion or by a specific PPARβ/δ antagonist, 10h, on malignant transformation of melanoma cells and melanoma metastasis was examined using both in vitro and in vivo models. Results: Our study showed that 10h promotes epithelial-mesenchymal transition (EMT), migration, adhesion, invasion and trans-endothelial migration of mouse melanoma B16/F10 cells. We further demonstrated an increased tumour cell extravasation in the lungs of wild-type mice subjected to 10h treatment and in Pparβ/δ−/− mice in an experimental mouse model of blood-borne pulmonary metastasis by tail vein injection. This observation was further supported by an increased tumour burden in the lungs of Pparβ/δ−/− mice as demonstrated in the same animal model. Conclusion: These results indicated a protective role of PPARβ/δ in melanoma progression and metastasis." @default.
• W2891838265 created "2018-09-27" @default.
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• W2891838265 date "2018-09-20" @default.
• W2891838265 modified "2023-10-15" @default.
• W2891838265 title "The Role of PPARβ/δ in Melanoma Metastasis" @default.
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• W2891838265 doi "https://doi.org/10.3390/ijms19102860" @default.
• W2891838265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6213649" @default.
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• W2891838265 hasPublicationYear "2018" @default.
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