Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891855204> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2891855204 abstract "ITCH (aka Atrophin-1-interacting protein 4) is a prominent member of the NEDD4 HECT (Homologous to E6AP C-Terminus) E3 ubiquitin ligase family that regulates numerous cellular functions including inflammatory responses through T-cell activation, cell differentiation, and apoptosis. Known intracellular targets of ITCH-dependent ubiquitylation include receptor proteins, signaling molecules, and transcription factors. The HECT C-terminal lobe of ITCH contains the conserved catalytic cysteine required for the covalent attachment of ubiquitin onto a substrate and polyubiquitin chain assembly. We report here the complete experimentally determined 1H, 13C, and 15N backbone and sidechain resonance assignments for the HECT C-terminal lobe of ITCH (residues 784–903) using heteronuclear, multidimensional NMR spectroscopy. These resonance assignments will be used in future NMR-based studies to examine the role of dynamics and conformational flexibility in HECT-dependent ubiquitylation as well as deciphering the structural and biochemical basis for polyubiquitin chain synthesis and specificity by ITCH." @default.
- W2891855204 created "2018-09-27" @default.
- W2891855204 creator A5031071553 @default.
- W2891855204 creator A5053693636 @default.
- W2891855204 creator A5071060262 @default.
- W2891855204 date "2018-09-18" @default.
- W2891855204 modified "2023-10-07" @default.
- W2891855204 title "1H, 13C, and 15N resonance assignments of the C-terminal lobe of the human HECT E3 ubiquitin ligase ITCH" @default.
- W2891855204 cites W1826484537 @default.
- W2891855204 cites W1993775542 @default.
- W2891855204 cites W2027988262 @default.
- W2891855204 cites W2030531891 @default.
- W2891855204 cites W2032030313 @default.
- W2891855204 cites W2049110428 @default.
- W2891855204 cites W2082176639 @default.
- W2891855204 cites W2083665788 @default.
- W2891855204 cites W2104148692 @default.
- W2891855204 cites W2117754842 @default.
- W2891855204 cites W2120772351 @default.
- W2891855204 cites W2129243549 @default.
- W2891855204 cites W2144362290 @default.
- W2891855204 cites W2169821755 @default.
- W2891855204 cites W2290268596 @default.
- W2891855204 cites W2315101365 @default.
- W2891855204 cites W2485590864 @default.
- W2891855204 cites W2763477705 @default.
- W2891855204 doi "https://doi.org/10.1007/s12104-018-9843-2" @default.
- W2891855204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6439258" @default.
- W2891855204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30229450" @default.
- W2891855204 hasPublicationYear "2018" @default.
- W2891855204 type Work @default.
- W2891855204 sameAs 2891855204 @default.
- W2891855204 citedByCount "1" @default.
- W2891855204 countsByYear W28918552042020 @default.
- W2891855204 crossrefType "journal-article" @default.
- W2891855204 hasAuthorship W2891855204A5031071553 @default.
- W2891855204 hasAuthorship W2891855204A5053693636 @default.
- W2891855204 hasAuthorship W2891855204A5071060262 @default.
- W2891855204 hasBestOaLocation W28918552041 @default.
- W2891855204 hasConcept C104317684 @default.
- W2891855204 hasConcept C12554922 @default.
- W2891855204 hasConcept C134459356 @default.
- W2891855204 hasConcept C185592680 @default.
- W2891855204 hasConcept C25602115 @default.
- W2891855204 hasConcept C2777265272 @default.
- W2891855204 hasConcept C55493867 @default.
- W2891855204 hasConcept C71240020 @default.
- W2891855204 hasConcept C86803240 @default.
- W2891855204 hasConcept C95444343 @default.
- W2891855204 hasConceptScore W2891855204C104317684 @default.
- W2891855204 hasConceptScore W2891855204C12554922 @default.
- W2891855204 hasConceptScore W2891855204C134459356 @default.
- W2891855204 hasConceptScore W2891855204C185592680 @default.
- W2891855204 hasConceptScore W2891855204C25602115 @default.
- W2891855204 hasConceptScore W2891855204C2777265272 @default.
- W2891855204 hasConceptScore W2891855204C55493867 @default.
- W2891855204 hasConceptScore W2891855204C71240020 @default.
- W2891855204 hasConceptScore W2891855204C86803240 @default.
- W2891855204 hasConceptScore W2891855204C95444343 @default.
- W2891855204 hasFunder F4320337354 @default.
- W2891855204 hasLocation W28918552041 @default.
- W2891855204 hasLocation W28918552042 @default.
- W2891855204 hasLocation W28918552043 @default.
- W2891855204 hasOpenAccess W2891855204 @default.
- W2891855204 hasPrimaryLocation W28918552041 @default.
- W2891855204 hasRelatedWork W1986108347 @default.
- W2891855204 hasRelatedWork W1999857522 @default.
- W2891855204 hasRelatedWork W2033084145 @default.
- W2891855204 hasRelatedWork W2047749760 @default.
- W2891855204 hasRelatedWork W2078835223 @default.
- W2891855204 hasRelatedWork W2080443900 @default.
- W2891855204 hasRelatedWork W2097800224 @default.
- W2891855204 hasRelatedWork W2140267101 @default.
- W2891855204 hasRelatedWork W2148325247 @default.
- W2891855204 hasRelatedWork W2272989235 @default.
- W2891855204 isParatext "false" @default.
- W2891855204 isRetracted "false" @default.
- W2891855204 magId "2891855204" @default.
- W2891855204 workType "article" @default.