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- W2891848497 abstract "Series of half-sandwich IrIII N-heterocyclic carbene (NHC) antitumor complexes [(η5-Cp*)Ir(C^C)Cl] have been synthesized and characterized (Cp* is pentamethyl cyclopentadienyl, and C^C are four NHC chelating ligands containing phenyl rings at different positions). IrIII complexes showed potent antitumor activity with IC50 values ranged from 3.9 to 11.8 μM against A549 cells by the MTT assay. Complexes can catalyze the conversion of the coenzyme NADH to NAD+ and induce the production of reactive oxygen species (ROS), and bonding to BSA by static quenching mode. Complexes can arrest the cell cycle in G1 or S phase and reduce the mitochondrial membrane potential. Confocal microscopy test show complexes could target the lysosome and mitochondria in cells with the Pearson's colocalization coefficient of 0.82 and 0.21 after 12 h, respectively, and followed by an energy-dependent cellular uptake mechanism." @default.
- W2891848497 created "2018-09-27" @default.
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- W2891848497 date "2018-12-01" @default.
- W2891848497 modified "2023-10-13" @default.
- W2891848497 title "Half-sandwich IridiumIII N-heterocyclic carbene antitumor complexes and biological applications" @default.
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- W2891848497 doi "https://doi.org/10.1016/j.jinorgbio.2018.09.009" @default.
- W2891848497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30268969" @default.
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