FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891852313> ?p ?o ?g. }

• W2891852313 abstract "Pneumonia is an important issue for sheep production, leading to reduced growth rate and a predisposition to pleurisy. The objective of this study was to identify loci associated with pneumonic lesions and pleurisy in New Zealand progeny test lambs. The lungs from 3,572 progeny-test lambs were scored for presence and severity of pneumonic lesions and pleurisy at slaughter. Animals were genotyped using the Illumina Ovine Infinium HD SNP BeadChip (606,006 markers). The heritability of lung lesion score and pleurisy were calculated using the genomic relationship matrix, and genome-wide association analyses were conducted using EMMAX and haplotype trend regression. At slaughter, 35% of lambs had pneumonic lesions, with 9% showing lesions on more than half of any individual lobe. The number of lambs recorded as having pleurisy by the processing plants was 9%. Heritability estimates for pneumonic lesions and pleurisy scores adjusted for heteroscedasticity (CPSa and PLEURa) were 0.16 (± 0.03) and 0.05 (± 0.02), respectively. Five single-nucleotide polymorphisms (SNPs) were significantly associated with pneumonic lesions at the genome-wide level, and additional 37 SNPs were suggestively significant. Four SNPs were significantly associated with pleurisy, with an additional 11 SNPs reaching the suggestive level of significance. There were no regions that overlapped between the 2 traits. Multiple SNPs were in regions that contained genes involved in either the DNA damage response or the innate immune response, including several that had previously been reported to have associations with respiratory disease. Both EMMAX and HTR analyses of pleurisy data showed a significant peak on chromosome 2, located downstream from the transcription factor SP3. SP3 activates or suppresses the expression of numerous genes, including several genes with known functions in the immune system. This study identified several SNPs associated with genes involved in both the innate immune response and the response to DNA damage that are associated with pneumonic lesions and pleurisy in lambs at slaughter. Additionally, the identification in sheep of several SNPs within genes that have previously been associated with the respiratory system in cattle, pigs, rats, and mice indicates that there may be common pathways that underlie the response to invasion by respiratory pathogens in multiple species." @default.
• W2891852313 created "2018-09-27" @default.
• W2891852313 creator A5002283699 @default.
• W2891852313 creator A5002400154 @default.
• W2891852313 creator A5030565870 @default.
• W2891852313 creator A5053867015 @default.
• W2891852313 creator A5061980120 @default.
• W2891852313 date "2018-08-06" @default.
• W2891852313 modified "2023-09-27" @default.
• W2891852313 title "Genome-wide association study of lung lesions and pleurisy in New Zealand lambs1" @default.
• W2891852313 cites W1504352651 @default.
• W2891852313 cites W1817548159 @default.
• W2891852313 cites W1878212120 @default.
• W2891852313 cites W1964862399 @default.
• W2891852313 cites W1970161334 @default.
• W2891852313 cites W1983477421 @default.
• W2891852313 cites W1987130013 @default.
• W2891852313 cites W1988997130 @default.
• W2891852313 cites W1998044858 @default.
• W2891852313 cites W2008262104 @default.
• W2891852313 cites W2033534375 @default.
• W2891852313 cites W2052676868 @default.
• W2891852313 cites W2053755275 @default.
• W2891852313 cites W2056212533 @default.
• W2891852313 cites W2056622279 @default.
• W2891852313 cites W2062511407 @default.
• W2891852313 cites W2063350250 @default.
• W2891852313 cites W2067403800 @default.
• W2891852313 cites W2070919286 @default.
• W2891852313 cites W2074036892 @default.
• W2891852313 cites W2093321273 @default.
• W2891852313 cites W2102534372 @default.
• W2891852313 cites W2110005053 @default.
• W2891852313 cites W2116948221 @default.
• W2891852313 cites W2134552197 @default.
• W2891852313 cites W2135465011 @default.
• W2891852313 cites W2144109825 @default.
• W2891852313 cites W2157912448 @default.
• W2891852313 cites W2161245845 @default.
• W2891852313 cites W2163746227 @default.
• W2891852313 cites W2234118937 @default.
• W2891852313 cites W2554188288 @default.
• W2891852313 doi "https://doi.org/10.1093/jas/sky323" @default.
• W2891852313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6247835" @default.
• W2891852313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30099550" @default.
• W2891852313 hasPublicationYear "2018" @default.
• W2891852313 type Work @default.
• W2891852313 sameAs 2891852313 @default.
• W2891852313 citedByCount "0" @default.
• W2891852313 crossrefType "journal-article" @default.
• W2891852313 hasAuthorship W2891852313A5002283699 @default.
• W2891852313 hasAuthorship W2891852313A5002400154 @default.
• W2891852313 hasAuthorship W2891852313A5030565870 @default.
• W2891852313 hasAuthorship W2891852313A5053867015 @default.
• W2891852313 hasAuthorship W2891852313A5061980120 @default.
• W2891852313 hasBestOaLocation W28918523131 @default.
• W2891852313 hasConcept C104317684 @default.
• W2891852313 hasConcept C126322002 @default.
• W2891852313 hasConcept C135763542 @default.
• W2891852313 hasConcept C139275648 @default.
• W2891852313 hasConcept C142724271 @default.
• W2891852313 hasConcept C153209595 @default.
• W2891852313 hasConcept C2777914695 @default.
• W2891852313 hasConcept C2778978224 @default.
• W2891852313 hasConcept C2779634585 @default.
• W2891852313 hasConcept C54355233 @default.
• W2891852313 hasConcept C71924100 @default.
• W2891852313 hasConcept C86803240 @default.
• W2891852313 hasConceptScore W2891852313C104317684 @default.
• W2891852313 hasConceptScore W2891852313C126322002 @default.
• W2891852313 hasConceptScore W2891852313C135763542 @default.
• W2891852313 hasConceptScore W2891852313C139275648 @default.
• W2891852313 hasConceptScore W2891852313C142724271 @default.
• W2891852313 hasConceptScore W2891852313C153209595 @default.
• W2891852313 hasConceptScore W2891852313C2777914695 @default.
• W2891852313 hasConceptScore W2891852313C2778978224 @default.
• W2891852313 hasConceptScore W2891852313C2779634585 @default.
• W2891852313 hasConceptScore W2891852313C54355233 @default.
• W2891852313 hasConceptScore W2891852313C71924100 @default.
• W2891852313 hasConceptScore W2891852313C86803240 @default.
• W2891852313 hasLocation W28918523131 @default.
• W2891852313 hasLocation W28918523132 @default.
• W2891852313 hasLocation W28918523133 @default.
• W2891852313 hasLocation W28918523134 @default.
• W2891852313 hasOpenAccess W2891852313 @default.
• W2891852313 hasPrimaryLocation W28918523131 @default.
• W2891852313 hasRelatedWork W1574352484 @default.
• W2891852313 hasRelatedWork W1986074241 @default.
• W2891852313 hasRelatedWork W1997352593 @default.
• W2891852313 hasRelatedWork W2048186057 @default.
• W2891852313 hasRelatedWork W2143489661 @default.
• W2891852313 hasRelatedWork W2164855536 @default.
• W2891852313 hasRelatedWork W2369744902 @default.
• W2891852313 hasRelatedWork W2571299013 @default.
• W2891852313 hasRelatedWork W3016573916 @default.
• W2891852313 hasRelatedWork W3206555169 @default.
• W2891852313 isParatext "false" @default.
• W2891852313 isRetracted "false" @default.
• W2891852313 magId "2891852313" @default.
• W2891852313 workType "article" @default.