FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891847667> ?p ?o ?g. }

• W2891847667 endingPage "2052" @default.
• W2891847667 startingPage "2041" @default.
• W2891847667 abstract "To evaluate four models based on potential predictors for achieving a response to pregabalin treatment for neuropathic pain (NeP).In total, 46 pain studies were screened, of which 27 NeP studies met the criteria for inclusion in this analysis. Data were pooled from these 27 placebo-controlled randomized trials to assess if baseline characteristics (including mean pain and pain-related sleep interference [PRSI] scores), early clinical response during weeks 1-3 of treatment (change from baseline in pain and PRSI scores), and presence of treatment-emergent adverse events (AEs) were predictive of therapeutic response. Therapeutic response was defined as a ≥30% reduction from baseline in either pain and/or PRSI scores at week 5 with supplemental analyses to predict pain outcomes at weeks 8 and 12. Predictors of Patient Global Impression of Change (PGIC) were also evaluated. Four models were assessed: Random Forest, Logistic Regression, Naïve Bayes, and Partial Least Squares.The number of pregabalin-treated subjects in the training/test datasets, respectively, were 2818/1407 (30% pain analysis), 2812/1405 (30% sleep analysis), and 2693/1345 (PGIC analysis). All four models demonstrated consistent results, and the most important predictors of treatment outcomes at week 5 and pain outcomes at weeks 8 and 12 were the reduction in pain score and sleep score in the first 1-3 weeks. The presence or absence of the most common AEs in the first 1-3 weeks was not correlated with any treatment outcome.Subjects with an early response to pregabalin are more likely to experience an end-of-treatment response." @default.
• W2891847667 created "2018-09-27" @default.
• W2891847667 creator A5021885089 @default.
• W2891847667 creator A5042073172 @default.
• W2891847667 creator A5085960628 @default.
• W2891847667 date "2018-10-18" @default.
• W2891847667 modified "2023-10-01" @default.
• W2891847667 title "Prediction of therapeutic response to pregabalin in subjects with neuropathic pain" @default.
• W2891847667 cites W1476661220 @default.
• W2891847667 cites W1504268385 @default.
• W2891847667 cites W1542127021 @default.
• W2891847667 cites W1560046035 @default.
• W2891847667 cites W1569152250 @default.
• W2891847667 cites W1576673253 @default.
• W2891847667 cites W1845521331 @default.
• W2891847667 cites W1972387365 @default.
• W2891847667 cites W2005396232 @default.
• W2891847667 cites W2011913908 @default.
• W2891847667 cites W2013925555 @default.
• W2891847667 cites W2017252560 @default.
• W2891847667 cites W2034740144 @default.
• W2891847667 cites W2038826804 @default.
• W2891847667 cites W2054260401 @default.
• W2891847667 cites W2068602147 @default.
• W2891847667 cites W2068757724 @default.
• W2891847667 cites W2070246197 @default.
• W2891847667 cites W2076716839 @default.
• W2891847667 cites W2076964900 @default.
• W2891847667 cites W2083355677 @default.
• W2891847667 cites W2094822188 @default.
• W2891847667 cites W2101211236 @default.
• W2891847667 cites W2102434957 @default.
• W2891847667 cites W2104818454 @default.
• W2891847667 cites W2127894556 @default.
• W2891847667 cites W2132309748 @default.
• W2891847667 cites W2136415182 @default.
• W2891847667 cites W2152802140 @default.
• W2891847667 cites W2158523533 @default.
• W2891847667 cites W2159977024 @default.
• W2891847667 cites W2161563980 @default.
• W2891847667 cites W2167864730 @default.
• W2891847667 cites W2280631568 @default.
• W2891847667 cites W2328100319 @default.
• W2891847667 cites W2567170115 @default.
• W2891847667 cites W429766147 @default.
• W2891847667 doi "https://doi.org/10.1080/03007995.2018.1520694" @default.
• W2891847667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30183410" @default.
• W2891847667 hasPublicationYear "2018" @default.
• W2891847667 type Work @default.
• W2891847667 sameAs 2891847667 @default.
• W2891847667 citedByCount "4" @default.
• W2891847667 countsByYear W28918476672019 @default.
• W2891847667 countsByYear W28918476672021 @default.
• W2891847667 countsByYear W28918476672022 @default.
• W2891847667 crossrefType "journal-article" @default.
• W2891847667 hasAuthorship W2891847667A5021885089 @default.
• W2891847667 hasAuthorship W2891847667A5042073172 @default.
• W2891847667 hasAuthorship W2891847667A5085960628 @default.
• W2891847667 hasConcept C126322002 @default.
• W2891847667 hasConcept C142724271 @default.
• W2891847667 hasConcept C151956035 @default.
• W2891847667 hasConcept C168563851 @default.
• W2891847667 hasConcept C1862650 @default.
• W2891847667 hasConcept C197934379 @default.
• W2891847667 hasConcept C204787440 @default.
• W2891847667 hasConcept C27081682 @default.
• W2891847667 hasConcept C2776468701 @default.
• W2891847667 hasConcept C2777107010 @default.
• W2891847667 hasConcept C42219234 @default.
• W2891847667 hasConcept C71924100 @default.
• W2891847667 hasConceptScore W2891847667C126322002 @default.
• W2891847667 hasConceptScore W2891847667C142724271 @default.
• W2891847667 hasConceptScore W2891847667C151956035 @default.
• W2891847667 hasConceptScore W2891847667C168563851 @default.
• W2891847667 hasConceptScore W2891847667C1862650 @default.
• W2891847667 hasConceptScore W2891847667C197934379 @default.
• W2891847667 hasConceptScore W2891847667C204787440 @default.
• W2891847667 hasConceptScore W2891847667C27081682 @default.
• W2891847667 hasConceptScore W2891847667C2776468701 @default.
• W2891847667 hasConceptScore W2891847667C2777107010 @default.
• W2891847667 hasConceptScore W2891847667C42219234 @default.
• W2891847667 hasConceptScore W2891847667C71924100 @default.
• W2891847667 hasIssue "12" @default.
• W2891847667 hasLocation W28918476671 @default.
• W2891847667 hasLocation W28918476672 @default.
• W2891847667 hasOpenAccess W2891847667 @default.
• W2891847667 hasPrimaryLocation W28918476671 @default.
• W2891847667 hasRelatedWork W2054234757 @default.
• W2891847667 hasRelatedWork W2159872359 @default.
• W2891847667 hasRelatedWork W2322691812 @default.
• W2891847667 hasRelatedWork W2384186610 @default.
• W2891847667 hasRelatedWork W2460229242 @default.
• W2891847667 hasRelatedWork W2514576596 @default.
• W2891847667 hasRelatedWork W2919765778 @default.
• W2891847667 hasRelatedWork W3023007364 @default.
• W2891847667 hasRelatedWork W4240200920 @default.
• W2891847667 hasRelatedWork W76548576 @default.
• W2891847667 hasVolume "34" @default.

• next