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- W2891856444 abstract "Introduction: The Mediator complex regulates gene transcription by linking the basal transcriptional machinery with DNA bound transcription factors. The activity of the Mediator complex is modulated by a kinase submodule comprised of 4 proteins, including MED12. Although ubiquitously expressed, studies suggest that these proteins differentially regulate gene expression in a tissue-specific manner. MED12 regulates development in a variety of cell types through the regulation of different gene programs. Consequently, MED12 null mice are embryonically lethal, however the function of MED12 in the heart is not yet known. Hypothesis: We tested the hypothesis that MED12 is required for normal cardiac function. Methods: Mice harboring conditional cardiac-specific deletion of MED12 (cKO) were generated. We performed serial echocardiography on male cKO mice and controls through 12 weeks of age. RNAseq was performed on P1 ventricles, and calcium transients were measured using fluo-4 AM in P1 cardiomyocytes (CM). Chr..." @default.
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- W2891856444 date "2016-11-11" @default.
- W2891856444 modified "2023-09-23" @default.
- W2891856444 title "Abstract 19553: Med12 is a Transcriptional “Mediator” of Cardiac Contractile Function" @default.
- W2891856444 hasPublicationYear "2016" @default.
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