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- W2891838654 abstract "Abstract The O‐linked N ‐acetylglucosamine ( O ‐GlcNAc) modification is an essential component in cell regulation. A single pair of human enzymes conducts this modification dynamically on a broad variety of proteins: O ‐GlcNAc transferase (OGT) adds the GlcNAc residue and O ‐GlcNAcase (OGA) hydrolyzes it. This modification is dysregulated in many diseases, but its exact effect on particular substrates remains unclear. In addition, no apparent sequence motif has been found in the modified proteins, and the factors controlling the substrate specificity of OGT and OGA are largely unknown. In this minireview, we will discuss recent developments in chemical and biochemical methods toward addressing the challenge of OGT and OGA substrate recognition. We hope that the new concepts and knowledge from these studies will promote research in this area to advance understanding of O ‐GlcNAc regulation in health and disease." @default.
- W2891838654 created "2018-09-27" @default.
- W2891838654 creator A5002715793 @default.
- W2891838654 creator A5035422570 @default.
- W2891838654 creator A5044708390 @default.
- W2891838654 creator A5060328542 @default.
- W2891838654 date "2018-11-12" @default.
- W2891838654 modified "2023-10-06" @default.
- W2891838654 title "Chemical and Biochemical Strategies To Explore the Substrate Recognition of <i>O</i> ‐GlcNAc‐Cycling Enzymes" @default.
- W2891838654 cites W1481480776 @default.
- W2891838654 cites W1568866400 @default.
- W2891838654 cites W1763148417 @default.
- W2891838654 cites W1965355119 @default.
- W2891838654 cites W1966824956 @default.
- W2891838654 cites W1974694294 @default.
- W2891838654 cites W1978029178 @default.
- W2891838654 cites W1986758311 @default.
- W2891838654 cites W1992665990 @default.
- W2891838654 cites W1997087248 @default.
- W2891838654 cites W2002888609 @default.
- W2891838654 cites W2016036293 @default.
- W2891838654 cites W2022428368 @default.
- W2891838654 cites W2028423178 @default.
- W2891838654 cites W2030857654 @default.
- W2891838654 cites W2031087463 @default.
- W2891838654 cites W2034286717 @default.
- W2891838654 cites W2034457197 @default.
- W2891838654 cites W2035124967 @default.
- W2891838654 cites W2041967294 @default.
- W2891838654 cites W2048212725 @default.
- W2891838654 cites W2050775180 @default.
- W2891838654 cites W2051494794 @default.
- W2891838654 cites W2052135200 @default.
- W2891838654 cites W2059556669 @default.
- W2891838654 cites W2059725389 @default.
- W2891838654 cites W2068805128 @default.
- W2891838654 cites W2070991372 @default.
- W2891838654 cites W2078226521 @default.
- W2891838654 cites W2088321697 @default.
- W2891838654 cites W2090211150 @default.
- W2891838654 cites W2098197423 @default.
- W2891838654 cites W2099242251 @default.
- W2891838654 cites W2100437353 @default.
- W2891838654 cites W2100614964 @default.
- W2891838654 cites W2105707485 @default.
- W2891838654 cites W2107089340 @default.
- W2891838654 cites W2107601138 @default.
- W2891838654 cites W2108929776 @default.
- W2891838654 cites W2113379985 @default.
- W2891838654 cites W2116095417 @default.
- W2891838654 cites W2116227340 @default.
- W2891838654 cites W2118903190 @default.
- W2891838654 cites W2120036668 @default.
- W2891838654 cites W2120251241 @default.
- W2891838654 cites W2125740601 @default.
- W2891838654 cites W2143963279 @default.
- W2891838654 cites W2155290518 @default.
- W2891838654 cites W2156864264 @default.
- W2891838654 cites W2160033413 @default.
- W2891838654 cites W2161402141 @default.
- W2891838654 cites W2169486515 @default.
- W2891838654 cites W2172247109 @default.
- W2891838654 cites W2180342052 @default.
- W2891838654 cites W2214552500 @default.
- W2891838654 cites W2233739953 @default.
- W2891838654 cites W2294128808 @default.
- W2891838654 cites W2302527426 @default.
- W2891838654 cites W2321939831 @default.
- W2891838654 cites W2328732985 @default.
- W2891838654 cites W2343796589 @default.
- W2891838654 cites W2347067222 @default.
- W2891838654 cites W2434992191 @default.
- W2891838654 cites W2464384284 @default.
- W2891838654 cites W2566332558 @default.
- W2891838654 cites W2568219433 @default.
- W2891838654 cites W2589903105 @default.
- W2891838654 cites W2595453884 @default.
- W2891838654 cites W2601233071 @default.
- W2891838654 cites W2601432239 @default.
- W2891838654 cites W2603194836 @default.
- W2891838654 cites W2619937372 @default.
- W2891838654 cites W2623401869 @default.
- W2891838654 cites W2727734411 @default.
- W2891838654 cites W2731442884 @default.
- W2891838654 cites W2742828134 @default.
- W2891838654 cites W2756444346 @default.
- W2891838654 cites W2766375531 @default.
- W2891838654 cites W2774343788 @default.
- W2891838654 cites W2789760611 @default.
- W2891838654 cites W2792569921 @default.
- W2891838654 cites W2795111905 @default.
- W2891838654 cites W2804822924 @default.
- W2891838654 cites W2809206870 @default.
- W2891838654 cites W2885819237 @default.
- W2891838654 cites W4248905626 @default.
- W2891838654 doi "https://doi.org/10.1002/cbic.201800481" @default.
- W2891838654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6433133" @default.
- W2891838654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30199580" @default.