FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891843407> ?p ?o ?g. }

• W2891843407 abstract "Natural killer (NK) cells are important for maintenance of innate immune system stability and serve as a first line of defense against tumors and virus infections; they can act either directly or indirectly and are regulated via co-operation between inhibitory and stimulatory surface receptors. The recently reported inhibitory receptor, TIGIT, can be expressed on the NK cell surface; however, the expression level and function of TIGIT on NK cells during HIV infection is unknown. In this study, for the first time, we investigated the expression and function of TIGIT in NK cells from HIV-infected individuals. Our data demonstrate that the level of TIGIT is higher on NK cells from patients infected with human immunodeficiency virus (HIV) compared with HIV-negative healthy controls. TIGIT expression is inversely correlated with CD4+ T cell counts and positively correlated with plasma viral loads. Additionally, levels of the TIGIT ligand, CD155, were higher on CD4+ T cells from HIV-infected individuals compared with those from healthy controls; however, there was no difference in the level of the activating receptor, CD226, which recognizes the same ligands as TIGIT. Furthermore, TIGIT was found to specifically up-regulated on CD226+ NK cells in HIV-infected individuals, and either rIL-10, or rIL-12 + rIL-15, could induce TIGIT expression on these cells. In addition, high TIGIT expression inhibited the production of interferon-gamma (IFN-γ) by NK cells, while TIGIT inhibition restored IFN-γ production. Overall, these results highlight the important role of TIGIT in NK cell function and suggest a potential new avenue for the development of therapeutic strategies toward a functional cure for HIV." @default.
• W2891843407 created "2018-09-27" @default.
• W2891843407 creator A5001341467 @default.
• W2891843407 creator A5004558416 @default.
• W2891843407 creator A5006924076 @default.
• W2891843407 creator A5030460543 @default.
• W2891843407 creator A5043636220 @default.
• W2891843407 creator A5046008764 @default.
• W2891843407 creator A5076863688 @default.
• W2891843407 creator A5077095023 @default.
• W2891843407 creator A5079816979 @default.
• W2891843407 creator A5080268249 @default.
• W2891843407 creator A5081751889 @default.
• W2891843407 creator A5086076339 @default.
• W2891843407 creator A5090911302 @default.
• W2891843407 date "2018-10-10" @default.
• W2891843407 modified "2023-10-14" @default.
• W2891843407 title "Expression of the Inhibitory Receptor TIGIT Is Up-Regulated Specifically on NK Cells With CD226 Activating Receptor From HIV-Infected Individuals" @default.
• W2891843407 cites W1504038693 @default.
• W2891843407 cites W1824529173 @default.
• W2891843407 cites W1913881492 @default.
• W2891843407 cites W1966128754 @default.
• W2891843407 cites W1969814796 @default.
• W2891843407 cites W1972338421 @default.
• W2891843407 cites W1977797737 @default.
• W2891843407 cites W1980853178 @default.
• W2891843407 cites W1983812780 @default.
• W2891843407 cites W1993596892 @default.
• W2891843407 cites W1999689279 @default.
• W2891843407 cites W2006054189 @default.
• W2891843407 cites W2008078642 @default.
• W2891843407 cites W2008847523 @default.
• W2891843407 cites W2017678578 @default.
• W2891843407 cites W2023044372 @default.
• W2891843407 cites W2046409157 @default.
• W2891843407 cites W2050317788 @default.
• W2891843407 cites W2050457398 @default.
• W2891843407 cites W2059467769 @default.
• W2891843407 cites W2067893593 @default.
• W2891843407 cites W2073303594 @default.
• W2891843407 cites W2076248543 @default.
• W2891843407 cites W2081118119 @default.
• W2891843407 cites W2081484203 @default.
• W2891843407 cites W2087590625 @default.
• W2891843407 cites W2099854994 @default.
• W2891843407 cites W2100285658 @default.
• W2891843407 cites W2101808318 @default.
• W2891843407 cites W2109197060 @default.
• W2891843407 cites W2136738141 @default.
• W2891843407 cites W2144201925 @default.
• W2891843407 cites W2152655560 @default.
• W2891843407 cites W2154832903 @default.
• W2891843407 cites W2165173534 @default.
• W2891843407 cites W2165920713 @default.
• W2891843407 cites W2166198180 @default.
• W2891843407 cites W2168914393 @default.
• W2891843407 cites W2223927775 @default.
• W2891843407 cites W2225639217 @default.
• W2891843407 cites W2264623162 @default.
• W2891843407 cites W2271212716 @default.
• W2891843407 cites W2315500778 @default.
• W2891843407 cites W2403400382 @default.
• W2891843407 cites W2510796782 @default.
• W2891843407 cites W2520704033 @default.
• W2891843407 cites W2577091647 @default.
• W2891843407 cites W2587354014 @default.
• W2891843407 cites W2611440564 @default.
• W2891843407 cites W2616838116 @default.
• W2891843407 cites W2626558431 @default.
• W2891843407 cites W2732557031 @default.
• W2891843407 cites W2753155927 @default.
• W2891843407 cites W2753973552 @default.
• W2891843407 cites W2755898996 @default.
• W2891843407 cites W2762253884 @default.
• W2891843407 cites W2765258754 @default.
• W2891843407 cites W2808601843 @default.
• W2891843407 cites W3146625568 @default.
• W2891843407 doi "https://doi.org/10.3389/fimmu.2018.02341" @default.
• W2891843407 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6192288" @default.
• W2891843407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30364127" @default.
• W2891843407 hasPublicationYear "2018" @default.
• W2891843407 type Work @default.
• W2891843407 sameAs 2891843407 @default.
• W2891843407 citedByCount "42" @default.
• W2891843407 countsByYear W28918434072019 @default.
• W2891843407 countsByYear W28918434072020 @default.
• W2891843407 countsByYear W28918434072021 @default.
• W2891843407 countsByYear W28918434072022 @default.
• W2891843407 countsByYear W28918434072023 @default.
• W2891843407 crossrefType "journal-article" @default.
• W2891843407 hasAuthorship W2891843407A5001341467 @default.
• W2891843407 hasAuthorship W2891843407A5004558416 @default.
• W2891843407 hasAuthorship W2891843407A5006924076 @default.
• W2891843407 hasAuthorship W2891843407A5030460543 @default.
• W2891843407 hasAuthorship W2891843407A5043636220 @default.
• W2891843407 hasAuthorship W2891843407A5046008764 @default.
• W2891843407 hasAuthorship W2891843407A5076863688 @default.
• W2891843407 hasAuthorship W2891843407A5077095023 @default.
• W2891843407 hasAuthorship W2891843407A5079816979 @default.
• W2891843407 hasAuthorship W2891843407A5080268249 @default.

• next