FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891854127> ?p ?o ?g. }

• W2891854127 endingPage "164" @default.
• W2891854127 startingPage "158" @default.
• W2891854127 abstract "BackgroundPatients with Down syndrome carry a third copy of the amyloid precursor protein gene, which is localized on chromosome 21. Consequently, these patients are prone to develop early-onset Alzheimer disease and cerebral amyloid angiopathy. Post-mortem studies suggest increased amyloid deposition to be already detectable in children with Down syndrome. The aim of our study was to evaluate if amyloid-related changes in pediatric Down syndrome patients can be detected in vivo using MRI biomarkers of cerebral microbleeds and cortical superficial siderosis.Materials and methodsThis retrospective study included 12 patients with Down syndrome (mean age = 5.0 years) and 12 age-matched control subjects (mean age = 4.8 years). Frequency and location of microbleeds and siderosis were assessed on blood-sensitive MRI sequences in a consensus reading by two radiologists applying a modified Microbleed Anatomical Rating Scale.ResultsDown syndrome patients showed a significantly higher mean microbleeds count and likelihood of siderosis than age-matched controls. Across groups, the highest microbleeds count was found in lobar regions (gray and white matter of frontal, parietal, temporal, and occipital lobes, and the insula), while fewer microbleeds were located in subcortical and infratentorial regions. The number of microbleeds increased over time in all three Down syndrome patients with a follow-up exam.ConclusionIn vivo MRI biomarkers can support the diagnosis of early-onset cerebral amyloid angiopathy, which might already be present in pediatric Down syndrome patients. This might contribute to clinical decision-making and potentially to the development of therapeutic and prophylactic approaches, as cerebral amyloid angiopathy increases the risk for intracranial hemorrhage and may be associated with increased risk of developing Alzheimer disease." @default.
• W2891854127 created "2018-09-27" @default.
• W2891854127 creator A5010995483 @default.
• W2891854127 creator A5017342460 @default.
• W2891854127 creator A5027548979 @default.
• W2891854127 creator A5027583465 @default.
• W2891854127 creator A5035514608 @default.
• W2891854127 creator A5046912840 @default.
• W2891854127 date "2019-01-01" @default.
• W2891854127 modified "2023-10-16" @default.
• W2891854127 title "Increased cerebral microbleeds and cortical superficial siderosis in pediatric patients with Down syndrome" @default.
• W2891854127 cites W1578363248 @default.
• W2891854127 cites W1586465707 @default.
• W2891854127 cites W1776172174 @default.
• W2891854127 cites W1985323612 @default.
• W2891854127 cites W1994573232 @default.
• W2891854127 cites W1997279602 @default.
• W2891854127 cites W1998801224 @default.
• W2891854127 cites W2003160901 @default.
• W2891854127 cites W2005257697 @default.
• W2891854127 cites W2014667778 @default.
• W2891854127 cites W2017302232 @default.
• W2891854127 cites W2020567257 @default.
• W2891854127 cites W2025313184 @default.
• W2891854127 cites W2029485104 @default.
• W2891854127 cites W2032673644 @default.
• W2891854127 cites W2035828045 @default.
• W2891854127 cites W2041091896 @default.
• W2891854127 cites W2044385806 @default.
• W2891854127 cites W2048143236 @default.
• W2891854127 cites W2056745213 @default.
• W2891854127 cites W2068808615 @default.
• W2891854127 cites W2079178395 @default.
• W2891854127 cites W2081084853 @default.
• W2891854127 cites W2092675951 @default.
• W2891854127 cites W2103473142 @default.
• W2891854127 cites W2117854054 @default.
• W2891854127 cites W2124832732 @default.
• W2891854127 cites W2125469441 @default.
• W2891854127 cites W2130583999 @default.
• W2891854127 cites W2135148614 @default.
• W2891854127 cites W2140732046 @default.
• W2891854127 cites W2141771189 @default.
• W2891854127 cites W2144913309 @default.
• W2891854127 cites W2145396188 @default.
• W2891854127 cites W2147029696 @default.
• W2891854127 cites W2148954037 @default.
• W2891854127 cites W2149133024 @default.
• W2891854127 cites W2155894782 @default.
• W2891854127 cites W2162129433 @default.
• W2891854127 cites W2178701489 @default.
• W2891854127 cites W2233639407 @default.
• W2891854127 cites W2305950413 @default.
• W2891854127 cites W2399749275 @default.
• W2891854127 cites W2524663621 @default.
• W2891854127 doi "https://doi.org/10.1016/j.ejpn.2018.09.004" @default.
• W2891854127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30279085" @default.
• W2891854127 hasPublicationYear "2019" @default.
• W2891854127 type Work @default.
• W2891854127 sameAs 2891854127 @default.
• W2891854127 citedByCount "6" @default.
• W2891854127 countsByYear W28918541272019 @default.
• W2891854127 countsByYear W28918541272020 @default.
• W2891854127 countsByYear W28918541272021 @default.
• W2891854127 crossrefType "journal-article" @default.
• W2891854127 hasAuthorship W2891854127A5010995483 @default.
• W2891854127 hasAuthorship W2891854127A5017342460 @default.
• W2891854127 hasAuthorship W2891854127A5027548979 @default.
• W2891854127 hasAuthorship W2891854127A5027583465 @default.
• W2891854127 hasAuthorship W2891854127A5035514608 @default.
• W2891854127 hasAuthorship W2891854127A5046912840 @default.
• W2891854127 hasConcept C118552586 @default.
• W2891854127 hasConcept C126322002 @default.
• W2891854127 hasConcept C126838900 @default.
• W2891854127 hasConcept C142724271 @default.
• W2891854127 hasConcept C143409427 @default.
• W2891854127 hasConcept C2777790613 @default.
• W2891854127 hasConcept C2779134260 @default.
• W2891854127 hasConcept C2779483572 @default.
• W2891854127 hasConcept C2779954681 @default.
• W2891854127 hasConcept C2780860705 @default.
• W2891854127 hasConcept C2780883591 @default.
• W2891854127 hasConcept C71924100 @default.
• W2891854127 hasConceptScore W2891854127C118552586 @default.
• W2891854127 hasConceptScore W2891854127C126322002 @default.
• W2891854127 hasConceptScore W2891854127C126838900 @default.
• W2891854127 hasConceptScore W2891854127C142724271 @default.
• W2891854127 hasConceptScore W2891854127C143409427 @default.
• W2891854127 hasConceptScore W2891854127C2777790613 @default.
• W2891854127 hasConceptScore W2891854127C2779134260 @default.
• W2891854127 hasConceptScore W2891854127C2779483572 @default.
• W2891854127 hasConceptScore W2891854127C2779954681 @default.
• W2891854127 hasConceptScore W2891854127C2780860705 @default.
• W2891854127 hasConceptScore W2891854127C2780883591 @default.
• W2891854127 hasConceptScore W2891854127C71924100 @default.
• W2891854127 hasIssue "1" @default.
• W2891854127 hasLocation W28918541271 @default.
• W2891854127 hasLocation W28918541272 @default.

• next