FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891846231> ?p ?o ?g. }

• W2891846231 endingPage "e0203218" @default.
• W2891846231 startingPage "e0203218" @default.
• W2891846231 abstract "Luciferases, aryl- and fatty-acyl CoA synthetases, and non-ribosomal peptide synthetase proteins belong to the class I adenylate-forming enzyme superfamily. The reaction catalyzed by the adenylate-forming enzymes is categorized by a two-step process of adenylation and thioesterification. Although all of these proteins perform a similar two-step process, each family may perform the process to yield completely different results. For example, luciferase proteins perform adenylation and oxidation to produce the green fluorescent light found in fireflies, while fatty-acyl CoA synthetases perform adenylation and thioesterification with coenzyme A to assist in metabolic processes involving fatty acids. This study aligned a total of 374 sequences belonging to the adenylate-forming superfamily. Analysis of the sequences revealed five fully conserved residues throughout all sequences, as well as 78 more residues conserved in at least 60% of sequences aligned. Conserved positions are involved in magnesium and AMP binding and maintaining enzyme structure. Also, ten conserved sequence motifs that included most of the conserved residues were identified. A phylogenetic tree was used to assign sequences into nine different groups. Finally, group entropy analysis identified novel conservations unique to each enzyme group. Common group-specific positions identified in multiple groups include positions critical to coordinating AMP and the CoA-bound product, a position that governs active site shape, and positions that help to maintain enzyme structure through hydrogen bonds and hydrophobic interactions. These positions could serve as excellent targets for future research." @default.
• W2891846231 created "2018-09-27" @default.
• W2891846231 creator A5010340297 @default.
• W2891846231 creator A5015528013 @default.
• W2891846231 creator A5019087807 @default.
• W2891846231 creator A5086188795 @default.
• W2891846231 creator A5091840898 @default.
• W2891846231 date "2018-09-04" @default.
• W2891846231 modified "2023-10-16" @default.
• W2891846231 title "In silico analysis of class I adenylate-forming enzymes reveals family and group-specific conservations" @default.
• W2891846231 cites W1507146373 @default.
• W2891846231 cites W1592870802 @default.
• W2891846231 cites W1937835538 @default.
• W2891846231 cites W1964412051 @default.
• W2891846231 cites W1966524255 @default.
• W2891846231 cites W1967293793 @default.
• W2891846231 cites W1969084293 @default.
• W2891846231 cites W1970386034 @default.
• W2891846231 cites W1972088519 @default.
• W2891846231 cites W1972237148 @default.
• W2891846231 cites W1979656018 @default.
• W2891846231 cites W1980453640 @default.
• W2891846231 cites W1980566465 @default.
• W2891846231 cites W1980776509 @default.
• W2891846231 cites W1981020055 @default.
• W2891846231 cites W1984216534 @default.
• W2891846231 cites W1985381418 @default.
• W2891846231 cites W1987697800 @default.
• W2891846231 cites W1990781448 @default.
• W2891846231 cites W2000248841 @default.
• W2891846231 cites W2003583751 @default.
• W2891846231 cites W2018990299 @default.
• W2891846231 cites W2020471978 @default.
• W2891846231 cites W2026258231 @default.
• W2891846231 cites W2028669766 @default.
• W2891846231 cites W2034111644 @default.
• W2891846231 cites W2040799957 @default.
• W2891846231 cites W2041723357 @default.
• W2891846231 cites W2043400011 @default.
• W2891846231 cites W2050544107 @default.
• W2891846231 cites W2056541157 @default.
• W2891846231 cites W2057786676 @default.
• W2891846231 cites W2060063308 @default.
• W2891846231 cites W2074473216 @default.
• W2891846231 cites W2077913471 @default.
• W2891846231 cites W2085085319 @default.
• W2891846231 cites W2086441524 @default.
• W2891846231 cites W2086986829 @default.
• W2891846231 cites W2088860725 @default.
• W2891846231 cites W2095181192 @default.
• W2891846231 cites W2097642323 @default.
• W2891846231 cites W2097856810 @default.
• W2891846231 cites W2102680156 @default.
• W2891846231 cites W2105110220 @default.
• W2891846231 cites W2110148542 @default.
• W2891846231 cites W2115888213 @default.
• W2891846231 cites W2120358131 @default.
• W2891846231 cites W2124904122 @default.
• W2891846231 cites W2127538703 @default.
• W2891846231 cites W2129941226 @default.
• W2891846231 cites W2130446649 @default.
• W2891846231 cites W2131510173 @default.
• W2891846231 cites W2132629607 @default.
• W2891846231 cites W2134815007 @default.
• W2891846231 cites W2135997639 @default.
• W2891846231 cites W2137991504 @default.
• W2891846231 cites W2141560453 @default.
• W2891846231 cites W2144362290 @default.
• W2891846231 cites W2150444353 @default.
• W2891846231 cites W2150953856 @default.
• W2891846231 cites W2153352437 @default.
• W2891846231 cites W2154582742 @default.
• W2891846231 cites W2154714625 @default.
• W2891846231 cites W2154899683 @default.
• W2891846231 cites W2157428744 @default.
• W2891846231 cites W2157959147 @default.
• W2891846231 cites W2158714788 @default.
• W2891846231 cites W2162292142 @default.
• W2891846231 cites W2163692914 @default.
• W2891846231 cites W2167116010 @default.
• W2891846231 cites W2169890434 @default.
• W2891846231 cites W2277960723 @default.
• W2891846231 cites W2300469513 @default.
• W2891846231 cites W2509989231 @default.
• W2891846231 cites W2549449350 @default.
• W2891846231 cites W2557368150 @default.
• W2891846231 cites W2600677235 @default.
• W2891846231 cites W2740860003 @default.
• W2891846231 cites W2758716732 @default.
• W2891846231 cites W4244410612 @default.
• W2891846231 doi "https://doi.org/10.1371/journal.pone.0203218" @default.
• W2891846231 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6122825" @default.
• W2891846231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30180199" @default.
• W2891846231 hasPublicationYear "2018" @default.
• W2891846231 type Work @default.
• W2891846231 sameAs 2891846231 @default.
• W2891846231 citedByCount "10" @default.
• W2891846231 countsByYear W28918462312019 @default.

• next