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- W2891853502 abstract "Significance The Michaelis–Menten (MM) formula arose to explain simple enzyme behavior. It has since been found to describe input–output responses in several other biological contexts. Its ubiquity has been surprising and poorly understood. Here, we use the graph-based “linear framework” to show how the MM formula arises whenever appropriate structural conditions are satisfied, both at thermodynamic equilibrium and when energy is being dissipated. These conditions are based on separating the graph into two parts and constraining how and where the input variable appears. The conditions do not depend on parameter values and allow many of the details to be arbitrary. This explains the ubiquity of the MM formula and substantially generalizes previous results." @default.
- W2891853502 created "2018-09-27" @default.
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- W2891853502 date "2018-09-07" @default.
- W2891853502 modified "2023-10-10" @default.
- W2891853502 title "Structural conditions on complex networks for the Michaelis–Menten input–output response" @default.
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- W2891853502 doi "https://doi.org/10.1073/pnas.1808053115" @default.
- W2891853502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6166846" @default.
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